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Method for preparing polymer magnetic drug-carrying particle using supercritical Co2 anti-dissolving agent process

A technology of drug-loaded particles and polymers, which is applied in the fields of chemical and biomedical engineering, can solve problems such as thrombus or blood vessel blockage, large particle size, and drug deterioration, and achieve high biological activity, low operating temperature, and no environmental pollution.

Inactive Publication Date: 2005-12-21
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the drug microspheres with natural polymers as carriers need to be cross-linked during the preparation process, the packaged drugs will deteriorate, and the particle size is large, which may cause thrombus or vascular obstruction when injected into the living body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1- Embodiment 3

[0025] serial number

Embodiment 4

[0027] Add 0.1 g of the magnetic powder modified by the silane coupling agent into the polylactic acid copolymer (PLGA) chloroform solution containing 0.1 g of fenofibrate and a certain concentration (wherein the mass of the polymer is 1 g, the drug and the polymer The weight ratio is 1 / 10), and put into the reactor after ultrasonic dispersion; then CO 2 Spray into the reactor at a rate of 2kg / h. After the system stabilizes for about 5 minutes, continuously feed fresh CO into the reactor. 2 And at the same time, a certain amount of CO is continuously discharged at the other outlet of the reactor 2 , keep the pressure at 20MPa and the temperature at 40°C through the backup valve device, and this process lasts for 90 minutes. After the end, CO 2 Wash the residual organic solvent in the reaction kettle at a rate of 0.5kg / h, and finally slowly reduce to normal pressure, and open the kettle to collect the product.

[0028] serial number

Embodiment 5

[0030] First, a certain amount of magnetic powder modified by sodium lauryl sulfate surfactant was added to polylactic acid-polyethylene glycol copolymer containing 0.1g anticancer drug norcantharidin and a solution concentration of 10mg / ml. (PLLA-PEG) in the dichloromethane solution (wherein the quality of polymer is 1g, and the weight ratio of drug and polymer is 1 / 10), puts into the reactor after being dispersed uniformly; Then CO 2 Spray into the reactor at a rate of 3kg / h. After the system stabilizes for about 5 minutes, continuously feed fresh CO into the reactor. 2 And at the same time, a certain amount of CO is continuously discharged at the other outlet of the reactor 2 , keep the pressure at about 15MPa and the temperature at 40°C through the backup valve device, and this process lasts for 90 minutes. After the end, CO 2 Wash the residual organic solvent in the reaction kettle at a rate of 0.5kg / h, and finally slowly reduce to normal pressure, and open the kettle ...

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Abstract

The method for preparing polymer magnetic medicine-loaded particle by utilizing the process using supercritical CO2 to resist solvent mainly includes the following steps: firstly, adding magnetic powder into polymer solution containing medicine, uniformly dispersing said magnetic powder, placing them into reaction still, then injecting CO2 into reaction still according to a certain flow rate, making the solute undergo the supercritical CO2 reversed-phase extraction process, be crystallized, precipitated and separated out, continuously introducing CO2 to clean residual organic solvent to obtain the polymer particle containing medicine and magnetic powder.

Description

technical field [0001] The invention belongs to the field of chemical and biomedical engineering, in particular to a method for preparing polymer magnetic particles, in particular to a method of using supercritical CO 2 A method for preparing polymer magnetic drug-loaded microparticles by anti-solvent technology. Background technique [0002] In view of the fact that in addition to killing normal cells, the traditional drug delivery method also has certain side effects and toxicity to other parts of the organism, so at present, higher requirements are put forward for the clinical application of drugs, and the medical field urgently needs to study and adopt the most effective methods. And the pathway allows the drug to enter the point of need in the body, that is, the target site, and makes the drug effect play a role in the minimum dose range to achieve a high-efficiency and low-toxicity therapeutic effect. For example, antitumor agents act directly on cancer cells without ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16
Inventor 任杰滕新荣张鹏
Owner TONGJI UNIV
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