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Fructus psoraleae extract and preparation method and application thereof

A technology of psoralen extract and psoralen, which is applied in bone diseases, drug combinations, and pharmaceutical formulations, and can solve problems such as low yield of bakuchiol, loss of bakuchiol, complex process, etc.

Inactive Publication Date: 2016-02-17
SINPHAR TIAN LI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in the preparation method, as the method for preparing bakuchiol in the patent 200680024989.3 "composition of bakuchiol and its preparation method" adopts a large amount of organic solvents, such as organic solvents such as sherwood oil to extract, in safety and environment Pollution brings bigger influence, and the yield of its gained bakuchiol is lower simultaneously (bakuchiol in the raw material: bakuchiol=23-37% in the product), promptly the bakuchiol in the raw material is in There are more losses in the preparation process, which is not an ideal production process
Patent 200810182713.9 "Bakuchiol Extract, Pharmaceutical Composition Containing It, Preparation Method and Use" has the highest bakuchiol content of 71%, and its extract yield is 6.99% (bakuchiol: medicinal material) , but the process is constantly adjusting the acid and base, the process is more complicated, because the instability of bakuchiol in the strong alkaline system for a long time will cause the loss of bakuchiol in the raw material, so there is still a further improvement in the supplementation of the product The space of bone fat content and yield, so that the preparation process is more suitable for industrial production

Method used

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  • Fructus psoraleae extract and preparation method and application thereof
  • Fructus psoraleae extract and preparation method and application thereof
  • Fructus psoraleae extract and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 4000mL80-85% ethanol to soak 500g of psoraleae medicinal material (purchased from Southern Medicinal Materials Co., Ltd.) overnight, reflux extraction for 2 hours, extract twice, pour out the extract, add 4000mL80-85% ethanol to reflux extraction for 2 After hours, the extracts were combined and filtered, and the filtrate was reclaimed ethanol to the utmost, and 0.2% aqueous sodium hydroxide solution was added under constant stirring until completely dissolved, then hydrolyzed at room temperature for 30 minutes, and the pretreated macroporous adsorption resin (D101) (Tianjin Nankai University Chemical Plant), flow rate 1h / BV (BV: resin bed volume), rinse with 6BV of deionized water after loading, then rinse the resin with 2BV of 60% ethanol, and finally elute with 4BV of 95% ethanol, and concentrate the eluent to recover ethanol Until the oily psoralen extract of the present invention 63.5g, batch number B-1.

Embodiment 2

[0035] Add 500g of psoraleae medicinal material (purchased from Southern Medicinal Materials Co., Ltd.), add 4000mL80-85% ethanol to soak overnight, reflux extraction for 2 hours, extract 3 times, pour out the extract, add 4000mL80-85% ethanol to reflux extraction for 2 hour, the extracts were combined and filtered, the filtrate was reclaimed ethanol to the utmost, and 0.5% sodium hydroxide aqueous solution was added under constant stirring to completely dissolve and then hydrolyzed at room temperature for 40min, and the pretreated macroporous adsorption resin (D101) (Tianjin Nankai University Chemical Plant), flow rate 1-2h / BV (BV: resin bed volume), wash the column with 6BV deionized water, then wash the resin with 2BV60% ethanol, and finally elute with 4BV95% ethanol, and concentrate the eluent Recover the ethanol to obtain 61.8g of oily psoraleae extract of the present invention, batch number B-2.

Embodiment 3

[0037] Add 4000mL80-85% ethanol to soak 500g of psoraleae medicinal material (purchased from Southern Medicinal Materials Co., Ltd.) overnight, reflux extraction for 2 hours, extract twice, pour out the extract, add 4000mL80-85% ethanol to reflux extraction for 2 hour, the extracts were combined and filtered, and the ethanol was recovered from the filtrate to the utmost, and 1% sodium hydroxide aqueous solution was added under constant stirring to completely dissolve and then hydrolyzed at room temperature for 60 minutes, and the pretreated macroporous adsorption resin (D101) (Nankai, Tianjin) was directly applied. University Chemical Plant), flow rate 1-2h / BV (BV: resin bed volume), wash the column with 6BV deionized water, then wash the resin with 2BV60% ethanol, and finally elute with 4BV95% ethanol, the eluent is concentrated and recovered Ethanol until the oily psoralen extract of the present invention is 61.6g, batch number B-3.

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Abstract

The invention relates to a fructus psoraleae extract. The fructus psoraleae extract does not contain psoralen and isopsoralen, meanwhile the weight content of the psoralen is above 80%, and the yield of the extract is above 10%. The extract can remarkably increase the bone mineral density of a patient suffering from osteoporosis and promote the effects of normal skeletal development and calcification.

Description

technical field [0001] The present invention relates to the field of traditional Chinese medicine, in particular, the present invention relates to the extract of fresh or dried Chinese herbal medicine Psoralen psoraleae and its preparation method and the use of the extract as medicine. Background technique [0002] Psoralea colifolia Linn. is a mature fruit of the genus Psoralen in the leguminous family. It is warm in nature, pungent and bitter in taste, and has the effects of invigorating the kidney and yang, nourishing qi and relieving diarrhea. Modern pharmacological studies have proved that psoraleae has a variety of pharmacological activities, such as anticancer activity, estrogen-like effect, improving the function of the immune system, promoting bone regeneration and reconstruction, and antibacterial. Among them, psoralen extract has a long history of being used in the prevention and treatment of osteoporosis, which is reflected in traditional Chinese medicine prescri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/487A61K31/05A61P19/10
CPCA61K31/05A61K36/487A61K2236/333A61K2236/55
Inventor 王昭日刘明川金志强杨胜杰林汉钦洪达
Owner SINPHAR TIAN LI PHARMA
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