Preparation of a Peptide Nanotube-Cyclic Diguanylate Complex for Tumor Therapy

By preparing c-di-GMP-PNT and c-di-GMP-PPNT complexes, using peptide nanotubes and phenylboric acid modified peptide nanotubes as carriers, the problems of poor membrane permeability and low bioavailability in tumor immunotherapy were solved, and better bioavailability and immunotherapy effects were achieved.

CN116196407BActive Publication Date: 2025-07-22HUNAN NORMAL UNIVERSITY
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Patent Information

Application Number
CN202111435863.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-11-30
Publication Date
2025-07-22
Estimated Expiration
2041-11-30

AI Technical Summary

Technical Problem

Cyclodal diguanylate has problems of poor membrane permeability and low bioavailability in tumor immunotherapy, which limits its delivery and anti-tumor effects in vivo.

Method used

Peptide nanotubes (PNT) and phenylboric acid modified peptide nanotubes (PPNT) were used as carriers to complex with cyclic diguanylate (c-di-GMP), and c-di-GMP-PPNT complexes were formed through electrostatic action, reducing their contact with phosphodiesterase, improving bioavailability and enhancing immune and anti-tumor effects.

Benefits of technology

It effectively improves the bioavailability of c-di-GMP and its retention time in the body, promotes the secretion of Type I IFN and IL-6 inflammatory factors, and enhances the effect of tumor immunotherapy.

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Abstract

The present invention discloses the preparation of a peptide nanotube-cyclic diguanosine monophosphate complex for tumor treatment, which method improves the problems of poor membrane permeability and low bioavailability of cyclic diguanosine monophosphate (c-di-GMP). Peptide nanotubes (PNT) and phenylboronic acid peptide nanotubes (PPNT) are used to deliver c-di-GMP, which can enhance the immune anti-tumor effect of c-di-GMP in vivo.
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