Multifunctional double-layer core-shell structure magnetic nano particle, preparation method and application thereof

Abstract

The invention relates to a multifunctional double-layer core-shell structure magnetic nano particle. In the invention, a magnetic nano particle with a particle size of 1-300 nm is used as a core and coated with a double-layer shell consisting of a SiO2 layer with a thickness of 1-200 nm and a hydrolyzed silane coupling agent layer is 1-100 nm thick and comprises one or more multifunctional groups; the particle size and the shell layer thickness can be controlled through regulating the volumes, the weight ratios and the reaction time of the magnetic core, a silicon dioxide precursor, a silane coupling agent and a catalyst in a preparation process; the total particle size of the nano particle can be as small as 5-50 nm and as large as 700-800 nm; the nano particle can have superparamagnetism, paramagnetism and ferromagnetism according to the change of the magnetic core particle size; and one or more bioactive molecules can be connected into the shell layer of the magnetic nano particle or to the surface of the shell layer through a chemical method or a physical method. The invention also provides a preparation method of the multifunctional double-layer core-shell structure magnetic nano particle and application thereof. The particle preparation method has the advantages of simplicity, moderate condition, low cost and easy realization of industrial production. The nano particle can obtain different functions through connecting different bioactive molecules and can be applied to the fields of protein enrichment, biological detection, separation and purification, targeted drug carriers, cell imaging and medical imaging.

Description

technical field [0001] The invention belongs to the field of materials and biomedicine, and relates to a multifunctional double-layer shell-core structure magnetic nano particle and its preparation method and application. Background technique [0002] Magnetic nanoparticles have broad application prospects in the fields of biological detection and separation and purification, medical imaging, targeted drug carriers, and environmental detection. These applications require magnetic nanoparticles to have good chemical stability, dispersibility and biocompatibility, narrow particle size distribution and high magnetic responsiveness. To meet these application requirements, the surface of magnetic nanoparticles must be chemically packaged. Covering, modification and introduction of suitable functional groups. [0003] SiO 2 It has good chemical stability, biocompatibility and anti-decomposition ability, and the surface is negatively charged. Coating a layer of SiO on the surfac...

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Problems solved by technology

So far, there is no hydrolyzed silane coupling agent modified by various functional groups on the outer layer and SiO2 on the inner layer. 2 , A report on magnetic nanoparticles with a double shell-core structure and their preparation and application

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