Magnetic metal oxide microsphere in core-shell structure and its prepn process

A magnetic metal, core-shell structure technology, applied in the preparation method of peptides, ferrous oxides, chemical instruments and methods, etc., can solve the problems of complicated column packing, time-consuming and laborious operation, etc. Easy to obtain, controllable particle size effect

Inactive Publication Date: 2007-11-07
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of column packing is relatively complicated; using high-speed centrifugation, there are still two disadvantages: the operation is time-consuming and laborious; high-speed centrifugation may cause high-quality non-phosphorylated peptides and phosphorylated peptides to co-precipitate

Method used

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  • Magnetic metal oxide microsphere in core-shell structure and its prepn process

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Experimental program
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Effect test

Embodiment 1

[0023] Weigh 0.1g of ferric oxide microspheres with an average particle size of 300nm and disperse them in 1M hydrochloric acid aqueous solution, ultrasonically treat them for 5min, then use a magnet to separate and wash them for 3 times, and disperse the washed microspheres in 40mL of 20g / L glucose aqueous solution And in 180 ℃ hydrothermal reaction 6h. The product was separated with a magnet, and washed 4 times with deionized water, and the obtained magnetic carbon spheres Fe 3 o 4 @C was vacuum-dried for later use.

[0024] Weigh 0.5g of aluminum isopropoxide and dissolve it in 20mL of alcohol / water (volume ratio 4 / 1) solution and stir for 10min, add 0.2g of Fe obtained above 3 o 4 @C microspheres were ultrasonically oscillated for 2 min, and then the Fe adsorbed on the aluminum hydroxide oligomer was 3 o 4 The @C microspheres were separated, washed with ethanol three times, and finally calcined at 600°C in nitrogen for 1 hour to obtain microspheres with an inner core ...

Embodiment 2

[0026] Weigh 0.2g of iron ferric oxide microspheres with an average particle size of 200nm and disperse them in 0.5M hydrochloric acid aqueous solution, ultrasonically treat them for 8min, then use a magnet to separate and wash them for 5 times, and disperse the washed microspheres in 20mL of 20g / L glucose aqueous solution And in 180 ℃ hydrothermal reaction 10h. The product was separated with a magnet, and washed 3 times with deionized water, and the obtained magnetic carbon spheres Fe 3 o 4 @C was vacuum-dried for later use.

[0027] Weigh 0.7g zirconium isopropoxide and dissolve it in 20mL alcohol / water (volume ratio 4 / 1) solution and stir for 10min, add 0.1g Fe obtained above 3 o 4 @C microspheres were ultrasonically oscillated for 3 min, and then the Fe adsorbed zirconium hydroxide oligomers were 3 o 4 The @C microspheres were separated, washed with ethanol for 3 times, and finally calcined at 500°C for 2 hours in nitrogen to obtain microspheres with a core of ferric ...

Embodiment 3

[0029] Weigh 0.3g of iron ferric oxide microspheres with an average particle size of 600nm and disperse them in 2M hydrochloric acid aqueous solution, ultrasonically treat them for 10min, then use a magnet to separate and wash them for 4 times, and disperse the washed microspheres in 80mL of 20g / L glucose aqueous solution And at 190 ° C hydrothermal reaction for 5h. The product was separated with a magnet, and washed 3 times with deionized water, and the obtained magnetic carbon spheres Fe 3 o 4 @C was vacuum-dried for later use.

[0030] Weigh 1.0g of indium isopropoxide and dissolve it in 20mL of alcohol / water (volume ratio 4 / 1) solution and stir for 10min, add 0.2g of Fe obtained above 3 o 4 @C microspheres were ultrasonically oscillated for 2 min, and then the Fe adsorbed on the indium hydroxide oligomer was 3 o 4 The @C microspheres were separated and washed with ethanol for 3 times, and finally calcined at 700°C for 50-80 minutes in nitrogen to obtain microspheres w...

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Abstract

The present invention belongs to the field of inorganic material technology, and is especially one kind of magnetic metal oxide microsphere in core-shell structure and its preparation process. The microsphere has ferroferric oxide microsphere as the core and metal oxide as the shell. It is prepared through the first hydrothermal process to cover one layer of amorphous carbon onto ferroferric oxide microsphere to form magnetic carbon microsphere Fe3O4@C, the subsequent dispersing microsphere Fe3O4@C in alcohol water solution of pre-hydrolyzed metal alkoxide for adsorbing inorganic oligomer to the surface of the microsphere, and the final calcining in nitrogen atmosphere to obtain the magnetic metal oxide microsphere in core-shell structure. The process is simple and practical, and has adjustable size of the microsphere. The magnetic metal oxide microsphere has important application in separating protein, separating polypeptide and other fields.

Description

technical field [0001] The invention belongs to the technical field of inorganic materials, and in particular relates to a magnetic metal oxide microsphere with a core-shell structure and a synthesis method thereof. technical background [0002] With the rapid development of nanotechnology, nanomaterials have shown great application value in the fields of biomedicine, bioengineering, and environmental engineering. As a new type of high-efficiency separation technology, magnetic separation technology has increasingly become a hot topic in academic and industrial research. Magnetic separation technology mainly relies on a magnetically responsive microsphere or particle, which can bind to the target substance and be separated from its environment under the action of an external magnetic field, so as to achieve effective separation of the target substance . These microspheres or particles usually have a particle size between tens of nanometers and several microns, and their sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K1/14C01G49/08
Inventor 邓春晖
Owner FUDAN UNIV
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