Analgesic antipruritic myoplastic and wound healing promoting bacteriostatic ointment and preparation method thereof

Abstract

An analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment and its preparation method are disclosed. This invention relates to the field of traditional medicine and skin antibacterial preparations. It comprises the following components by weight: 400-600 parts sesame oil, 30-80 parts beeswax, 25-100 parts a plant-based medicinal composition, 5-25 parts an animal-based medicinal composition, 1-5 parts a mineral-based medicinal composition, and 0.1-0.3 parts an antibacterial agent. The plant-based medicinal composition includes elm branches, willow branches, purple gromwell root, and jujube branches; the animal-based medicinal composition includes dragon's blood and earthworm; the mineral-based medicinal composition is red silver pearl powder; and the antibacterial agent is chlorhexidine acetate. Using pure natural Chinese medicinal herbs as core raw materials, with a reasonable formulation and stable preparation process, it has rapid analgesic, antipruritic, hemostatic, antibacterial, tissue-regenerating, and wound-healing effects. It has significant effects on acute trauma, burns, and chronic, difficult-to-heal wounds, is safe and non-irritating, and has controllable quality.

Description

Technical Field

[0001] This invention relates to the field of traditional medicine and antibacterial skin preparations, specifically to an analgesic, antipruritic, tissue-regenerating, wound-healing antibacterial ointment and its preparation method. Background Technology

[0002] Traumatic wounds, especially open injuries, burns, and chronic, non-healing wounds (such as diabetic foot, bedsores, and lower extremity venous ulcers, commonly known as chronic leg ulcers), are common clinical conditions that seriously affect patients' quality of life.

[0003] Currently, the mainstream clinical treatment for traumatic wounds in Western medicine mainly involves debridement, drainage strips, and antibiotics to control infection. Wound healing relies heavily on the patient's own repair capabilities, resulting in drawbacks such as long healing periods, easy recurrence of infection, easy scarring, and high treatment costs. This is especially true for chronic and difficult-to-heal wounds such as diabetic foot and severe pressure ulcers, which may even lead to amputation. On the other hand, commercially available traditional Chinese medicine ointments generally suffer from slow onset of action, limited indications, loss of traditional preparation techniques, and poor quality control. At the same time, there is a misconception among the public that "traditional Chinese medicine is slower to take effect than Western medicine," which leads to great difficulties in the inheritance and promotion of traditional trauma diagnosis and treatment methods, and folk remedies and processing techniques are on the verge of extinction. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings and deficiencies of existing technologies by providing an analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment and its preparation method. This solves the problems of slow onset of action, long healing cycle, narrow indications, and poor quality control in existing wound treatment products. The antibacterial ointment uses pure natural Chinese medicinal herbs as its core raw materials, with a reasonable formulation and stable preparation process. It has the effects of rapid analgesia, antipruritic, hemostasis, antibacterial, tissue-regenerating, and wound-healing. It has significant effects on acute trauma, burns, and chronic, difficult-to-heal wounds. It is safe, non-irritating, and has controllable quality.

[0005] To achieve the above objectives, the analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment of the present invention comprises the following components by weight: 400-600 parts sesame oil, 30-80 parts beeswax, 25-100 parts herbal medicine composition, 5-25 parts animal medicine composition, 1-5 parts mineral medicine composition, and 0.1-0.3 parts antibacterial agent; wherein, the herbal medicine composition includes elm branches, willow branches, purple gromwell root, and jujube branches; the animal medicine composition includes dragon's blood and earthworm; the mineral medicine composition is red silver pearl powder; and the antibacterial agent is chlorhexidine acetate.

[0006] Furthermore, the herbal medicine composition comprises, by weight, 10-30 parts of elm branches, 10-30 parts of willow branches, 5-20 parts of gromwell root, and 5-20 parts of jujube branches.

[0007] Furthermore, the animal drug composition comprises, by weight, 3-15 parts of dragon's blood and 2-10 parts of earthworm.

[0008] Furthermore, the analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment, when used as a basic general-purpose antibacterial ointment, comprises, by weight: 500 parts sesame oil, 50 parts beeswax, 20 parts elm branches, 20 parts willow branches, 10 parts purple gromwell root, 10 parts jujube branches, 8 parts dragon's blood, 5 parts earthworm, 3 parts red silver pearl powder, and 0.15 parts chlorhexidine acetate.

[0009] Furthermore, the analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment, when used as a special antibacterial ointment for burns and scalds, comprises, by weight: 500 parts sesame oil, 45 parts beeswax, 15 parts elm branches, 15 parts willow branches, 20 parts purple gromwell root, 8 parts jujube branches, 12 parts dragon's blood, 4 parts earthworm, 2 parts red silver pearl powder, and 0.18 parts chlorhexidine acetate.

[0010] Furthermore, the analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment, when used as a special antibacterial ointment for diabetic foot, comprises, by weight: 500 parts sesame oil, 55 parts beeswax, 20 parts elm branches, 18 parts willow branches, 12 parts purple gromwell root, 12 parts jujube branches, 10 parts dragon's blood, 6 parts earthworm, 3 parts red silver pearl powder, 15 parts astragalus, 8 parts coptis, and 0.2 parts chlorhexidine acetate.

[0011] The preparation method of the analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment of the present invention includes the following steps: Step 1, Raw material pretreatment: Weigh each ingredient according to the formula. Wash and remove impurities from elm branches, willow branches, jujube branches, and purple gromwell. After drying, cut them into 2-3cm sections and set aside. Crush dragon's blood and earthworm into powder and pass through a 100-mesh sieve to obtain fine powder and set aside. Step 2, preparing the medicinal oil: Add the prescribed amount of sesame oil to the reaction vessel, heat to 110-120℃, add the herbal medicine composition processed in step 1, simmer over low heat for 30-60 minutes until the herbs turn dark yellow, filter through a 200-mesh filter cloth to remove the dregs, and obtain refined medicinal oil. Step 3: Mixing fine materials: Cool the refined medicinal oil obtained in step 2 to 80-90℃, add the prescribed amounts of red silver pearl powder, blood dragon fine powder, and earthworm fine powder, and stir at a constant temperature for 20-40 minutes until the materials are completely dispersed and dissolved to obtain the mixed medicinal oil. Step 4, ointment filling: Add the prescribed amount of beeswax to the mixed pharmaceutical oil obtained in step 3, stir at a constant temperature until the beeswax is completely melted, continue to cool down to below 40°C, add the prescribed amount of chlorhexidine acetate, stir evenly, and fill in a Class 100 sterile environment to obtain the antibacterial ointment.

[0012] Compared with the prior art, the beneficial effects of the present invention are: 1. The formula is based on an intangible cultural heritage prescription and is scientifically and rationally formulated: using sesame oil and beeswax as the base, it follows the traditional Chinese medicine concept of "moist healing" to provide a closed and suitable repair environment for the wound; elm branches, willow branches, purple gromwell, and jujube branches clear heat and detoxify, cool blood and reduce swelling, remove necrotic tissue and promote tissue regeneration; dragon's blood and earthworm invigorate blood circulation, remove blood stasis, unblock meridians and relieve pain, and promote wound healing; red and silver pearl powder detoxifies, kills insects, absorbs moisture and relieves itching, removes necrotic tissue and promotes tissue regeneration; chlorhexidine acetate is added to enhance the antibacterial effect. The whole formula works together to relieve pain and itching, stop bleeding and promote tissue regeneration, inhibit bacteria and reduce inflammation, and promote wound healing. It has multiple effects in one and a wide range of applications.

[0013] 2. Rapid onset of action and significant therapeutic effect: The antibacterial ointment of this invention can significantly relieve wound pain and itching within 10 minutes, and obvious wound healing effect can be seen in 2-3 days; it can be used at home to treat open wounds less than 3cm and insect bites; for chronic and difficult-to-heal wounds such as perforated wounds, bedsores, diabetic foot, and lower extremity venous ulcers, it can quickly promote the growth of granulation tissue, smooth the wound surface, reduce the probability of scarring, shorten the healing cycle, significantly reduce treatment costs, avoid the risk of amputation for patients, and break the inherent perception that "traditional Chinese medicine is slower to take effect than Western medicine".

[0014] 3. Safe, reliable, and widely applicable: Made with pure natural Chinese medicinal herbs as the core raw materials, without any irritating chemical additives, it is gentle and non-irritating, suitable for all skin types; clinically proven to have good inhibitory effects on Escherichia coli, Staphylococcus aureus, and Candida albicans, it can effectively prevent wound infection and is suitable for acute wounds such as abrasions, burns, cuts, and postoperative injuries, as well as various skin and wound conditions such as lower extremity venous ulcers, diabetic foot, bedsores, frostbite, insect bites, and dermatitis.

[0015] 4. Stable preparation process and controllable quality: Based on the inheritance of traditional decoction process, the parameters such as decoction temperature, time and order of adding materials have been optimized to achieve standardized production of preparations. The product quality is stable and controllable. At the same time, the effective components of traditional Chinese medicine are fully preserved, taking into account both the inheritance of intangible cultural heritage and the requirements of modern preparation standards, which facilitates large-scale production and promotion. Attached Figure Description

[0016] Figure 1 This is a comparison table of the antibacterial effects of each experimental group.

[0017] Figure 2 This is a comparison of wound healing rates at different time points in different groups of rats (x±s, n=10, %).

[0018] Figure 3 This is a comparison of pain thresholds before and after drug administration in each group of rats (x±s, n=10, g).

[0019] Figure 4Table 1 shows a comparison of the treatment effects of clinical cases in this invention.

[0020] Figure 5 Table 2 shows a comparison of the treatment effects of clinical cases in this invention. Detailed Implementation

[0021] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. The preferred embodiments described are only examples. All other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0022] Example 1: The analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment provided in this embodiment is a basic general-purpose antibacterial ointment. Its raw material components, by weight, are: 500 parts sesame oil, 50 parts beeswax, 20 parts elm branches, 20 parts willow branches, 10 parts purple gromwell root, 10 parts jujube branches, 8 parts dragon's blood, 5 parts earthworm, 3 parts red silver pearl powder, and 0.15 parts chlorhexidine acetate.

[0023] The preparation method of this embodiment includes the following steps: Step 1: Raw material pretreatment: Weigh each raw material according to the formula. Wash and remove impurities from elm branches, willow branches, jujube branches, and purple gromwell. After air drying, cut them into 2-3cm sections for later use. Use an ultra-fine pulverizer to grind the blood dragon and earthworm into fine powder through a 100-mesh sieve for later use. Step 2, Medicinal Oil Preparation: Add the prescribed amount of sesame oil to a stainless steel reactor, heat to 115℃, add the elm branches, willow branches, jujube branches and purple gromwell root processed in Step 1, simmer over low heat for 45 minutes until the surface of the medicinal materials is charred yellow and the inside is charred yellow without white core, filter with a 200-mesh sterile filter cloth to remove the dregs, and obtain refined medicinal oil. Step 3, fine material mixing: Cool the refined medicinal oil obtained in Step 2 to 85℃, add the formula amount of red silver pearl powder, blood dragon fine powder and earthworm fine powder, stir at constant temperature for 30 minutes, stirring rate is 30r / min, until the materials are completely dispersed and dissolved, and there is no visible sediment, to obtain the mixed medicinal oil. Step 4, ointment filling: Add the prescribed amount of beeswax to the mixed pharmaceutical oil obtained in Step 3, stir at a constant temperature of 85°C until the beeswax is completely melted, continue to circulate cooling water to cool down to 38°C, add the prescribed amount of chlorhexidine acetate, stir for 15 minutes until completely mixed, fill into 15g sterile ointment tubes under a Class 100 aseptic environment, seal, and the antibacterial ointment of this embodiment is obtained.

[0024] The antibacterial ointment prepared in this embodiment is a uniform red ointment with a slightly fragrant odor and no visible foreign matter. It is suitable for various general external injuries and skin wounds, such as mosquito bites, abrasions, cuts, bedsores, chronic leg ulcers, and perforated wounds.

[0025] Example 2: The analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment provided in this embodiment is used as a special antibacterial ointment (Zi Yi) for burns and scalds. Its raw material components by weight are: 500 parts sesame oil, 45 parts beeswax, 15 parts elm branches, 15 parts willow branches, 20 parts purple gromwell root, 8 parts jujube branches, 12 parts dragon's blood, 4 parts earthworm, 2 parts red silver pearl powder, and 0.18 parts chlorhexidine acetate.

[0026] The preparation method in this embodiment is basically the same as that in Example 1, except that the cooking time in step 2 is 40 minutes.

[0027] The antibacterial ointment prepared in this embodiment is a uniform purplish-red ointment with a slightly fragrant odor and no visible foreign matter. It enhances the effects of promoting tissue regeneration, relieving pain, and astringing wounds. It is suitable for new wounds such as burns of grades 1-4 and postoperative wound healing. It can quickly relieve pain and reduce scar formation.

[0028] Example 3: The analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment provided in this embodiment is used as a special antibacterial ointment for diabetic foot (Sugar 1). Its raw material components by weight are: 500 parts sesame oil, 55 parts beeswax, 20 parts elm branches, 18 parts willow branches, 12 parts purple gromwell root, 12 parts jujube branches, 10 parts dragon's blood, 6 parts earthworm, 3 parts red silver pearl powder, 15 parts astragalus, 8 parts coptis, and 0.2 parts chlorhexidine acetate.

[0029] The preparation method in this embodiment includes the following steps: Step 1: Raw material pretreatment: Weigh each raw material according to the formula. Wash and remove impurities from elm branches, willow branches, jujube branches, purple gromwell, astragalus, and coptis. After air drying, cut them into 2-3cm sections for later use. Use an ultra-fine pulverizer to grind the blood dragon and earthworm into fine powder through a 100-mesh sieve for later use. Step 2, Medicinal Oil Preparation: Add the prescribed amount of sesame oil to a stainless steel reactor, heat to 115℃, add the elm branches, willow branches, jujube branches, purple gromwell, astragalus, and coptis treated in step S1, and simmer over low heat for 50 minutes until the surface of the medicinal materials is dark yellow and the inside is dark yellow without any white core. Filter the mixture with a 200-mesh sterile filter cloth to remove the dregs and obtain the refined medicinal oil. Step 3, fine material mixing: Cool the refined medicinal oil obtained in Step 2 to 85℃, add the formula amount of red silver pearl powder, blood dragon fine powder and earthworm fine powder, stir at constant temperature for 30 minutes, stirring rate is 30r / min, until the materials are completely dispersed and dissolved, and there is no visible sediment, to obtain the mixed medicinal oil. Step 4, ointment filling: Add the prescribed amount of beeswax to the mixed pharmaceutical oil obtained in Step 3, stir at a constant temperature of 85°C until the beeswax is completely melted, continue to circulate cooling water to cool down to 38°C, add the prescribed amount of chlorhexidine acetate, stir for 15 minutes until completely mixed, fill into 15g sterile ointment tubes under a Class 100 aseptic environment, seal, and the antibacterial ointment of this embodiment is obtained.

[0030] The antibacterial ointment prepared in this embodiment is a uniform reddish-brown ointment with a slightly fragrant odor and no visible foreign matter. In view of the difficulty in wound healing in the high-sugar environment of diabetic patients, astragalus and coptis are added to replenish qi and blood, clear heat and detoxify, and improve microcirculation. It can effectively improve local sugar metabolism in the wound and promote the healing of diabetic foot and external wounds in diabetic patients.

[0031] Compared with the prior art, the beneficial effects of the present invention are: it provides an analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment and its preparation method, solving the problems of slow onset of action, long healing cycle, narrow indications, and poor quality control of existing wound treatment products; the antibacterial ointment uses pure natural Chinese medicinal materials as core raw materials, with reasonable formulation and stable preparation process, and has the effects of rapid analgesia, antipruritic, hemostasis, antibacterial, tissue-regenerating, and wound-healing. It has significant effects on acute trauma, burns, and chronic, difficult-to-heal wounds, is safe and non-irritating, and has controllable quality.

[0032] Controlled experiment: Purchase commercially available classic Shengji Yuhong Ointment as a comparative example of traditional Chinese medicine; The treatment regimen commonly used in clinical practice, consisting of iodine debridement, mupirocin ointment application, and sterile gauze bandaging, was used as the Western medicine comparison ratio 2.

[0033] 1. In vitro antibacterial effect test: Referring to the 2002 edition of the "Disinfection Technical Specifications", the in vitro antibacterial efficacy of the antibacterial ointments in Examples 1-3 and Comparative Example 1 was tested. The test strains were Escherichia coli ATCC25922, Staphylococcus aureus ATCC6538, and Candida albicans ATCC10231. The contact time was 2 minutes, and the test was repeated 3 times. The average value was taken. The results are shown in […]. Figure 1 .

[0034] from Figure 1 It can be seen that the antibacterial ointments prepared in Examples 1-3 of this invention have extremely strong inhibitory effects on Escherichia coli, Staphylococcus aureus, and Candida albicans, with antibacterial rates all higher than 98%, which is significantly better than the commercially available traditional Shengji Yuhong Ointment. It can effectively prevent wound infection and provide a sterile environment for wound healing.

[0035] 2. Acute wound healing effect test in rats: Sixty SPF-grade SD rats, half male and half female, weighing 200±20g, were selected. After acclimatization for 3 days, acute skin defects with a diameter of 2cm were created on both sides of the spine on the back of the rats. They were randomly divided into 6 groups with 10 rats in each group: Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Model Control Group (debridement with saline followed by sterile gauze dressing).

[0036] Administration method: Once daily after debridement, the corresponding antibacterial ointment was applied to groups 1-3 of the Examples; Shengji Yuhong Ointment was applied to group 1 of the Comparative Example; and iodine tincture + mupirocin ointment was used to group 2 of the Comparative Example. The model control group received only saline debridement. Wound healing rates and complete wound healing time were recorded at 3, 7, and 14 days after administration. Results are shown below. Figure 2 Simultaneously, the change in pain threshold 10 minutes after drug administration was recorded to evaluate the analgesic effect. The results are shown in […]. Figure 3 .

[0037] from Figure 2 , Figure 3 It can be seen that the antibacterial ointment of Examples 1-3 of the present invention can significantly improve the healing rate of acute wounds in rats and shorten the time to complete healing. A healing rate of more than 30% can be achieved after 3 days of administration, and almost complete healing can be achieved after 14 days, which is significantly better than Comparative Examples 1 and 2. At the same time, the pain threshold of rats can be significantly increased after 10 minutes of administration, and the analgesic effect is significant. Among them, Example 2 has the best analgesic and healing-promoting effect on burns, which is consistent with the formulation design goal.

[0038] 3. Clinical case verification of treatment efficacy: Two hundred patients with various types of wounds admitted between 2023 and 2024 were selected, including 60 cases of acute trauma (abrasions and cuts), 40 cases of burns, 30 cases of bedsores, 30 cases of diabetic foot, 20 cases of lower extremity venous ulcers (chronic leg ulcers), and 20 cases of insect bites. They were randomly divided into a treatment group of 150 patients (treated with the antibacterial ointment of the corresponding embodiment of the present invention) and a control group of 50 patients (treated with the routine clinical protocol of Comparative Example 2).

[0039] Treatment methods: After debridement according to the standard debridement method, the treatment group selected the corresponding antibacterial ointment according to the wound type and changed the dressing according to the standard (wounds less than 5cm were dressed once every 3 days, wounds 5-10cm were dressed once every 2 days, and wounds more than 10cm were dressed once a day); the control group was treated with routine debridement + iodine disinfection + mupirocin ointment + sterile bandaging.

[0040] Criteria for evaluating therapeutic efficacy: Complete healing: The wound has completely healed, the scab has fallen off, and there is no redness, swelling, or pain. Significant effect: wound shrinkage ≥75%, fresh granulation tissue, no infection, and significant relief of pain and itching; Effective: Wound size reduced by ≥30%, infection controlled, and pain and itching relieved; Ineffective: The wound shows no significant change or even worsens, and the infection is not controlled.

[0041] Treatment results are shown Figures 4-5 .

[0042] from Figures 4-5 As can be seen, the antibacterial ointment of this invention has a total effective rate of 100% for various acute and chronic wounds, with a significantly higher cure rate than the control group. The average healing time is shortened by more than 50% compared to the control group. It is particularly effective for chronic, difficult-to-heal wounds such as diabetic foot, bedsores, and chronic leg ulcers, and its efficacy is completely consistent with the clinical cases recorded in the application materials, verifying the clinical effectiveness of the antibacterial ointment of this invention. Furthermore, no adverse reactions such as allergies or irritation were observed in clinical application, proving that the antibacterial ointment of this invention is safe, reliable, gentle, and non-irritating, suitable for use by people with all skin types.

[0043] For those skilled in the art, modifications can be made to the technical solutions described in the foregoing embodiments, and equivalent substitutions can be made to some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this invention should be included within the protection scope of this invention.

Claims

1. An analgesic antipruritic skin-restoring wound-healing-promoting bacteriostatic ointment, characterized in that: It comprises the following components by weight: 400-600 parts sesame oil, 30-80 parts beeswax, 25-100 parts herbal medicine composition, 5-25 parts animal medicine composition, 1-5 parts mineral medicine composition, and 0.1-0.3 parts antibacterial agent; wherein, the herbal medicine composition includes elm branches, willow branches, purple gromwell, and jujube branches; the animal medicine composition includes dragon's blood and earthworm; the mineral medicine composition is red silver pearl powder; and the antibacterial agent is chlorhexidine acetate. ​ 2. The analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment according to claim 1, characterized in that: The herbal medicine composition, by weight, includes 10-30 parts of elm branches, 10-30 parts of willow branches, 5-20 parts of gromwell root, and 5-20 parts of jujube branches.

3. The analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment according to claim 2, characterized in that: The animal drug composition, by weight, includes 3-15 parts of dragon's blood and 2-10 parts of earthworm.

4. The analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment according to claim 3, characterized in that: When used as a basic general-purpose antibacterial ointment, it comprises, by weight: 500 parts sesame oil, 50 parts beeswax, 20 parts elm branches, 20 parts willow branches, 10 parts purple gromwell root, 10 parts jujube branches, 8 parts dragon's blood, 5 parts earthworm, 3 parts red silver pearl powder, and 0.15 parts chlorhexidine acetate.

5. The analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment according to claim 3, characterized in that: When used as a special antibacterial ointment for burns and scalds, it comprises, by weight: 500 parts sesame oil, 45 parts beeswax, 15 parts elm branches, 15 parts willow branches, 20 parts purple gromwell root, 8 parts jujube branches, 12 parts dragon's blood, 4 parts earthworm, 2 parts red silver pearl powder, and 0.18 parts chlorhexidine acetate.

6. The analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment according to claim 3, characterized in that: When used as a special antibacterial ointment for diabetic foot, it comprises, by weight: 500 parts sesame oil, 55 parts beeswax, 20 parts elm branches, 18 parts willow branches, 12 parts purple gromwell root, 12 parts jujube branches, 10 parts dragon's blood, 6 parts earthworm, 3 parts red silver pearl powder, 15 parts astragalus, 8 parts coptis, and 0.2 parts chlorhexidine acetate.

7. A method for preparing an analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment, comprising the following steps: Step (1), Raw material pretreatment: Weigh each ingredient according to the formula. Wash and remove impurities from elm branches, willow branches, jujube branches, and purple gromwell. After drying, cut them into 2-3cm sections and set aside. Crush dragon's blood and earthworm into powder and pass through a 100-mesh sieve to obtain fine powder and set aside. Step (2), preparing the medicinal oil: Add the prescribed amount of sesame oil to the reaction vessel, heat to 110-120℃, add the herbal medicine composition processed in step 1, simmer over low heat for 30-60 minutes until the herbs turn dark yellow, filter through a 200-mesh filter cloth to remove the dregs, and obtain refined medicinal oil. Step (3), mixing of fine materials: Cool the refined medicinal oil obtained in step (2) to 80-90℃, add the formula amount of red silver pearl powder, blood dragon fine powder and earthworm fine powder, stir at constant temperature for 20-40 minutes until the materials are completely dispersed and dissolved to obtain mixed medicinal oil; Step (4), ointment filling: Add the prescribed amount of beeswax to the mixed medicinal oil obtained in step (3), stir at a constant temperature until the beeswax is completely melted, continue to cool down to below 40°C, add the prescribed amount of chlorhexidine acetate, stir evenly, and fill in a Class 100 sterile environment to obtain the antibacterial ointment.

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