Duloxetine enteric coated tiny pill capsule, and preparation method

A technology of duloxetine intestines and loxetine intestines, which is applied in the direction of bulk delivery, nervous system diseases, active ingredients of heterocyclic compounds, etc., and can solve problems that do not involve solid dispersion technology

Active Publication Date: 2006-04-19
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this patent, the inventor also did not relate to the solid dispersion technology used in this patent

Method used

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  • Duloxetine enteric coated tiny pill capsule, and preparation method
  • Duloxetine enteric coated tiny pill capsule, and preparation method
  • Duloxetine enteric coated tiny pill capsule, and preparation method

Examples

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Embodiment 10

[0104] The recipe process of Example 10 is similar to that of Example 9. Raise the temperature of the material in the fluidized bed to 60°C in the finished layer, slowly wrap the molten beeswax on the pellets, and sprinkle the micropowdered silica gel on the pellets after cooling. On the pill, pack into 3# capsules to obtain duloxetine enteric-coated micropill capsules. Dissolution profile see Figure 4 .

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Abstract

An enteric micropill (microsoftgel) of Duluoxiting and its preparing process are disclosed. Said micropill is composed of an empty core pill and a coated external layer consisting of a principal medicine layer, an isolating layer and an enteric layer. It features that its principal medicine can be quickly released only in small intestine.

Description

technical field [0001] The invention relates to an oral preparation of duloxetine and its salts, in particular to a duloxetine enteric-coated pellet capsule and a preparation method thereof. Background technique [0002] Depression is one of the leading causes of loss of work and life. As fatigue progresses, patients lose the ability to make decisions, function normally, or perform basic self-care activities. The acceleration of the pace of modern life and the increase of social pressure have brought great challenges to people's psychological endurance. According to the latest medical literature, about 12% of people suffer from depression, but the effective rate of antidepressants currently available clinically is less than 70%, and the onset time is generally more than 15 days, and some are difficult to tolerate Many patients lose confidence in treatment due to side effects (sexual dysfunction, severe gastrointestinal reactions). [0003] Duloxetine, chemically named (+)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/38A61K9/16A61P25/24
Inventor 金方闻聪
Owner SHANGHAI INST OF PHARMA IND CO LTD
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