Method for preparing psoralen and isopsoralen

A technology of isopsoralen and psoralen, applied in the field of Chinese herbal medicine chemical drug manufacturing, can solve the problem of anti-cancer mechanism and practice that no one has done in-depth research and so on.

Inactive Publication Date: 2003-10-08
SHANGHAI UNIV
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  • Abstract
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Problems solved by technology

However, whether psoralen and isopsoralen as Chinese herbal medicines can be used as anti

Method used

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Embodiment

[0019] Example: 300 g of psoraleae was pulverized, passed through a 60-mesh sieve, extracted 3 times with chloroform at room temperature, 1 liter each time, combined the extracts, and recovered the solvent under vacuum at a temperature of 60° C. and a pressure of 0.1 MPa. To obtain 23.4 grams of chloroform extract, mix the chloroform extract with 40 g of silica gel, dry it at low temperature, grind it finely, and put it on a chromatographic column (400 g of silica gel, 200-300 mesh). Gradient elution with different ratios of petroleum ether-ethyl acetate mixed solution, when the ratio of petroleum ether-ethyl acetate is 8:2, 142.5 mg of psoralen and 315.2 mg of isopsoralen were isolated.

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Abstract

A process for preparing ficusin and isoficusin used to prepare the medicine for preventing and treating gastric cancer includes pulverizing psoralea as raw material, immersion extracting in chloroform three times, vacuumizing, recovering solvent to obtain extract, adding silica gel, stirring, low-temp baking, grinding, separation extracting by chromatographic column, gradient eluting with petroleum ether-ethyl acetate solution, vacuum distilling, and laying aside for crystallizing.

Description

technical field [0001] The invention relates to a method for producing psoralen and isopsoralen, which is prepared from leguminous plant psoralen and belongs to the field of Chinese herbal medicine chemical drug production. Background technique [0002] Among the plants in nature, the leguminous plant Psoraleae has been recognized and used as a Chinese herbal medicine; its medicinal part is generally the dried ripe fruit of Psoraleae. It is used as a traditional Chinese medicine in traditional Chinese medicine, mainly because it has the effects of nourishing the kidney and strengthening yang, warming the spleen and stopping diarrhea. Foreign scholars have done a lot of research on its chemical components, the main components are coumarins, flavonoids and chalcones, but there are few studies on its coumarin components in my country. [0003] The research on psoralen, at home and abroad, generally focuses on the effect on the cardiovascular system, the antibacterial effect, t...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P35/00C07D493/04
Inventor 翁新楚吴侯郭江宁
Owner SHANGHAI UNIV
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