68results about How to "Rounded surface" patented technology

The invention provides a CD-MOF composite microsphere and a preparation method thereof. Specifically, the CD-MOF composite microsphere contains a drug-loaded CD-MOF component (a) of a cubic crystal structure and a component (b) wrapping the component (a). The composite microsphere provided by the invention can overcome the problem that CD-MOF used as a drug storage cavern disintegrates in the presence of water, protects the intactness of a CD-MOF porous skeleton structure, prevents burst release of drugs and realizes slow release of drugs.

The invention discloses a medicine granule containing the following components by mass percent: 75 to 95 of medicine, 2 to 22 of thinner for pelletization, 0.06t to 0.5 of glidant, and 1.5 to 3.5 of adhesive. The invention also discloses a preparation method thereof and a preparation containing same. The medicine granule has high medicine content, round surface, higher rigidity and smaller grain diameter, can be directly used for tabletting, has less weight increment if being coated and can achieve a better taste masking effect. The method for preparing the medicine granule can simultaneously realize pelletization and coating technologies in a tangent spraying fluidized bed, has simple production steps and high efficiency, and can be applied to mass production.

The invention discloses a preparation method of vanadium oxide and lithium iron phosphate composite materials with a high tap density. The method comprises the following steps: (1) preparing a lithium iron phosphate precursor; (2) preparing the vanadium oxide and lithium iron phosphate composite materials; and (3) molding processing, sintering under a temperature of 500-800 DEG C in an atmosphere of nitrogen, crushing the sintered materials, and sieving by a sieve of 100-400 meshes to obtain the vanadium oxide and lithium iron phosphate composite materials with the high tap density. The method can greatly improve diffusion capacity of lithium ion among particles, and thus improve power performance of the lithium iron phosphate. Spherical-like precursors are compacted and sintered after a drying processing of a secondary mixing, and thus pores among particle are reduced, components of the precursors are combined tightly, and the reaction is carried out adequately. The sintered lithium iron phosphate particles are round in surface morphology, and can effectively improve tap density of the materials.

An object of the present invention is to provide a method for manufacturing electrodes that can effectively suppress edge-curl when metal electrodes such as bus electrodes and data electrodes are patterned mainly by a photolithography method.In order to achieve the above object, in the manufacturing method in the present invention, an amount of undercut generated by difference in a degree of dissolution caused by developing solution is controlled, and baking is performed at a temperature such that glass in a protrusion formed at side edges becomes soft so as to touch a substrate by gravity. With such method for manufacturing, it becomes possible to make the side edges rounded whose curvature changes continuously.

The invention belongs to the technical field of phosphorus copper balls for electroplating and particularly relates to a production method of an oversized-diameter anode phosphorus copper ball. The method comprises the following steps of: firstly melting pure copper and phosphorus copper intermediate alloy to obtain a phosphorus copper alloy solution and producing a phosphorus copper alloy rod by utilizing the uniformly mixed phosphorus copper alloy solution through an upward casting method; feeding the obtained phosphorus copper alloy rod into a continuous extruding machine for extrusion, wherein the phosphorus copper alloy rod is driven by an extrusion wheel to be forcedly pressed into an extrusion cavity and is extruded according to the designed size so as to obtain an ultra-fine grain phosphorus copper rod blank; and finally performing cold heading and molding on the obtained ultra-fine grain phosphorus copper rod blank by utilizing a cold header, so as to form phosphorus copper ball of design specification. The phosphorus copper ball obtained by utilizing the production method has a smooth, round and complete surface and a compact internal crystal structure, and has the advantage of obviously improved appearance and internal quality compared with the phosphorus copper ball obtained by utilizing an existing technology.

The invention discloses a microsphere preparation encapsulating a hydrophilic medicine, and the microsphere preparation comprises the following components in percentage by weight: a hydrophilic medicine 0.1-40%, methoxy poly(ethylene glycol)-poly(lactic acid) block copolymers 0.1-99%, and poly(lactic acid) or poly(lactic acid-glycollic acid) copolymers 0.1-99%. The microsphere preparation has round and intact surface, uniform and controllable particle diameter, high encapsulation rate, and controllable drug release behaviors. The invention also discloses a preparation method of the microsphere preparation encapsulating the hydrophilic medicine, and the preparation method has simple process and good controllability and comprises the following steps: adding a water solution of the hydrophilic medicine into an organic solution of the methoxy poly(ethylene glycol)-poly(lactic acid) block copolymers, and vortexing to form water-in-oil type primary emulsion; adding the primary emulsion intoliquid paraffin containing emulsifier I, and vortexing to form water-in-oil type multiple emulsion; and adding the multiple emulsion into liquid paraffin containing emulsifier II, continuing stirringfor 4-24 h, centrifuging, collecting pellets, washing, and drying to obtain the microsphere preparation encapsulating the hydrophilic medicine.

An object of the present invention is to provide a method for manufacturing electrodes that can effectively suppress edge-curl when metal electrodes such as bus electrodes and data electrodes are patterned mainly by a photolithography method. In order to achieve the above object, in the manufacturing method in the present invention, an amount of undercut generated by difference in a degree of dissolution caused by developing solution is controlled, and baking is performed at a temperature such that glass in a protrusion formed at side edges becomes soft so as to touch a substrate by gravity. With such method for manufacturing, it becomes possible to make the side edges rounded whose curvature changes continuously.

The invention discloses a preparation method of a special solid polishing agent for a stainless steel product, and belongs to the technical field of metal processing aids. The method comprises the following steps that the coated modified aluminum oxide and absolute ethyl alcohol are mixed firstly and then undergo ultrasonic dispersion, then the treatment is carried out by using polyvinylpyrrolidone, the coated modified aluminum oxide dispersion liquid is prepared, then the coated modified aluminum oxide dispersion liquid and the monomer acrylamide are mixed, under the action of a cross-linkingagent and an initiator, the monomer is polymerized to form the three-dimensional size network gel, then the dopamine is used for assistant, after the reaction is finished, vacuum drying is carried out, the dry gel is prepared, then the dry stearic acid, the linoleic acid, the citric acid and the oxalic acid are mixed, then heating and melting are carried out, then the dry gel is added, after stirring and mixing are achieved, injection molding, cooling and forming, and demolding are carried out, and the special solid polishing agent for the stainless steel product is obtained. According to thepreparation method, the prepared special solid polishing agent for the stainless steel product has an excellent polishing effect, and the glossiness is effectively improved.

The invention discloses a preparation method of cerium dioxide fluoride polishing powder under a microwave condition, which belongs to the technical field of nano rare earth material preparation. Thepreparation method comprises the following steps: dissolving Ce(NO3)3.6H2O in deionized water, preheating in a microwave mode, and adding NH4F; dissolving NH4HCO3 in deionized water, adding a preheated Ce(NO3)3.6H2O and NH4F mixed solution into the deionized water, carrying out a constant-temperature precipitation reaction under a microwave condition to generate a Ce2(CO3)3 precursor, and continuing to age the Ce2(CO3)3 precursor; filtering the precursor reaction solution to obtain a precipitate, drying at a constant temperature, and grinding into powder; and roasting the precursor powder to prepare cerium dioxide fluoride polishing powder. The cerium dioxide powder prepared by the method disclosed by the invention is high in particle crystallinity, regular and spherical in morphology, uniform in particle size distribution and good in dispersity, and the polishing efficiency and the polishing precision of the fluorinated cerium dioxide powder are further improved.

The present invention relates to a spherical or spherical-like cathode material for lithium-ion battery and a lithium-ion battery. The chemical formula of the cathode material is LiaNixCoyMnzMbO2, wherein: 1.02≤a≤1.20; 0.0≤b≤0.5; 0.30≤x≤0.60; 0.20≤y≤0.40; 0.05≤z≤0.50; x+y+z=1; M is one or two or more selected from the group consisting of Mg Ti Al Zr Y Co Mn Ni Ba and rare earth elements. Under the scanning electron microscope, the cathode material comprises primary particles with a morphology of spherical or spherical shape, and secondary particles agglomerated by the primary particles. The number percentage of the secondary particles agglomerated by the primary particles is less than or equal to 30%. The lithium battery prepared by the obtained cathode material has high specific capacity, high temperature stability, excellent safety and cycling performance at high temperature, and the preparation method thereof is simple and the cost is relatively low.

The invention relates to a preparation method of clostridium butyricum embedded chitosan nanoparticles in the technical field of feed additives. The preparation method comprises the following steps: preparing a chitosan stock solution; adding an isopyknic clostridium butyricum bacteria liquid into the chitosan stock solution, uniformly mixing by a magnetic stirring method to prepare a clostridium butyricum mixed liquor; and dropwisely adding a sodium tripolyphosphate aqueous solution into the clostridium butyricum mixed liquor, carrying out magnetic stirring at room temperature so as to prepare the clostridium butyricum embedded chitosan nanoparticles. The preparation method is simple to operate. The clostridium butyricum embedded chitosan nanoparticles can be obtained by simple mixing of chitosan / clostridium butyricum / sodium tripolyphosphate. The particles have advantages of no adhesion, good spheronization and round surface. Under an acid or alkali condition consistent with acid-base value of pig stomach and intestine, clostridium butyricum can be rapidly released, thus helping better perform efficacy of clostridium butyricum for feed.

The invention relates to a steel-structure high lamp column foot protection device and a manufacturing method thereof, and belongs to the technical field of building engineering and safety protection. According to the steel-structure high lamp column foot protection device and the manufacturing method thereof, the structure is simple, use is convenient, a column foot can be effectively protected, the anticorrosion effect is good, and the protection effect is good. According to the technical scheme, the column foot can be subject to anticorrosion treatment, the portion within the range of a column foot bolt, a stiffened plate and the like is filled with expansion vermiculite concrete, preformed holes with dehumidifying and positioning functions are reserved, a waterproof mortar protection layer is smeared, and the protection device is formed; and the protection device is of a structure with the upper portion smaller than the lower portion, and weather-resisting sealing glue exists in the joint portion of the protection device and a lamp column. The column foot protection device is fragile in core and hard in shell and is easy to open and convenient to maintain and use. The protection device is widely applied to protection of steel-structure column feet of high lamp columns in public places like a stadium.

The invention discloses a circularly-used tundish castable for an industrial furnace and a preparation technology thereof. The circularly-used tundish castable for the industrial furnace comprises the following components by weight percentage: 70-85% of a scrap steel package castable, 10-25% of special-grade alumina, 1-6% of mullite, 2-3% of silica powder, 2-3% of cement, and 0.1-0.15% of an additive. The circularly-used tundish castable for the industrial furnace is capable of saving mineral resources, reducing the environmental pollution, greatly reducing the cost of a fireproof material, and reducing the environmental pollution of parts of industrial wastes. The environment is protected, the secondary utilization of the energy and resource can be realized, and the circularly-used tundish castable for the industrial furnace has the remarkable effects of energy conservation and environmental protection.

The invention provides a method for adjusting enriched nutrients in monoammonium phosphate through utilizing phosphate flotation tailings. The method includes the following steps: taking phosphate flotation tailings as raw materials, and adding phosphate flotation tailings subjected to concentration and treated by a filter to diluted phosphoric acid for mixed reaction; introducing ammonia gas for neutralizing and then adding nitrogenous fertilizer, uniformly mixing for nitrogen increment, so as to obtain qualified monoammonium phosphate slurry; performing concentration, spraying granulation, drying, sieving, cooling, wrapping and package to the slurry to obtain the monoammonium phosphate product. According to the invention, an effective technological approach is provided for the comprehensive utilization of phosphate flotation tailings, the method has important practical significances in saving phosphate rock resources, improving the pelleting performance of monoammonium phosphate slurry, increasing the nutritional value of the monoammonium phosphate product, adjusting the enriched nutrients of the monoammonium phosphate product, reducing discharge and stockpiling of phosphate flotation tailings and promoting the sustainable development of the phosphate and compound fertilizer industry; besides, raw materials are wide in source and low in cost, and new waste residues and waste water cannot be generated.

The invention discloses a method for printing patterns on a ceramic knife by lasers, which relates to the processing technology of the ceramic knife, in particular to a technological method for printing the patterns on the ceramic knife. The method comprises the following steps of (1) coating a layer of organic coatings on a to-be-processed workpiece, wherein the organic coatings are epoxy resin water-based paint or polyurethane; and (2) adopting a metal laser printer, forming a high-energy light beam by lasers emitted by a CO2 laser after the lasers are focused, projecting the high-energy light beam to the organic coating layer of the to-be-processed workpiece, enabling the organic coatings which are projected to be quickly gasified, and presenting needed patterns. According to the method disclosed by the invention, the problems that patterns and words are generally baked on an existing ceramic knife, the technology is complicated, the cost is high, and pattern lines are unclear are solved.

The invention discloses a method for preparing microsphere preparation coated with hydrophilic medicaments. The method has simple process and good controllability, and comprises: adding hydrophilic medicament water solution into an organic solution containing a polylactic acid-polyethylene glycol monomethyl ether segmented copolymer, and carrying out vortex to form water-in-oil initial emulsion; adding the initial emulsion into liquid paraffin containing an emulsifying agent I, and carrying out the vortex to form water-in-oil compound emulsion; and adding the compound emulsion into petroleum ether containing an emulsifying agent II, continuing stirring for 10 minutes-60 minutes, collecting microspheres through centrifugation, washing and drying to obtain the microsphere preparation coated with the hydrophilic medicaments.

The invention discloses butt welding abrasive equipment for machining a windowsill protective steel frame. The equipment comprises a sleeve loading frame, a swing mounting plate, an abrasive table anda butt welding mechanism, wherein the grinding table is located above the sleeve loading frame, the butt welding mechanism is arranged in the middle of the upper portion of the grinding table, one side of the sleeve loading frame is vertically provided with two side stand columns, and the upper end and the lower end of the two side stand columns are each provided with a motor I. The butt weldingabrasive equipment has the beneficial effects that components on the steel frame are welded by a welding gun, the adjustment and moving scope of the welding gun on the equipment is larger, and the welding gun is adjusted and moved up and down through a hydraulic cylinder II, so that it is guaranteed that the device can weld the steel frames with different volumes and heights, and meanwhile the precision of components for butt welding and machining on the equipment on the steel frame is greatly improved by the welding gun on the equipment; and two welding seats arranged in parallel synchronously work on different areas on the steel frame, so that the butt welding efficiency of the equipment on the steel frame is greatly improved.

The invention discloses a preparation method for hypericin albumin nanometer particles, which comprises (1) using bovine serum albumin as a carrier material to be dissolved in distilled water to manufacture carrier solution with the mass concentration of 10% to 40%; (2) dissolving hypericin in ethanol with the concentration more than 95% to produce oil phase with the mass concentration of 20% to 40%; (3) adding the oil phase having been fully stirred into the carrier solution, adjusting potential of hydrogen (PH) to 9, dropwise adding emulsifier to fully emulsify, then dropping glutaraldehyde to cure for more than 24 hours, and obtaining curing nanometer particle solution; (4) centrifuging at high speed of 15,000 rpm / min to 20,000 rpm / min, removing supernate, adding distilled water to perform ultrasonic dispersion, centrifuging again at high speed, removing supernate, washing with water and collecting, and drying in vacuum or freezing mode to achieve hypericin albumin nanometer particles. The hypericin albumin nanometer particles prepared with the method are good in stability on light and heat, and effective content of hypericin is improved.

The invention discloses abscisic acid-embedded chitosan nanoparticles and a preparation method thereof. The abscisic acid-embedded chitosan nanoparticles are nanoparticles formed by wrapping aqueous solution of abscisic acid by an embedding material which is formed by dilute solution of acetic acid of chitosan and a crosslinking agent. The preparation method comprises the following steps of: adding the chitosan into the dilute solution of acetic acid to be dissolved, and then adding solution of sodium hydroxide to adjust the pH value to obtain dilute solution of acetic acid of the chitosan; preparing abscisic acid into aqueous solution; preparing the crosslinking agent into aqueous solution; adding the solution of dilute acetic acid of the chitosan into the aqueous solution of abscisic acid, and then adding the aqueous solution of crosslinking agent drop by drop; and fully mixing uniformly to obtain the abscisic acid-embedded chitosan nanoparticles. The method is simple and easy, and has high embedding rate; the obtained embedding nanoparticles have no adhesion, good glomeration and round surface; after the embedding, the abscisic acid can be protected from external interference, and the stability of the abscisic acid can be improved; the abscisic acid is steadily and slowly released, which prolongs action time and strengthens induced resistance effect; and the chitosan serving as a wall material has disease-resistant and induced resistance effects.

The invention discloses spherical titanium powder and a preparation method thereof. According to the preparation method of the spherical titanium powder, sponge titanium is taken as a raw material, the sponge titanium is subjected to hydrogenation, crushing and dehydrogenation to prepare the hydrogenated dehydrogenated titanium powder, and then ethanol is added to carry out wet-process ball milling to prepare the spherical titanium powder. The adopted raw material, namely, the sponge titanium is low in cost and wide in source, so that the production cost is reduced; the production process is simple, the production period is short, and the required equipment is simple; the spherical titanium powder prepared by the method is round in surface, high in spherical degree, uniform in particle size, good in mobility, excellent in performance, suitable for 3D printing forming, and good in forming performance, and the mechanical property of a formed material is outstanding.

The invention provides crabapple granulated tea and a preparation method and application thereof, and belongs to the technical field of substitutional tea products. The crabapple leaves and the substitutional tea are uniformly mixed according to a certain proportion, and a framework material aqueous solution is used as an adhesive to prepare the granulated tea. The product has the advantages of smooth surface, roundness and uniform size, clear and transparent soup color, high tea water extract content, bitter taste first and sweet aftertaste, stable release of particle contents, brewing resistance, small size, exquisite package, convenience in carrying and drinking and the like; and meanwhile, the preparation process is scientific, rigorous and extremely suitable for large-scale industrialproduction, so that the beverage has good practical popularization and application value.

The invention discloses a method for rare earth treatment of Al2O3 inclusions in a full process of cast rolling of refined ultra-low-carbon IF steel. At the tail stage of RH refining procedure treatment, rare earth Ce is added, the content of Ce in molten steel reaches 15 ppm, after rare earth alloy is added, re-pressing is carried out for 5 min, after re-pressing, soft blowing is carried out above 8 min, and the average sizes of the Al2O3 inclusions in the thickness directions of a casting blank can be reduced. At the tail stage of RH refining procedure treatment, rare earth Ce is added, thecontent of Ce in the molten steel reaches 15 ppm, Ce is combined with activity O in steel, the lower gibbs free energy is achieved, the concentration and the degree of supersaturation of aluminum andoxygen can be reduced, the capacity of forming the large-size clustered inclusions formed by gathering of single-particle Al2O3 can be reduced, the concentration and the degree of supersaturation of aluminum and oxygen can be reduced, and the capacity of forming the large-size clustered inclusions by the single-particle Al2O3 gathering can be reduced.

The invention discloses a new energy automobile intelligent monitoring liquid cooling high-power charging cable and a production technology, and the cable comprises a main cable core which is formed by twisting a power wire core, a control wire core, a grounding wire core, an auxiliary wire core, a composite cooling pipe and an optical fiber unit, and a main cable core wrapping tape and a sheath which sequentially wrap the main cable core. A gap of the main cable core is filled with cable core filler, cooling pipes are arranged in the power wire core, the control wire core and the auxiliary wire cores respectively, the power wire core is tangent to the control wire core and the grounding wire core respectively, the auxiliary wire cores are arranged on the two sides of the control wire core, and the composite cooling pipe is arranged in the gap between the power wire core and the grounding wire core. And the optical fiber unit is arranged in a gap between the power wire core and the control wire core. The temperature of the cable in the charging process is monitored at any time through the optical fiber unit, use safety is ensured, the temperature of the power wire core and the control wire core is reduced through the cooling pipe, the current-carrying capacity is more than three times that of a common charging pile cable, charging efficiency is high, heat dissipation performance is good, and the service life of the cable is prolonged.

The invention relates to the field of ore, in particular to an ore waste treatment device. The technical aim to be achieved by the invention is to provide the ore waste treatment device. The ore wastetreatment device comprises a bottom-layer working frame plate, a first supporting high leg column, a grinding and crushing mechanism, a secondary intercepting and fragmentation mechanism, a separation disc grinding mechanism, an operation control screen, an integration strip frame and the like. One side of the upper part of the bottom-layer working frame plate is sequentially connected with the first supporting high leg column and a second supporting high leg column. By means of the device, the effects that waste leftover materials left after granite cutting is completed are efficiently crushed, meanwhile, secondary fragmentation after interception is conducted on large stones leaked through primary crushing, long-strip-shaped stones with the qualified width are separated, stones with edges obtained through crushing are subjected to double-face disc grinding, the edges are ground and removed, and smooth granite stones are obtained for the paving are achieved.

The invention discloses an abelmoschus manihot-filbert chewable tablet and a preparation method thereof and belongs to the field of health care products. The abelmoschus manihot-filbert chewable tablet is prepared by taking abelmoschus manihot and filberts as principal raw materials and taking inulin, a corrigent and magnesium stearate as auxiliary materials, wherein the mass ratio of inulin to abelmoschus manihot to filberts is (0.8-1.1):1:(0.5-1.5). Compared with the prior art, the abelmoschus manihot-filbert chewable tablet has the advantages of filbert fragrance and special faint scent of abelmoschus manihot, smooth and round surface, yellow green color and the characteristics of being tasty and refreshing, fine and smooth, sour and sweet and tasty; the chewable tablet is rich in nutrition and is rich in flavone, microelements, unsaturated fatty acid and fructo-oligose required by a human body; the preparation method of the chewable tablet is simple; the raw materials are easily acquired; and the chewable tablet is fit for industrial production.

The invention discloses a risperidone-loaded PLGA microsphere mixture and a preparation method thereof. With adopting of an improved double-emulsion-solvent evaporation method, that is, on the basis of the double-emulsion method, an inner core is a sustained-release gel formed by chelation of sodium alginate and calcium ions, PLGA is used as a microsphere carrier, risperidone is a wrapping object,and the drug-loaded microspheres are prepared. The shape is round, the particle size distribution is uniform, the average particle size distribution is about 30 microns, the drug loading amount is 30% or more, the encapsulation efficiency is about 50%, and the drug release in vitro conforms to the characteristics of long-acting preparations.

The invention relates to a super-hydrophobic coating and a preparation method and application thereof. The super-hydrophobic coating is an oily coating containing antifouling microspheres; the antifouling microspheres comprise silica aerogel powder and an adhesive. The preparation method of the super-hydrophobic coating comprises the following steps: firstly, uniformly mixing the antifouling microspheres and the alumina aerogel with a mixed solvent in the coating, then uniformly mixing with the acrylic resin, the epoxy resin and the rosin in the coating, and finally uniformly mixing with other components in the coating to prepare the super-hydrophobic coating. The coating is used for the ship bottom to form the super-hydrophobic surface so that various marine organisms cannot be attached to the ship bottom, and the antifouling effect is effectively achieved.

The invention relates to a processing method of a platinum-rhodium alloy wire with high rhodium content, and belongs to the technical field of metal materials. After vacuum melting, hot forging into strips, rolling into long and round shape, and high temperature drawing, the platinum-rhodium alloy wire between phi 0.1mm and phi 3.0mm is finally obtained. The platinum-rhodium alloy wire material prepared by the invention is smooth and round in surface, has no defects such as white spots, knots, and chaps, can be used in the fields of heating components, temperature measurement and the like, andis good in using effect. The platinum-rhodium alloy wire with high rhodium content is prepared by adopting the vacuum melting and high temperature drawing process, and compared with traditional coldprocessing, the processing method of the platinum-rhodium alloy wire with the high rhodium content provided by the invention has the advantages of being short in processing cycle, low in precious metal loss, stable in product quality and the like.

The invention relates to the field of biomedicines, and particularly relates to an insulin sustained-release oral patch as well as a preparation method and an application thereof. The pharmaceutical preparation is characterized by comprising nanoparticles and pharmaceutical excipients that comprise a filler, an adhesive and a lubricant. The dosage form of the pharmaceutical preparation is an oral patch. According to the invention, insulin is prepared into the sustained-release oral patch, thereby avoiding first-pass effect of gastrointestinal tracts, prolong action time of the medicine, improving curative effect and economic benefit of the medicine, reducing influence of enzymes on the insulin, and relieving pain of patients due to injection. The oral patch of the present invention is high in adhesive capacity, good in release and moderate in dissolution rate.

The invention discloses a method for preparing self-assembled medicine-carried microspheres by combining a high-voltage electrostatic liquid droplet method and a layer-by-layer self-assembly method. In the invention, growth factor-containing sodium alginate aqueous solution is used as raw material solution; calcium chloride solution is used as a gel bath; microcapsules are prepared in a high-voltage electrostatic field; growth factor is uniformly distributed in microgel; and then a plurality of high molecular polyelectrolyte membranes are assembled on the surface of the microgel by using an electrostatic nano layer-by-layer self-assembly technology to obtain the self-assembled medicine-carried microspheres. The self-assembled medicine-carried microspheres prepared by the method have smooth and round surfaces and high uniformity; the activity of the growth factor can be protected; burst release can be effectively avoided; and long-acting constant-speed release is realized.