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Enteric soluble coating slow releasing tablet containing huperzine A and preparing method

A technology of huperzine A and enteric coating, which is applied in the field of medicine, can solve the problems of forgetting and missing doses, delaying the timing of treatment, unfavorable treatment, etc., and achieves the effects of convenient medication, complete release and prolonged curative effect

Inactive Publication Date: 2005-10-19
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients with memory impairment and AD have difficulties in taking medicine on time. If the medical staff or family members do not remind them, they will easily forget to take or miss the dose, which will delay the timing of treatment, which is not good for treatment

Method used

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  • Enteric soluble coating slow releasing tablet containing huperzine A and preparing method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Tablet core prescription composition (50 tablets):

[0019] Component name Weight Percentage

[0020] Huperzine A 5mg -

[0021] hypromellose

[0022] 60%

[0023] K15M 3.6g

[0024] Compressible starch 2.2g 36%

[0025] Lactose 0.2g 3%

[0026] Magnesium stearate 0.06g 1%

[0027] 80% ethanol appropriate amount

[0028] Theoretical tablet weight: 120mg / tablet

[0029] 2. Core preparation process:

[0030] (1) Take each auxiliary material (except magnesium stearate) by prescription quantity, mix well; Stand-by;

[0031] (2) Dissolve huperzine A with 80% ethanol solution, prepare a solution of 1 mg / ml, accurately measure huperzine A solution (equivalent to the prescription amount) and add it to the mixed auxiliary materials to make soft materials;

[0032](3) cross 24 mesh sieves to make wet granules;

[0033]...

Embodiment 2

[0045] 1. Tablet core prescription composition (50 tablets):

[0046] Component name Weight Percentage

[0047] Huperzine A 10mg -

[0048] hypromellose

[0049] 60%

[0050] K100M 3.6g

[0051] Compressible starch 2.2g 36%

[0052] Lactose 0.2g 3%

[0053] Magnesium stearate 0.06g 1%

[0054] 80% ethanol appropriate amount

[0055] Theoretical tablet weight: 120mg / tablet

[0056] 2. Core preparation process:

[0057] (1) Take each auxiliary material (except magnesium stearate) by prescription quantity, mix well; Stand-by;

[0058] (2) Dissolve huperzine A with 80% ethanol solution, prepare a 1mg / ml solution, and accurately measure the huperzine

[0059] Pinetaxine A solution (equivalent to the prescription amount) is added to the mixed auxiliary materials to make soft materials;

[0060] (3) cross...

Embodiment 3

[0073] 1. Tablet core prescription composition (50 tablets):

[0074] Component name Weight Percentage

[0075] Huperzine A hydrochloride 5mg -

[0076] hypromellose

[0077] 40%

[0078] K4M 2.4g

[0079] hypromellose

[0080] 40%

[0081] K15M 1.2g

[0082] Microcrystalline Cellulose 2.2g 36%

[0083] Lactose 0.2g 3%

[0084] Magnesium stearate 0.06g 1%

[0085] 80% ethanol appropriate amount

[0086] Theoretical tablet weight: 120mg / tablet

[0087] 2. Core preparation process:

[0088] (1) Take each auxiliary material (except magnesium stearate) by prescription quantity, mix well; Stand-by;

[0089] (2) Dissolve huperzine A with 80% ethanol solution, prepare a solution of 1 mg / ml, accurately measure huperzine A solut...

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Abstract

The present invention discloses a kind of slow releasing enteric soluble coated tablet containing hyperzine A and its preparation process. Enteric soluble coating technology is adopted to overcome the bad effect of lower pH in stomach on the diffusion of medicine in skeleton tablet to ensure the stable, slow and complete release of medicine. The slow releasing tablet contains hyperzine A as reversible anticholinesterase and has one layer of enteric soluble polymer film coating outside the skeleton slow releasing layer. The active medicine component may be also various pharmaceutically acceptable acid salts of hyperzine A. Each tablet contains hyperzine A I n10-500 microgram and has sustained release time of 20 hr.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically, it is an enteric-coated sustained-release tablet containing huperzine A and a preparation method thereof Background technique: [0002] Huperzine A, the chemical name is (6R,5R,11E)-5-amino-11-ethyl-6,6,9,1 0-tetrahydro-7-methyl-6,9-methylenecyclotetra Ekeno[b]pyridin-2(1H)-one is a new structural alkaloid extracted from Huperzia serrata (Thμnb.) Tre v. by Chinese medical researchers. Pharmacological research The results show that huperzine A is a potent, reversible cholinesterase inhibitor, which has a strong inhibitory effect on true cholinesterase (AChE) (Yang Chunyu "Chinese Medicinal Materials", 1988, 11 (1): 40). It easily enters the brain tissue, inhibits AChE at cholinergic synapses, and corrects central cholinergic insufficiency. The efficacy of huperzine A in the treatment of middle-aged and elderly memory loss and Alzheimer's syndrome (AD) has been clinically verifie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/28A61K31/435A61P25/00A61P25/28
Inventor 丁平田白敏
Owner SHENYANG PHARMA UNIVERSITY
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