Clathrate of mesoporous silicon oxide/Fe3O4 magnetic nano-grade complex and ibuprofen
A technology of mesoporous silica and magnetic nanometers, which can be used in drug combinations, organic active ingredients, non-central analgesics, etc., can solve the problem of decreased sensitivity of pain receptors, achieve high drug content, high solubility, increase Conspicuous effect
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[0013] Example 1
[0014] Fe 3 O 4 Preparation
[0015] 2.7gFeCl 3 Dissolve 7.2g sodium acetate in 100ml ethylene glycol solution, mix evenly, stir well and transfer to the crystallization kettle, crystallize at 200℃ for 6h, wash 3 times with absolute ethanol, separate, dry at 60℃ for 6h, save for later use.
Example Embodiment
[0016] Example 2
[0017] Mesoporous silica coated Fe 3 O 4
[0018] 1.0g Fe 3 O 4 Disperse uniformly in a mixture of water and ethanol (volume ratio 80:60), add 3g cetyltrimethylammonium bromide template, 10ml ammonia (28wt%), stir and mix well, add 4g positive Tetraethyl silicate, stirred for 8 hours, washed 3 times with absolute ethanol, separated, and dried at 60°C.
Example Embodiment
[0019] Example 3
[0020] Mesoporous silica / Fe 3 O 4 Inclusion compound of magnetic nanocomposite and ibuprofen
[0021] Mesoporous silica / Fe 3 O 4 30 mg of magnetic nanocomposite was added to the ethanol solution of ibuprofen (containing 15 mg of ibuprofen), the ultrasonic reaction was carried out for 5 hours, the product was washed with double distilled water, separated with a permanent magnet, and dried at 50°C for 8 hours to obtain mesoporous silica / Fe 3 O 4 The inclusion compound of magnetic nanocomposite and ibuprofen. The inclusion rate measured by ultraviolet-visible spectrophotometer was 51.10%, and the actual drug content of the inclusion compound was 7.39 mg / g.
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