Compound chlorhexidine acetate microemulsion disinfectant and its preparation method

A technology of chlorhexidine acetate and disinfectant, which is applied in the direction of disinfectant, botany equipment and method, biocide, etc., can solve the problems of low water solubility and the preparation cannot be used after being diluted, and achieves simple preparation method and prolonged disinfection Action time, effect of improving stability

Inactive Publication Date: 2013-05-08
HENAN INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The unilateral or compound chlorhexidine acetate dosage forms that have been developed at present mainly contain suppositories, sprays, solutions, lotions, film-coating agents, etc., but the ubiquitous deficiencies of these dosage forms are exactly: because chlorhexidine acetate itself has low water solubility The disadvantage is that the content of chlorhexidine acetate in the preparation can only meet the clinical needs, and the preparation cannot be diluted for use
Therefore, low water solubility has become a key factor limiting the development and application of chlorhexidine acetate formulations

Method used

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  • Compound chlorhexidine acetate microemulsion disinfectant and its preparation method
  • Compound chlorhexidine acetate microemulsion disinfectant and its preparation method
  • Compound chlorhexidine acetate microemulsion disinfectant and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Weigh 11.0 g of chlorhexidine acetate, 11.0 g of benzalkonium bromide, 18.5 g of polyoxyethylene ether hydrogenated castor oil (RH40), 12.5 g of ethanol, 3.4 g of ethyl acetate and 43.6 g of distilled water, and set aside;

[0029] (2) Mix the prescribed amount of chlorhexidine acetate and ethanol, then mix with RH40, then add ethyl acetate and mix, set aside;

[0030] (3) Dissolve the prescribed amount of benzalkonium bromide in distilled water as the water phase for later use;

[0031] (4) At room temperature, slowly add the above water phase to the system while stirring continuously until a clear and transparent liquid is formed, that is, the compound chlorhexidine acetate microemulsion disinfection with a particle size of 10-100 nm and a clear and uniform appearance is prepared. agent.

Embodiment 2

[0033] (1) Weigh 0.02 g of chlorhexidine acetate, 0.02 g of benzalkonium bromide, 25 g of polyoxyethylene ether hydrogenated castor oil (RH40), 8.3 g of propylene glycol, 2.7 g of ethyl acetate and 64.0 g of distilled water, and set aside;

[0034] (2) Mix the prescribed amount of chlorhexidine acetate and propylene glycol, then mix with polyoxyethylene ether hydrogenated castor oil (RH40), then add ethyl acetate and mix, and set aside;

[0035] (3) Dissolve the prescribed amount of benzalkonium bromide in distilled water as the water phase for later use;

[0036] (4) At room temperature, slowly add the above water phase to the system while stirring continuously until a clear and transparent liquid is formed, that is, the compound chlorhexidine acetate microemulsion disinfection with a particle size of 10-100 nm and a clear and uniform appearance is prepared. agent.

Embodiment 3

[0038] (1) Weigh 6 g of chlorhexidine acetate, 3.6 g of benzalkonium bromide, 30.2 g of polyoxyethylene ether hydrogenated castor oil (RH40), 18.6 g of isopropanol, 5.0 g of ethyl acetate and 36.6 g of distilled water, and set aside ;

[0039] (2) Mix the prescribed amount of chlorhexidine acetate and isopropanol, then mix with polyoxyethylene ether hydrogenated castor oil (RH40), then add ethyl acetate and mix, set aside;

[0040] (3) Dissolve the prescribed amount of benzalkonium bromide in distilled water as the water phase for later use;

[0041] (4) At room temperature, slowly add the above water phase to the system while stirring continuously until a clear and transparent liquid is formed, that is, the compound chlorhexidine acetate microemulsion disinfection with a particle size of 10-100 nm and a clear and uniform appearance is prepared. agent.

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Abstract

The invention relates to a disinfectant, and aims to provide a compound chlorhexidine acetate microemulsion disinfectant having the advantages of good water solubility, strong disinfection effect, long disinfection effect maintenance time and good stability, and its preparation method. The compound chlorhexidine acetate microemulsion disinfectant is prepared through using the following raw materials, by weight, 0.02-11.0 parts of chlorhexidine acetate, 0-11.0 parts of benzalkonium bromide, 18.5-30.2 parts of a surfactant, 0-18.6 parts of a cosurfactant, 2.7-5.0 parts of oil and 36.6-67.2 parts of distilled water. The compound chlorhexidine acetate microemulsion disinfectant has the advantages of high chlorhexidine acetate content, use convenience, simple production technology, low production cost, and convenience for the scale production.

Description

[0001] Technical field: [0002] The invention relates to the technical field of disinfectants, in particular to a compound chlorhexidine acetate microemulsion disinfectant and a preparation method thereof. Background technique: [0003] Chlorhexidine acetate, also known as chlorhexidine, belongs to biguanide cationic surfactants. Because of its broad antibacterial spectrum, it has strong antibacterial and bactericidal effects on Gram-positive bacteria and negative bacteria, local irritation and allergic reactions. Smaller and other advantages, it is widely used in clinical practice, mainly used for disinfection of skin, mucous membranes, wounds, instruments, etc. [0004] Chlorhexidine acetate is a low-efficiency disinfectant, and it is one of the active ingredients of many disinfectants and health care compound preparations. In order to improve its disinfection efficacy in clinical application, it is often prepared into various compound preparations for use. The unilate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A01N33/12A01N25/04A01N25/30A01P1/00A61K31/155A61K31/14A61K9/107A61K47/44A61P31/04
Inventor 杨雪峰任秀娟刘保国柳东阳张慧辉王自良胡建和齐永华徐彦召孙亚伟
Owner HENAN INST OF SCI & TECH
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