Malaytea scurfpea fruit extract, pharmaceutical composition containing the same, and preparation method and application thereof

A technology of psoralen extract and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of safety pollution, organic solvent pollution, and the inability to be popularized and used by pharmaceutical factories, and achieve the goal of combining strong effect

Active Publication Date: 2009-04-15
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application 200680024989.3 "The composition of bakuchiol and its preparation method" provides a method for purifying bakuchiol by using polystyrene macroporous adsorption resin. Through comparison, it is found that CG-161cd resin can purify psoralen However, there are still many problems, such as the need to use petroleum ether to extract medicinal materials, the cost is high and the safety and pollution problems are serious. On the other hand, methanol needs to be used as the elution solvent for the resin, which cannot be popularized and used in pharmaceutical factories, and the organic solvent pollution is serious.

Method used

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  • Malaytea scurfpea fruit extract, pharmaceutical composition containing the same, and preparation method and application thereof
  • Malaytea scurfpea fruit extract, pharmaceutical composition containing the same, and preparation method and application thereof
  • Malaytea scurfpea fruit extract, pharmaceutical composition containing the same, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, the preparation of psoraleae extract of the present invention

[0038] Grind 1 kg of psoraleae medicinal material (purchased from Henan Xinyang Medicinal Material Company) into coarse powder (without sieve), add 10 liters of 95% ethanol to soak overnight, reflux extraction for 2 hours, pour out the extract, add 10 Reflux extraction with 95% ethanol for 2 hours, combine the extracts and filter, recover the ethanol from the filtrate until completely dissolved, add 3% aqueous sodium hydroxide solution under constant stirring until completely dissolved, filter the solution, add 10% hydrochloric acid to the filtrate while stirring To pH value 8-9, filter after standing overnight, the macroporous adsorption resin (D101) (D101) (Chemical Plant of Tianjin Nankai University) that the gained solid is dissolved completely with 3% aqueous sodium hydroxide solution, flow velocity 2h / BV ( BV: resin bed volume=1000 milliliters), upper column is finished and rinses with ...

Embodiment 2

[0039] Embodiment 2, the preparation of psoraleae extract of the present invention

[0040]Grind 1 kg of psoraleae medicinal material (purchased from Henan Xinyang Pharmaceutical Co., Ltd.) into coarse powder (without sieve), add 10 liters of 80% ethanol to soak overnight, reflux extraction for 2 hours, pour out the extract, add 10 80% ethanol was extracted under reflux for 2 hours, the extracts were combined and filtered, and the ethanol was recovered from the filtrate until it was exhausted, and 3% aqueous sodium hydroxide solution was added under continuous stirring until it was completely dissolved. After the solution was filtered, 10% hydrochloric acid was added to the filtrate while stirring To pH value 8-9, filter after standing overnight, the macroporous adsorption resin (D101) (D101) (Chemical Plant of Tianjin Nankai University) that the gained solid is dissolved completely with 3% aqueous sodium hydroxide solution, flow velocity 2h / BV ( BV: resin bed volume = 1000 ...

Embodiment 3

[0041] Embodiment 3, the preparation of psoraleae extract of the present invention

[0042] Grind 1 kg of psoraleae medicinal material (purchased from Henan Xinyang Pharmaceutical Co., Ltd.) into coarse powder (without sieve), add 10 liters of 80% ethanol to soak overnight, reflux extraction for 2 hours, pour out the extract, add 10 80% ethanol was extracted under reflux for 2 hours, the extracts were combined and filtered, and the ethanol was recovered from the filtrate until it was exhausted, and 3% aqueous sodium hydroxide solution was added under continuous stirring until it was completely dissolved. After the solution was filtered, 10% hydrochloric acid was added to the filtrate while stirring To the pH value of 8-9, filter after standing overnight, and the obtained solid is completely dissolved with 3% aqueous sodium hydroxide solution, and then the pretreated macroporous adsorption resin (AB-8) (chemical plant of Nankai University, Tianjin), flow rate 2h / BV (BV: resi...

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Abstract

The invention relates to malaytea scurfpea extract, a medical composition containing the malaytea scurfpea extract, a preparation method for the medical composition and application of the medical composition. The malaytea scurfpea extract comprises 40 to 90 percent of malaytea scurfpea phenol and 2 to 10 percent of malaytea scurfpea flavonoid compositions, and does not comprise psoralen and isopsoralen. As proved by experiments, the malaytea scurfpea extract and the medical composition containing the malaytea scurfpea extract have stronger comprehensive function on estrogen beta receptors, and have better synergistic effect, so that the malaytea scurfpea extract and the medical composition containing the malaytea scurfpea extract are predicted to be used for treating climacteric syndrome, breast carcinoma and / or cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a plant extract, a pharmaceutical composition containing it, a preparation method and use thereof. Specifically, the present invention relates to psoraleae extract, a pharmaceutical composition containing it, a preparation method and use thereof. Background technique [0002] Psoralen is the dry and mature fruit of Psoralea corylifolia L., a leguminous plant. It is warm in nature and pungent in taste. Indications for impotence due to kidney deficiency, cold pain in the waist and knees, spermatorrhea, enuresis, frequent urination, diarrhea before dawn, cough due to deficiency and cold; external use for treating vitiligo. Modern studies have shown that psoraleae has physiological activities such as anti-oxidation, antibacterial, anti-tumor, boosting blood pressure, inducing melanocyte migration, and estrogen-like effects. Chinese patent application 200610027643.0 "Application of Bakuchiol Compounds" also introduces the applicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/487A61P9/00A61P15/12A61P15/14A61P35/00A61K131/00
Inventor 高秀梅苏艳芳王虹刘二伟辛丹王跃飞杨静王怡樊官伟张伯礼
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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