Preparation method of chelate coating with copper ions capable of controllably catalyzing release of nitrogen monoxide and polyphenol complex

A technology of nitric oxide and copper ions, which is applied in the direction of coating, packaging item types, special packaging items, etc., can solve the problems of multi-step grafting, limited grafting amount, peeling off of the surface modified layer, etc., and achieve strengthening Antibacterial effect, low production cost, and multi-step effect

Active Publication Date: 2014-12-10
GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The multi-step of such grafting side is relatively loaded down with trivial details; And Cu 2+ It only exists in the surface layer of the modified material, and its grafting amount is limited, and with the degradation of the transition polymer layer, the surface Cu 2+ Easily peels off from the modified layer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for preparing a chelate coating with controllable nitrogen monoxide catalytic release of copper ions and polyphenol complexes, the steps of which are:

[0021] A. Dissolve dopamine (Dopamine) with a concentration of 0.1 mg / mL, copper chloride with a concentration of 1 mg / mL and ferric chloride with a concentration of 0-10 mg / mL in an aqueous solution with a pH of 2-14.

[0022] B. Fe, magnesium and its alloys, zinc and its alloys, 316L SS, Ti and its alloys, Ni-Ti alloy, CoCr alloy, Ti-O and its nanotubes, TiN, PET, PU, PS, PTFE, PDMS, PLA, PTMC, PLGA, PCL, Fe3O4 nanoparticles, (mesoporous) silica nanoparticles (quantum dots), titanium oxide nanoparticles (quantum dots), zinc oxide nanoparticles (quantum dots) point), etc., were respectively placed in the reaction system obtained by adding step A, and reacted at room temperature for 6 hours.

[0023] C, to the sample obtained in step B, fully wash with distilled water, then in N 2 Dry under the same condition...

Embodiment 2

[0025] A method for preparing a chelate coating with controllable nitrogen monoxide catalytic release of copper ions and polyphenol complexes, the steps of which are:

[0026] A. Dissolve norepinephrine with a concentration of 1 mg / mL, copper chloride with a concentration of 0.1 mg / mL and ferric chloride with a concentration of 0-10 mg / mL in an aqueous solution of pH=2-14.

[0027] B. Fe, magnesium and its alloys, zinc and its alloys, 316L SS, Ti and its alloys, Ni-Ti alloy, CoCr alloy, Ti-O and its nanotubes, TiN, PET, PU, PS, PTFE, PDMS, PLA, PTMC, PLGA, PCL, Fe3O4 nanoparticles, (mesoporous) silica nanoparticles (quantum dots), titanium oxide nanoparticles (quantum dots), zinc oxide nanoparticles (quantum dots) point) and the like were added to the reaction system obtained in step A, and reacted at room temperature for 6 hours.

[0028] C, to the sample obtained in step B, fully wash with distilled water, then in N 2 Dry under the same conditions to obtain the target modi...

Embodiment 3

[0030] A method for preparing a chelate coating with controllable nitrogen monoxide catalytic release of copper ions and polyphenol complexes, the steps of which are:

[0031] A. Dissolve tannic acid (TA) with a concentration of 0.1 mg / mL, copper chloride with a concentration of 1 mg / mL and ferric chloride with a concentration of 0-10 mg / mL in an aqueous solution of pH=2-14.

[0032] B. Fe, magnesium and its alloys, zinc and its alloys, 316L SS, Ti and its alloys, Ni-Ti alloy, CoCr alloy, Ti-O and its nanotubes, TiN, PET, PU, PS, PTFE, PDMS, PLA, PTMC, PLGA, PCL, Fe3O4 nanoparticles, (mesoporous) silica nanoparticles (quantum dots), titanium oxide nanoparticles (quantum dots), zinc oxide nanoparticles (quantum dots) point) and the like were added to the reaction system obtained in step A, and reacted at room temperature for 6 hours.

[0033] C, to the sample obtained in step B, fully wash with distilled water, then in N 2 Dry under the same conditions to obtain the target mo...

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PUM

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Abstract

The invention discloses a preparation method of a chelate coating with copper ions capable of controllably catalyzing release nitrogen monoxide and a polyphenol complex. The preparation method comprises the following steps: soaking a target modified material or an instrument in a mixed aqueous solution consisting of soluble metal salt, soluble copper salt and a compound having an o-phenol structure; and depositing a layer of chelate coating with copper ions with a function of catalyzing nitrogen monoxide and the polyphenol complex on the surface. The chelate coating with the copper ions and the polyphenol complex, which is obtained by the preparation method disclosed by the invention, not only has excellent biocompatibility and bacterial resistance, but also has a function of inducing catalysis of endogenous nitrogen monoxide to release in a blood environment. In addition, the coating is nearly applicable to surface modification of materials of all textures, complex geometrical shapes and different topological structures.

Description

technical field [0001] The invention relates to a method for preparing a chelate coating or material of copper ions and polyphenol complexes with controllable catalytic rate of nitric oxide. Background technique [0002] Divalent copper ions (Cu 2+ ) is a component of many metalloenzymes (diamine oxidase, cytochrome C oxidase, etc.) in the human body, and is an essential trace element for the human body; Cu 2+ The lack of it may even lead to embryonic hypoplasia, connective tissue defects and other diseases. Cu 2+ It has been proved to have significant antibacterial function; at the same time Cu 2+ It also has the ability to promote the formation of callus at the fracture site and inhibit the mineral tissue absorption process of the bone resorption pit on the dental grinding sheet; in addition, Cu 2+ / Cu + It also has a strong oxidation catalytic function, including nitric oxide (NO) catalytic function, that is, it can catalyze the continuous synthesis of NO donors in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D7/12C09D5/14A61L27/30A61L27/54A61L31/08A61L31/16A61L33/02
Inventor 黄楠杨志禄王进齐鹏凯涂秋芬杨莹熊开琴翁亚军李龙李亚龙
Owner GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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