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Chitose aquagel evoked original position synthesis of super-paramagnetism nano ferriferrous oxide particles

A ferroferric oxide and superparamagnetic technology, which is applied in the direction of iron oxide/hydroxide and ferric oxide, can solve the problems of complex chitosan methods and serious agglomeration of nanometer ferric oxide particles. Achieve good biocompatibility, mild conditions and simple equipment

Inactive Publication Date: 2008-01-30
HARBIN INST OF TECH
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  • Summary
  • Abstract
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Problems solved by technology

[0005] The purpose of the present invention is to provide a chitosan hydrogel induced in situ synthesis of superparamagnetic Nano ferric oxide particles

Method used

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  • Chitose aquagel evoked original position synthesis of super-paramagnetism nano ferriferrous oxide particles

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specific Embodiment approach 1

[0010] Specific embodiment one: present embodiment adopts chitosan hydrogel induction in situ method to synthesize superparamagnetic nano-ferric oxide particles, the steps of the method are as follows: one, chitosan powder is added in the acetic acid solution, mechanically stirred Dissolve completely to chitosan, be mixed with the light yellow chitosan solution that mass percent concentration is 2~5% homogeneity; Let stand for 8-12 hours to obtain chitosan gel; 3. Soak chitosan gel in 0.06mol / L FeCl 3 aqueous solution, water, 0.03mol / L Fe(NO 3 ) 2 aqueous solution, water, and soaking cycle three to five times, that is, the formation of chitosan hydrogel (CS-NH 2 ---Fe 2+ , Fe 3+ ); Four, immerse the aqueous solution of the chitosan hydrogel that contains iron ion to carry out alkalization treatment 5~24h, wherein NaOH mass percent concentration is 4%, adopt distilled water to rinse the magnetic chitosan hydrogel of black to medium then 5. Add the black magnetic chitosan g...

specific Embodiment approach 2

[0012] Specific embodiment two: what this embodiment is different from specific embodiment one is that in step five, the magnetic chitosan gel after step four rinsing will be added to H 2 o 2 or lysozyme solution for degradation reaction; where H 2 o 2 The volume percent concentration of the solution is 4%, and the mass percent concentration of the lysozyme solution is 0.015%. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0013] Embodiment 3: The difference between this embodiment and Embodiments 1 and 2 is that in step 2, the cross-linking agent is a physical cross-linking agent, and the physical cross-linking agent is tripolyphosphate, glycerophosphate or glycerol. Other steps are the same as those in Embodiments 1 and 2.

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Abstract

The invention provides superparamagnetic nano Fe3O4 particles synthesized through in-situ induction of chitosan hydrogels, relating to a method for synthesizing the superparamagnetic nano Fe3O4 particles. The invention solves the problems of serious aggregation of the nano Fe3O4 particles and the complicated method for inducing the chitosan into the surface of the Fe3O4 in the current nano Fe3O4 particles. The method of the invention is that: 1. the chitosan powder is added into dilute acid solution; 2. cross-linking agent is added to make the chitosan hydrogels; 3. the chitosan hydrogels are sequentially dipped in Fe3+ aqueous solution, water, Fe2+ aqueous solution and water, and a plurality of times of circular leaching are made so as to form the chitosan hydrogels that contains iron ions; 4. then basification treatment is carried out; 5. the hydrogels is dissolved or degraded again, and finally the black superparamagnetic Fe3O4 nano particles are obtained upon centrifugalization. The method of the invention requires simple technique and mild conditions and the equipment used in the method is simple and can be obtained easily, thereby mass production can be achieved. The average diameter of the particles is 15 to 25nm, and the particles distribute evenly with superparamagnetism.

Description

technical field [0001] The invention relates to a method for synthesizing superparamagnetic nanometer ferric oxide particles, in particular to a method for synthesizing superparamagnetic nanometer ferric oxide particles in situ induced by chitosan hydrogel under mild conditions. Background technique [0002] When the particle size of ferroferric oxide is less than 30nm, ferroferric oxide nanoparticles will exhibit superparamagnetism, that is, strong magnetism when an external magnetic field is applied, and coercive force and residual magnetization when the external magnetic field is removed. Intensity tends to 0. Superparamagnetic Fe3O4 nanoparticles have been widely used in biomedical fields such as magnetic cell separation, targeted drug delivery system, magnetic resonance imaging, and cancer overheating therapy. [0003] Usually the method for synthesizing ferric oxide is to add ammonia water or hydroxide ion to a certain molar ratio of ferrous iron and ferric iron ion s...

Claims

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Application Information

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IPC IPC(8): C01G49/08
Inventor 李保强王永亮周玉
Owner HARBIN INST OF TECH
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