Composite medicine coating balloon, preparation method thereof, and composite medicine coating balloon dilatation catheter

A drug coating and balloon technology, which is applied to balloon catheters, catheters, coatings, etc., can solve the problems of poor drug release, easy detachment of drug coatings, and inability to achieve therapeutic effects, so as to improve bioavailability. effect of reducing blood flow scour loss and reducing drug loss

Active Publication Date: 2020-06-23
KOSSEL MEDTECH SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By increasing the drug loading of the balloon coating, the drug absorption can be increased locally, but a large amount of excess drugs flow to the distal end of the blood vessel, affecting the health of patients
Due to the short expansion time of ordinary drug balloon dilation catheters, the drug is not released well, so the current problems and difficulties faced by ordinary drug balloon dilation catheters are as follows: 1. While the drug coating is released quickly, the delivery process will also be affected by blood Wash away a lot of drugs; 2. The drug adheres to the wall for a short time, and it is difficult to be absorbed by the blood vessel wall in large quantities, so that a good therapeutic effect cannot be achieved; 3. The drug coating is easy to fall off and produce particles, which is easy to produce thrombus

Method used

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  • Composite medicine coating balloon, preparation method thereof, and composite medicine coating balloon dilatation catheter
  • Composite medicine coating balloon, preparation method thereof, and composite medicine coating balloon dilatation catheter
  • Composite medicine coating balloon, preparation method thereof, and composite medicine coating balloon dilatation catheter

Examples

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preparation example Construction

[0068] The preparation method of the drug spray solution B comprises step (i) or step (ii):

[0069] (i) dissolving the drug B and the coating agent in a solvent to obtain a drug solution B; then ultrasonically spraying the drug solution B, after drying, collecting the drug particles wrapped by the coating agent, and then dispersing them in an aqueous solution or an aqueous solution containing an emulsifier , to obtain drug particle suspension solution; filter to remove drug particles with large particle size, and then mix them into a solution containing excipients to obtain drug spray solution B;

[0070] (ii) Dissolving the drug B and the encapsulating agent in a solvent to obtain a drug solution B; adding the drug solution B dropwise to an aqueous solution containing an emulsifier, and after molding treatment, a suspension solution of drug particles wrapped by the encapsulating agent is obtained ; Filter and remove large-diameter drug particles, and then mix them into a solut...

Embodiment 1

[0080] Take by weighing 50mg paclitaxel and 50mg PDLGA and be dissolved in the mixed solvent (volume ratio 1:3) of 10ml acetone and dichloromethane, after fully dissolving, this solution is joined in 1wt% polyvinyl alcohol aqueous solution, ultrasonic emulsification 60min, high-speed stirring ( 1500rpm) after 60min of the emulsion, use a filter membrane with a pore size of 2um to filter to obtain the drug suspoemulsion.

Embodiment 2

[0082] Weigh 120mg of rapamycin and 100mg of lecithin and dissolve them in 20ml of methanol. After fully dissolving, add this solution to 100ml of 2wt% polysorbate aqueous solution, use a high-speed homogenizer to disperse and emulsify at a speed of 15,000rpm, and take 5min. The emulsion was stirred for 5 hours at a rotation speed of 1000 rpm, then the emulsion was centrifuged at a rotation speed of 2000 rpm, and the supernatant was taken to obtain a drug particle suspension.

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Abstract

The invention discloses a composite medicine coating balloon. The composite medicine coating balloon comprises a balloon body and a composite medicine coating covering the surface of the balloon body,wherein the composite medicine coating comprises a bottom-layer coating, a middle-layer coating and an outer-layer coating; the bottom-layer coating is used for coating the surface of the balloon body, and consists of medicines A and a hydrophilic excipient; the middle-layer coating consists of a medicine B packed with a packing agent and hydrophilic excipients / lipophilic excipients / amphipathic excipients; and the outer-layer coating consists of a medicine C and lipophilic excipients / amphipathic excipients. The invention further discloses a preparation method of the composite medicine coatingballoon and a composite medicine coating balloon dilatation catheter. According to the composite medicine coating balloon, the loss of traditional Chinese medicines in the balloon transporting process can be reduced, besides, the vasculopathy position can have effective medicine concentration within a short term, vascular restenosis is restrained, long-time medicine release can be provided, durable medicine action time can be maintained, and the restenosis rate can be reduced.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a composite drug-coated balloon, a preparation method of the composite drug-coated balloon, and a balloon dilation catheter comprising the composite drug-coated balloon. Background technique [0002] In recent years, with the rapid development of neuroimaging, catheter technology, materials, and computers, endovascular interventional technology has become increasingly mature in the treatment of vascular diseases, and has been affirmed by doctors and patients for its minimally invasive, safe, and effective features. At present, it has become one of the important treatment methods for vascular diseases. [0003] Balloon angioplasty is an established method of treating vascular disease by physically dilating areas of atherosclerosis, reduced lumen diameter, or narrowing in diseased vessels. Typically, angioplasty is performed using a catheter that is advanced within the cir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/10A61L29/08A61L29/14A61L29/16
CPCA61L29/08A61L29/14A61L29/146A61L29/16A61L2300/416A61L2300/602A61L2300/606A61M25/10A61M25/1029A61M2025/1031A61M2025/105A61M2025/1079A61M2207/00
Inventor 胡清黄俭汪令生王志高
Owner KOSSEL MEDTECH SUZHOU
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