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Cyclodextrin-metal organic framework (CD-MOF) composite microsphere and preparation method thereof

A metal-organic framework and composite microsphere technology, applied in non-active ingredients medical preparations, microcapsules, pharmaceutical formulations, etc., can solve the problems of drug burst release, structural collapse, easy collapse of CD-MOF, etc., to achieve good protection effect of action

Active Publication Date: 2018-03-27
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biocompatibility of the materials used is poor, such as polymethylmethacrylate, polyimide, polyvinyl acetate, polysulfone, polydimethylsiloxane, polyvinylpyrrolidone and styrene, etc.
At the same time, CD-MOF has the problems of easy collapse and structural disintegration when exposed to water, and it is easy to cause sudden release of drugs when used as a drug carrier.

Method used

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  • Cyclodextrin-metal organic framework (CD-MOF) composite microsphere and preparation method thereof
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  • Cyclodextrin-metal organic framework (CD-MOF) composite microsphere and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0232] (c) The preparation method of the present invention can maintain the structural integrity of CD-MOF.

[0233] (d) The preparation method of the present invention has simple and controllable process, low cost and good effect.

Embodiment 1

[0239] The prescription is shown in the table below:

[0240]

[0241] The preparation process is as follows:

[0242] Weigh 50 mg of ibuprofen-loaded CD-MOF and disperse it in 3 mL of acetone, ultrasonically disperse it evenly, weigh 450 mg of polyacrylic acid resin (MOF: polyacrylic acid resin ratio 1:9, w / w) and dissolve it, then add 120 mg Aluminum stearate (dispersant) is dispersed evenly by ultrasonication for 5 minutes, which is the dispersed phase. Add the dispersed phase containing aluminum stearate to liquid paraffin (ice-bathed to 10°C), place the above suspension in an ice-water bath at 10°C, stir magnetically (500rpm, 30s), and disperse with a disperser (10000rpm, 5min) to obtain an S / O / O type emulsion. Place the above-mentioned emulsion on a magnetic stirrer, and under the condition of 500rpm stirring, slowly raise the temperature from 10°C to 35°C (the setting of magnetic stirring heating is 65, and the heating rate is 10°C·min-1), and then continue to stir...

Embodiment 2

[0245] The prescription is shown in the table below:

[0246]

[0247] The preparation process is as follows:

[0248] Weigh 50 mg of lansoprazole-loaded CD-MOF and disperse it in 3 mL of acetone, ultrasonically disperse it evenly, weigh 450 mg of polyacrylic acid resin (MOF: polyacrylic acid resin is 1:9, w / w) and dissolve in it, then add 120mg of aluminum stearate (dispersant) was ultrasonically dispersed for 5 minutes to form a dispersed phase. Add the dispersed phase containing aluminum stearate to liquid paraffin (ice-bathed to 10°C), place the above suspension in an ice-water bath at 10°C, stir magnetically (500rpm, 30s), and disperse with a disperser (10000rpm, 5min) to obtain an S / O / O type emulsion. Place the above-mentioned emulsion on a magnetic stirrer, and under the condition of 500rpm stirring, slowly raise the temperature from 10°C to 35°C (the setting of magnetic stirring heating is 65, and the heating rate is 10°C·min-1), and then continue to stir for 3h (...

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PUM

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Abstract

The invention provides a CD-MOF composite microsphere and a preparation method thereof. Specifically, the CD-MOF composite microsphere contains a drug-loaded CD-MOF component (a) of a cubic crystal structure and a component (b) wrapping the component (a). The composite microsphere provided by the invention can overcome the problem that CD-MOF used as a drug storage cavern disintegrates in the presence of water, protects the intactness of a CD-MOF porous skeleton structure, prevents burst release of drugs and realizes slow release of drugs.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a cyclodextrin-metal organic framework material composite microsphere and a preparation method thereof. Background technique [0002] Cyclodextrin-metal-organic framework mainly uses cyclodextrin to form a new crystal in an organic coordination manner with the first and second main group metal ions in aqueous solution. This crystal has porous, large surface area, Features such as storage gas. This green, porous material can adsorb some structurally unstable drugs, and its huge cavity can protect the drug, which makes its commercial development possible, especially because the cyclodextrin-metal-organic Edible derivative, suitable for human consumption. Using cyclodextrin as an organic ligand and metal ions as an inorganic metal center, a new, safer and pharmaceutically acceptable cyclodextrin-metal organic framework, namely CD-MOF, can be formed. [0003] Similar to existing MOFs, ...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K9/50A61K47/32C08J3/14
CPCA61K9/5026C08J3/14C08J2405/16C08J2333/00
Inventor 张继稳李海燕吕娜娜伍丽刘波涛李雪
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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