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Methods to form substrates for optical sensing by surface enhanced raman spectroscopy (sers) and substrates formed by methods

An array substrate, vinylpyridine technology, applied in nanotechnology for sensing, material analysis by optical means, process for producing decorative surface effects, etc., can solve the problem that nanoparticle solutions cannot withstand the ionic environment of biological media , trouble, can not switch to biological environment and other issues

Inactive Publication Date: 2013-03-06
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is cumbersome and cannot be transferred to biological environments because nanoparticle solutions cannot withstand the harsh ionic environment of biological media.

Method used

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  • Methods to form substrates for optical sensing by surface enhanced raman spectroscopy (sers) and substrates formed by methods
  • Methods to form substrates for optical sensing by surface enhanced raman spectroscopy (sers) and substrates formed by methods
  • Methods to form substrates for optical sensing by surface enhanced raman spectroscopy (sers) and substrates formed by methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Example 1: Materials

[0118] Polystyrene-block-poly(2-vinylpyridine) (PS-b-PVP) (57000-b-57000 g / mol) was purchased from Polymer Source Inc. (Montreal, Canada). Silicon and quartz substrates can be purchased from Silicon Valley Microelectronics (SVM, CA, USA). (3-Aminopropyl)trimethoxysilane (APTMS, 95%) and crystal violet (CV, FW: 407.99) were purchased from Sigma-Aldrich. Hexane, ethanol (all analytical grade), hydrochloric acid (HCI, 37%), nitric acid (HNO 3 , 65%), sulfuric acid (H 2 SO 4 , 95-97%) and hydrogen peroxide (H 2 O 2 ) Purchase from Merck. An optical fiber with a diameter of 1000 μm and an aperture value of 0.37, with a hard polymer coating and a silica core was purchased from Thorlabs (BFH37-1000, fiber ID F-10-056T).

Embodiment 2

[0119] Embodiment 2: Characteristic method

[0120] The zeta potential of the surface coated with the micellar array was obtained by flow potential measurement using a SurPASS electro-dynamic analyzer (Anton Par, VA, USA). The electrophoresis measurement of the gold nano particles was performed by Zetasizer Nano ZS (Malvern, Worcestershire, UK). The sample used for measurement measures 20mm×10mm. Templates, nanoparticle clusters, and unpatterned gold nanoparticles utilize tap mode AFM (Nanoscope IV Multimode AFM, Veeco Instruments, NY, USA) working at 300kV, SEM (FESEM6700F, JEOL, Tokyo, Japan) and TEM (Philips CM300) to express. The extinction spectrum of the gold nano particles assembled on the glass substrate was recorded using a CRAIC spectrophotometer (CRAIC technology, CA, USA). The unpolarized light source uses a measurement point area of ​​77μm×77μm.

Embodiment 3

[0121] Example 3: Preparation of optical fiber substrate

[0122] The optical fiber is cut into 10 cm pieces by a cleaver. Peel off the shell and coating about 1.5 cm in length from each end. Then use alumina polishing pads (1 μm) to polish both ends by standard techniques. Then rinse the polished end with water jet for about 2 to 3 minutes, and sonic it for 10 minutes and dry.

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Abstract

A method of manufacturing a substrate is provided. The method comprises, in some aspects, a) providing a support; b) forming a template by attaching a plurality of polymeric nanoparticles some or all having a core-shell structure to the support, wherein the core comprises a first polymer and the shell comprises a second polymer; and c) forming the metal nanoarray substrate by attaching a plurality of metallic nanoparticles to at least some of the polymeric nanoparticles of the template. A biosensor comprising a substrate manufactured by the method, and a method for the detection of an analyte in a sample by surface enhanced Raman spectroscopy (SERS) is also provided.

Description

[0001] Cross references to related applications [0002] This application relates to and requires the priority rights of the application filed at the National Intellectual Property Office of Singapore on August 19, 2011, and the officially designated serial number is 201106015-9: "A method of using oriented self-assembled gold nanoparticles, in use A method for fabricating metal nano-arrays on optical fiber sockets for high-performance SERS-based telemetry of molecular analytes". The entire content of the application filed on August 19, 2011 is hereby incorporated as a reference for all purposes. Technical field [0003] The invention relates to a method of forming a substrate. In particular, the present invention relates to a method of forming a substrate for optical sensing by surface enhanced Raman spectroscopy (SERS), and a substrate formed by the method. Background technique [0004] Vibration spectroscopy techniques such as infrared (IR), standard Raman spectroscopy and surf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B81C1/00G01N21/65
CPCG01N33/54373C40B50/18G01N33/54353G01N33/54346B81B2201/0214C40B40/14C40B30/00G01N21/658B82Y30/00B81C1/00206B82Y15/00
Inventor 叶凤玲S·克里施纳莫西P·托尼约特V·苏莱士S·丁达
Owner AGENCY FOR SCI TECH & RES
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