Preparation method of nano magnetic particles for detection and treatment of coronary heart diseases

A technology of nano-magnetic particles and coronary heart disease, which is applied in preparations for in vivo experiments, cardiovascular system diseases, medical preparations with non-active ingredients, etc., can solve the problem of affecting the effect of vascular stenting treatment and the damage of vascular endothelial cell layer , It is difficult to confirm the endothelial cell layer and other problems, to achieve the effect of prolonging the detection and treatment time, improving the intensity of magnetic response imaging, and improving the sensitivity and reliability

Inactive Publication Date: 2011-06-08
CHENGDU SOUTHWEST JIAOTONG UNIV SCI & TECH GARDEN MANAGEMENT +1
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there are few methods for early diagnosis of coronary heart disease, mainly because it is difficult to identify the endothelial cell layer of the disease
Patients with middle and advanced coronary heart disease are currently mainly treated with drug-eluting vascular stents. Although this treatment can eff

Method used

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  • Preparation method of nano magnetic particles for detection and treatment of coronary heart diseases
  • Preparation method of nano magnetic particles for detection and treatment of coronary heart diseases
  • Preparation method of nano magnetic particles for detection and treatment of coronary heart diseases

Examples

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[0036] Example 1

[0037] A preparation method of nano magnetic particles for coronary heart disease detection and treatment, including the following steps:

[0038] A. Immobilize the transition layer molecules on the surface of the magnetic core. The compound mentioned is a compound containing an amino group, a carboxyl group or a mercapto group and a group capable of reacting with a hydroxyl group.

[0039] The magnetic core of this example is between 5nm in diameter, has paramagnetism, and the composition is γ-Fe 2 O 3 The transition layer molecule is dopamine.

[0040] The specific method of fixing the transition layer molecules on the surface of the magnetic core in step A of this example is: uniformly dispersing the magnetic core in the transition layer molecular aqueous solution system, the mass ratio of the magnetic core to the transition layer molecules is 1:0.05, and the fixation time is 0.5h , Magnetic separation and cleaning with deionized water.

[0041] B. Then immobilize...

Example Embodiment

[0047] Example 2-30

[0048] The preparation methods of Examples 2-30 are the same as the operation of the method of Example 1, except that: A. The magnetic core selected in each example, the mass ratio of the magnetic core / transition layer molecules, and the fixed time; B. Types of functional molecules and mass ratio of magnetic core / functional molecules / EDC / NHS of fixed transition layer molecules; C. Types of ligands specifically recognized by endothelial progenitor cells and magnetic core / specificity of fixed functional molecules The mass ratios of the identification ligand / EDC / NHS are all correspondingly replaced with the types, mass ratios, and time listed in Table 1 below (for comparison, the table also lists the data of Example 1).

[0049] Table 1: The material types, material ratios and the fixed time of the transition layer molecules selected in each step of Examples 1-30

[0050]

[0051]

[0052]

[0053]

[0054] (Note: The specific recognition ligands in Examples 29 an...

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Abstract

The invention relates to a preparation method of nano magnetic particles for detection and treatment of coronary heart diseases, which comprises the following steps: A, mixing transition layer molecules on the surfaces of magnetic nuclei, wherein the transition layer molecule are compounds which simultaneously contain amino groups, carboxyl groups or hydrosulfide groups and groups capable of reacting with hydroxyl groups; B, on the magnetic nuclei fixed with the transition layer molecules, fixing functional molecules capable of prolonging the residence time of nano particles in blood; and C, on the magnetic nuclei fixed with functional molecules, fixing specific recognition ligands of endothelial progenitor cells or diseased endothelial cells, thus obtaining the nano magnetic particles. The method can be used for preparing magnetic nano particles for early-stage detection and location of diseased endothelial cells of coronary heart diseases, and the detection is sensitive and reliable; the method can be also used for preparing magnetic nano particles for mid-late-stage treatment of coronary heart diseases; and good repairing and treatment effects on coronary heart diseases can be achieved.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials and nano-biotechnology, and in particular relates to a preparation method of nano-magnetic particles used for detection and treatment of coronary heart disease. Background technique [0002] Coronary heart disease is a frequent cardiovascular disease. The number of patients with coronary heart disease in my country is increasing at a rate of 2-4 million per year, which seriously threatens people's health and safety. The primary cause of coronary heart disease is the lesions of vascular endothelial cells, which lead to the gradual formation of plaques in the blood vessels, that is, atherosclerosis, which indicates that patients will enter the middle and late stages of coronary heart disease; plaques not only cause blood flow disorders, but also block blood vessels in severe cases and cause sudden death of patients . So far, there are few methods for early diagnosis of coronary heart dis...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/08A61K49/12A61K49/14A61K47/48A61P9/10A61K47/52A61K47/60A61K47/61A61K47/62A61K47/69
Inventor 黄楠陈佳龙王娟李全利曹建军陈卓玥熊开琴孙鸿杨苹冷永祥陈俊英王进
Owner CHENGDU SOUTHWEST JIAOTONG UNIV SCI & TECH GARDEN MANAGEMENT
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