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Antineoplastic compound deacetylase fungus epoxy ethyl ester injection and preparation method thereof

A technology of ethylene oxide injection and ethylene oxide, which is applied in the field of compounds, can solve the problem of insoluble ethylene oxide of deacetylated fungi, reduce the volume of administration and toxic and side effects, have high drug solubility, and be easy to transport Effect

Active Publication Date: 2011-01-26
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of anti-tumor compound deacetylated fungal ring that can solve the insoluble problem of deacetylated fungal oxirane, can improve the oral bioavailability of deacetylated fungal ethylene oxide, and has better stability. Oxyethyl lipid injection and preparation method thereof

Method used

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  • Antineoplastic compound deacetylase fungus epoxy ethyl ester injection and preparation method thereof
  • Antineoplastic compound deacetylase fungus epoxy ethyl ester injection and preparation method thereof
  • Antineoplastic compound deacetylase fungus epoxy ethyl ester injection and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] Example 1: Weigh 1 g of deacetylated fungal oxirane, 1880.5 g of poloxamer, 0.5 g of lecithin, and 0.3 g of hydroxypropyl methylcellulose, put them in a 200 ml beaker, measure 100 ml of distilled water, and add them to the beaker , high-speed shearing machine 15000rpm pre-dispersion 2min. Use a high-pressure homogenizer to homogenize 3 times at pressures of 500 bar and 1000 bar respectively, and then homogenize 5 times at a pressure of 1200 bar. Weigh 3g of mannitol, add it to the above solution, stir to dissolve, divide into vials, 2ml per bottle, freeze in -80°C ultra-low temperature refrigerator for 24 hours, take it out and put it into a freeze-dried product whose temperature has dropped to -50°C Put it on the shelf of the machine, cover it with a vacuum cover, turn on the switch of the vacuum pump, and freeze-dry for 48 hours. After the freeze-drying is finished, take out the pressurized aluminum cap and pack it for storage, and then obtain the anti-tumor compound...

Embodiment 2

[0024] Example 2: Weigh 1 g of acetylated fungal oxirane, 1 g of lecithin, and 0.3 g of hydroxypropyl methylcellulose, place them in a 200 ml beaker, measure 100 ml of distilled water, add them to the beaker, and pre-disperse with a high-speed shearing machine at 15000 rpm 2min. Use a high-pressure homogenizer to homogenize 3 times at pressures of 500 bar and 1000 bar respectively, and then homogenize 5 times at a pressure of 1200 bar. Weigh 3g of lactose, add it to the above solution, stir to dissolve, divide into vials, 2ml per bottle, freeze in -80°C ultra-low temperature refrigerator for 24 hours, take it out and put it into a freeze dryer whose temperature has dropped to -50°C On the shelf, cover with a vacuum cover, turn on the vacuum pump switch, and freeze-dry for 48 hours. After the freeze-drying is finished, take out the pressurized aluminum cap and pack it for storage, and then obtain the anti-tumor compound deacetylated fungus ethylene oxide injection.

Embodiment 3

[0025] Embodiment 3: Weigh 1 g of ethylene oxide ester of deacetylated fungi, 1881 g of poloxamer, and 300.3 g of povidone K, and place them in a 200 ml beaker, measure 100 ml of distilled water, add them to the beaker, and pre-disperse with a high-speed shearing machine at 15000 rpm 2min. Use a high-pressure homogenizer to homogenize 3 times at pressures of 500 bar and 1000 bar respectively, and then homogenize 5 times at a pressure of 1200 bar. Weigh 3g of mannitol, add it to the above solution, stir to dissolve, divide into vials, 2ml per bottle, freeze in -80°C ultra-low temperature refrigerator for 24 hours, take it out and put it into a freeze-dried product whose temperature has dropped to -50°C Put it on the shelf of the machine, cover it with a vacuum cover, turn on the switch of the vacuum pump, and freeze-dry for 48 hours. After the freeze-drying is finished, take out the pressurized aluminum cap and pack it for storage, and then obtain the anti-tumor compound deace...

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Abstract

The invention provides an antineoplastic compound deacetylase fungus epoxy ethyl ester injection and a preparation method thereof, belonging to a compound. The antineoplastic compound deacetylase fungus epoxy ethyl ester injection can solve the slightly solubility problem of deacetylase fungus epoxy ethyl ester, can increase the oral bioavailability of deacetylase fungus epoxy ethyl ester and hasgood stability. The antineoplastic compound deacetylase fungus epoxy ethyl ester injection is nano suspension freeze-dried powder and comprises deacetylase fungus epoxy ethyl ester, a surface active agent, a suspending agent and a freeze-drying protecting agent in the mass ratio of 1:(0.5-10):(0-10):(2-10). The preparation method comprises the following steps of: putting deacetylase fungus epoxy ethyl ester, the surface active agent and the suspending agent in a container, adding water, predispersing, homogenizing, adding the freeze-drying protecting agent, dissolving by stirring, subpackaging, freezing, and freeze-drying to obtain the antineoplastic compound deacetylase fungus epoxy ethyl ester injection.

Description

technical field [0001] The invention relates to a compound, in particular to an anti-tumor compound deacetylated fungi ethylene oxide injection and a preparation method thereof. Background technique [0002] my country has a population of 1.3 billion, and so far there are still many diseases that seriously threaten people's lives and health and lack effective prevention and treatment drugs, especially tumors. The pain and economic losses caused by this are immeasurable. It is an urgent need in the field of population and health in my country to continuously research and create new and excellent drugs for these important diseases. [0003] The applicant provided an anti-tumor compound deacetylated fungus ethyl oxide ester and a preparation method thereof in Chinese patent CN1903858, the fungus being Phomosis sp. A-1-2-3, the The strain has been preserved by the applicant in the China Center for Typical Culture Collection, and the registered preservation number is CCTCC NO: M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/366A61K47/24A61K47/32A61K47/34A61K47/36A61K47/38A61P35/00A61K47/10A61K47/26
Inventor 黄耀坚郑忠辉宋思扬苏文金沈月毛
Owner XIAMEN UNIV
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