Dry suspension containing cefixime liposome and preparation method thereof
A technology of cefixime and dry suspension, which is applied in the field of medicine, can solve the problems of poor solubility, stability and bioavailability, and achieve the effects of improving bioavailability, sufficient drug effect, and less toxic and side effects
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[0070] Example 1: Preparation of Cefixime Liposome
[0071] Name of raw materials
[0072] Preparation:
[0073] (A) Dissolve hydrogenated soy lecithin, hydrogenated egg yolk lecithin, cholesterol, and polysorbate 80 in an appropriate amount of absolute ethanol according to the prescribed amount, and mix well to obtain solution I; the amount of absolute ethanol used is the amount of cefixime 30 times;
[0074] (B) Weigh the prescribed amount of cefixime, add an appropriate amount of phosphate buffer with a pH of 7.0 to completely dissolve it to obtain a cefixime solution;
[0075] (C) Weigh povidone K according to the prescription amount 30 , Add the above phosphate buffer to dissolve and prepare povidone K with a concentration of 0.78mg / ml 30 Solution; Then add the above-mentioned cefixime solution and mix well to obtain solution II;
[0076] (D) Using a pipette pump, inject solution I into solution II, and stir continuously at a high speed to completely hydrate the phospholipid me...
Example Embodiment
[0081] Example 2: Preparation of Cefixime Liposome
[0082] Name of raw materials
[0083] Preparation:
[0084] (A) Dissolve hydrogenated soy lecithin, hydrogenated egg yolk lecithin, cholesterol, and polysorbate 80 in an appropriate amount of absolute ethanol according to the prescribed amount, and mix well to obtain solution I; the amount of absolute ethanol used is the amount of cefixime 25 times;
[0085] (B) Weigh the prescribed amount of cefixime, add an appropriate amount of phosphate buffer with a pH of 7.5 to completely dissolve it to obtain a cefixime solution;
[0086] (C) Weigh povidone K according to the prescription amount 30 , Add the above-mentioned phosphate buffer to dissolve and prepare povidone K with a concentration of 0.66mg / ml 30 Solution; Then add the above-mentioned cefixime solution and mix well to obtain solution II;
[0087] (D) Using a pipette pump, inject solution I into solution II, and stir continuously at a high speed to completely hydrate the phosp...
Example Embodiment
[0092] Example 3: Preparation of Cefixime Liposome
[0093] Name of raw materials
[0094] cholesterol
[0095] Preparation:
[0096] (A) Dissolve hydrogenated soy lecithin, hydrogenated egg yolk lecithin, cholesterol, and polysorbate 80 in an appropriate amount of absolute ethanol according to the prescribed amount, and mix well to obtain solution I; the amount of absolute ethanol used is the amount of cefixime 30 times;
[0097] (B) Weigh the prescribed amount of cefixime, add an appropriate amount of phosphate buffer with a pH of 7.9 to completely dissolve it to obtain a cefixime solution;
[0098] (C) Weigh povidone K according to the prescription amount 30 , Add the above-mentioned phosphate buffer to dissolve and prepare povidone K with a concentration of 0.80mg / ml 30 Solution; Then add the above-mentioned cefixime solution and mix well to obtain solution II;
[0099] (D) Using a pipette pump, inject solution I into solution II, and stir continuously at a high speed to comp...
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