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Dry suspension containing cefixime liposome and preparation method thereof

A technology of cefixime and dry suspension, which is applied in the field of medicine, can solve the problems of poor solubility, stability and bioavailability, and achieve the effects of improving bioavailability, sufficient drug effect, and less toxic and side effects

Inactive Publication Date: 2011-02-16
王丽燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Chinese patents CN101606913A and CN101401810A disclose cefixime dispersible tablets and their preparation methods. The dispersible tablets are all made from cefixime raw materials without any modification. The solubility, stability and biological Utilization is poor

Method used

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  • Dry suspension containing cefixime liposome and preparation method thereof
  • Dry suspension containing cefixime liposome and preparation method thereof
  • Dry suspension containing cefixime liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1: the preparation of cefixime liposome

[0071] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

215.00

430.00

860.00

Hydrogenated egg yolk lecithin

215.00

430.00

860.00

cholesterol

430.00

860.00

1720.00

Polysorbate 80

80.00

160.00

320.00

total

990.00

1980.00

3960.00

[0072] Preparation:

[0073] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 30 times;

[0074] (B) take by weighing the cefixime of recipe quantity, add the phosphate buffer saline solution that an appropriate pH value is 7.0 and make it dissolve completely, obtain cefixime solution;

[0075...

Embodiment 2

[0081] Embodiment 2: the preparation of cefixime liposome

[0082] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

165.00

330.00

660.00

Hydrogenated egg yolk lecithin

165.00

330.00

660.00

cholesterol

330.00

660.00

1320.00

Polysorbate 80

60.00

120.00

240.00

total

770.00

1540.00

3080.00

[0083] Preparation:

[0084] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 25 times;

[0085] (B) taking by weighing the cefixime of recipe quantity, add the phosphate buffer saline solution that the appropriate pH value is 7.5 and make it dissolve completely, obtain cefixime solution;

[0...

Embodiment 3

[0092] Embodiment 3: the preparation of cefixime liposome

[0093] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

125.00

250.00

500.00

Hydrogenated egg yolk lecithin

125.00

250.00

500.00

[0094] cholesterol

250.00

500.00

1000.00

Polysorbate 80

45.00

90.00

180.00

total

595.00

1190.00

2380.00

[0095] Preparation:

[0096] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 30 times;

[0097] (B) take by weighing the cefixime of recipe quantity, add the phosphate buffer saline solution that an appropriate pH value is 7.9 and make it dissolve completely, obtain cefixime ...

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PUM

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Abstract

The invention relates to cefixime liposome and preparation method therefore as well as dry suspension containing the cefixime liposome. The dry suspension is composed of the cefixime liposome and pharmaceutically acceptable carriers, wherein the cefixime liposome comprises the following components in parts by weight: 1 part of cefixime, 1.25-5 parts of hydrogenated soybean lecithin, 1.25-5 parts of hydrogenated yolk lecithin, 2.5-10 parts of cholesterol and 0.1-5 parts of polysorbate 80. The dry suspension not only accords with the requirements of Chinese pharmacopoeia, but also has the advantages of better storage stability in normal temperature, faster effect exertion and obviously improved bioavailability in comparison with the common cefixime medicaments.

Description

technical field [0001] The invention relates to a cefixime liposome, a preparation method thereof and a dry suspension containing it. The cefixime dry suspension is more stable than common cefixime pharmaceutical compositions when stored at room temperature, The invention has the advantages of faster drug effect and significantly improved bioavailability, belonging to the field of medical technology. Background technique [0002] Acute pelvic inflammatory disease refers to the acute inflammation of female pelvic reproductive organs and its surrounding connective tissue and pelvic peritoneum, including metritis, salpingo-oophoritis, pelvic connective tissue inflammation and pelvic peritonitis, which can occur in one or several places at the same time. One of the common diseases. The development of acute pelvic inflammatory disease can cause diffuse peritonitis, sepsis, septic shock, and severe cases can be life-threatening. Lower abdominal pain accompanied by fever at the t...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/34A61P15/00A61P31/00A61K31/546A61K9/16A61K47/26
Inventor 王丽燕
Owner 王丽燕
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