256 results about "Bone mass density" patented technology

The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.

A dynamically molding orthotics device. The orthotics device consisting of a pre shaped counter frame containing an envelope within which a non-catalytic dynamic molding compound is sealed to interface between the pre-molded counter frame and the anatomy of the user. The counter frame of the pre molded shapes consist of irrigating canals, volume and pressure regulating pockets and relief areas for the purpose of (perpetually) dispersing and uniformly molding the compound to functionally dynamically and comfortably support and protect normal and amputated extremities and articulations of humans and animals. The molding compound is managed continuously by the pressures exerted between the continuously variable anatomical shapes of each extremity and articulation, flesh textures and bone densities, the pre molded counter frame shapes, and, the respective biomechanical dynamics of the whole body anatomy in each physical activity. These three elements combine to precisely circulate the molding compound to emphasize biomechanically sound support and comfort.

A woven retention device for interfacing with a bone surface includes interwoven filaments forming a tubular lattice with protuberances distributed on interior and exterior surfaces of the lattice at a predetermined spatial relationship. The protuberances are formed by intersecting interwoven filaments. The retention device receives and surrounds a fastener. In a first, relaxed state, the retention device has multiple combinations of filament cross-section geometries at the intersection points, and the multiple combinations of filament cross-section geometries form multiple protuberance thicknesses. In a second state when surrounding at least a portion of the fastener, the retention device distributes pressure from the fastener to multiple points of contact on the exterior surface of the retention device such that a spatial relationship of the protuberances changes as a function of bone density of the bone surface and as a function of an interfacing surface shape of the fastener.

The invention relates to health food for enhancing human immunity and increasing bone mineral density and a preparation method thereof; the health food of the invention comprises the following components: hyaluronic acid, glucosamine, collagen, kudzu root extracts, chondroitin sulfate, vitamins, calcium, etc; because of the embedding processing of hyaluronic acid, the defect of property change of hyaluronic acid due to moisture absorption and influence of environmental factors is overcome; the health food prepared by the organic combination of the embedded hyaluronic acid with glucosamine, collagen, plant extracts, vitamins, mineral matter and the like has functions and effects which can supplement each other, has the effects of lubricating joints, increasing bone mineral density, and enhancing bone strength during long-term administration, and also has the functions of delaying aging, removing freckles and beautifying faces, and the like; the health food of the invention can be prepared into powder, granules, tablets, capsules, is convenient for carrying and taking, has stable and lasting efficacy, has no side effects, and is an ideal health food of patients with hypoimmunity and osteoporosis.

In an embodiment of the invention, a method of measuring bone density is provided comprising: irradiating a volume to be analyzed; for x-rays emerging from the irradiated volume, detecting at least two of transmitted x-rays, forward scattered x-rays and backward scattered x-rays; and analyzing at least two of the transmitted x-rays, the forward scattered x-rays, or the backward scattered x-rays to determine a density by determining at least one of a ratio of the forward scattered x-rays to the backward scattered x-rays, a ratio of the forward scattered x-rays to the transmitted x-rays, or the product of the ratio of the forward scattered x-rays to the backward scattered x-rays and the ratio of the forward scattered x-rays to the transmitted x-rays.

The present invention relates to methods for prevention and / or treatment of metabolic disorders, post-menopausal obesity and conditions associated with high fat diet consumption including, obesity, body weight gain, fat mass formation, bone mineral content reduction, white adipose tissue weight gain, increased cholesterol levels, increased leptin levels, insulin resistance, type II diabetes, increased blood glucose levels, inflammatory diseases, cardiovascular diseases, fatty liver condition (accumulation of fat in the liver), decreased uncoupling protein-1 (UCP-1) levels and increased lipogenesis.

The present invention relates to teriparatide peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of bone density. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and / or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one glutathione; and at least one teriparatide peptide that is non-covalently bound to the corona.

The invention belongs to the field of sports research, in particular to a scientific fitness guidance system. The system realizes the collection on the basic information of human bodies, test on comprehensive sports ability and comprehensive analysis and evaluation on conditions of body functions. The system comprises a total control analytic host machine which is respectively connected with a body composition tester, a balance capacity tester, a bone mineral density tester, a flexibility tester, a physical strength tester, a maximal oxygen uptake tester and a reaction time tester through a local area network; the contribution of the scientific fitness guidance system to the prior art is to simply and rapidly provide comprehensive human body experiment test data for establishing a test program and method of sports function of adults and an evaluation method of comprehensive sports ability and constructing a scientific sports fitness evaluation and guidance system of Chinese citizens; the scientific fitness guide system realizes one-time test on the comprehensive data of human bodies and can rapidly and accurately carry out the comprehensive analysis and evaluation on physical conditions by setting threshold values to finish the formulation of a personalized sports fitness guidance scheme.

The invention discloses a method for designing and manufacturing an individual 3D printed implant. According to the method, the pore diameter of a porous net rack body is evenly divided into n1 grades, the porosity is evenly divided into n2 grades, the thickness is evenly divided into n3 grades, the elasticity modulus corresponding to n1*n2*n3 porous net rack bodies is divided into n4 grades, and densities of n4 bone substances are accorded; premaxillary bone quantitative CT photo-shooting is carried out on a patient, an average bone elasticity modulus E is calculated by utilizing three-dimensional reconstruction software and an empirical formula, and the thickest porous net rack body is selected from implants close to the range of the elasticity modulus; the implant is subjected to 3D printing, and the head part and the body part are integrally molded. The pore diameter, porosity and thickness of the porous net rack bodies are arranged in different grades, so that different sizes of elasticity modulus for the implants can be achieved, and the implant is suitable for people with different bone densities.

A woven retention device for interfacing with a bone surface is provided that includes a sleeve body that can surround a fastener, a proximal end for receiving the fastener, and a distal end. The sleeve body includes interwoven monofilaments of different diameters forming a substantially tubular lattice with protuberances distributed on interior and exterior surfaces of the lattice at a predetermined spatial relationship. In a first state, the sleeve body has a plurality of combinations of filament cross-section geometries at the intersection points, forming a plurality of protuberance thicknesses as measured in a radial direction of the sleeve body. In a second state when a fastener is inserted into the tubular lattice, pressure from the fastener is transmitted to the tubular lattice such that the spatial relationship of the protuberances changes according to a function of bone density and an interfacing surface shape of the fastener.

An x-ray densitometry system provides computer assistance to the operator in identifying possible sources of scanning or analysis error through computer review of the acquired data, operator input, and the ultimate diagnostic outputs.

An apparatus, method, and computer program product for calibrating a CT scan without the use of an external calibration phantom, to enable quantitative assessment of internal body tissues and organs and additionally for any application that would benefit from a calibration of the scan attenuation data, such as viewing CT images in a consistent fashion. Embodiments are described with applications to quantitative assessment of bone density in the spine and hip, mineral content in blood vessels, hepatic-fat content in the liver, and gray-to-white matter ratio in the brain. The primary advantages of the method are that it does not require the use of an external calibration phantom, it is robust across different CT machines and scanner settings, and it is also highly precise, lending itself to a high degree of automation.

The invention discloses tryptophan hydroxylase-1 inhibitor ursolic acid derivatives as well as a preparation method and application thereof and belongs to the technical field of the biological medicine. Proven by experiments, some ursolic acid derivatives are capable of specifically inhibiting the activity of Tph-1 without affecting that of Tph-2, and meanwhile, the bone mineral density data of vertebra also indicate that the bone mineral density of the vertebras of rats is obviously increased, and obviously, the ursolic acid derivatives are capable of effectively preventing osteoporosis and can be widely applied to preparing medicines for treating the osteoporosis.

The invention relates to a bone mineral density increase health capsule and a preparation method thereof. The capsule is composed of a capsule body and a content closed in the capsule body. The content is characterized in that the content comprises 15-30wt% of calcium carbonate, 8-20wt% of chondroitin sulfate, 10-25wt% of D-glucosamine hydrochloride, 0.02-0.2wt% of vitamin K1, 10-20wt% of a collagen polypeptide, 5-15wt% of momordica saponin, 5-15wt% of soybean isoflavone, 5-20wt% of sheep bone marrow peptide powder, 0.1-0.5wt% of vitamin D3 and 0.5-1wt% of an auxiliary material magnesium stearate; and the preparation method comprises the following steps: uniformly stirring the content, sending the uniformly stirred content to a capsule filling machine for filling the content to capsule shells, polishing, choosing, and packaging to obtain the bone mineral density increase health capsule. The health capsule has the advantages of synergistic effect of the above components, common improvement of the absorption of calcium by human bodies, bone mineral density increase, safety, reliability, obvious effect, and carrying and administrating convenience. The preparation method of the health capsule has the advantages of reasonable technology and strong operability.

The invention provides a composition with effects of protecting joints and increasing bone mineral density. The composition is prepared from the following components in parts by weight: 250-400 parts of calcium citrate malate, 150-300 parts of N-Sulfo-glucosamine potassium salt, 100-200 parts of chondroitin sulfate, 50-150 parts of bone collagen peptide powder, and 10-50 parts of casein phosphopeptides. According to the composition provided by the invention, the active ingredients achieve the synergistic effect, the bioavailability is high, and the composition can be used for increasing the bone mineral density and restoring the bone functions. Through a preparation method provided by the invention, the composition can be prepared into a compound preparation, the curative effects are definite, the quality is controllable, no toxic or side effect exists, and the composition is suitable for large-scale popularization and application.

The invention provides a composition for increasing the bone mineral density. The composition mainly comprises the following raw materials in parts by weight: 180-540 percent of calcium carbonate, 23-69 percent of D-glucosamine hydrochloride and 15-45 percent of collagen. The invention also provides a preparation method of the composition. The raw materials adopted by the composition for increasing the bone mineral density have no toxic and side effects, health and safety, has the effects of promoting calcium absorption and relieving osteoporosis and can safely and effectively supplement calcium of the human body and ensure that the calcium level is improved so as to prevent fractures and bone loss and has improvement effect on bone formation. Moreover, the invention adopts scientific andreasonable production process and better retains active constituents in various raw materials.

A probe device is for performing a bone density measurement is disclosed. The device comprises at least one ultrasound source for providing ultrasonic pulses; a plurality of ultrasound detectors for measuring the differences in arrival times of said ultrasonic pulses; at least one dedicated data processing element adapted for determining differences in arrival times of ultrasonic pulses; means for transferring data from said at least one measurement transducer to said at least one dedicated data processing element; and communication means adapted to transmit data from said dedicated data processing element to a non-dedicated computing means. Unlike systems known in the art, the measurements of the times of arrival of the ultrasonic pulses are performed within the probe itself, obviating the need for a dedicated computer system or measurement card.

The invention discloses a composition capable of improving joints and increasing bone mineral density and a preparation method of the composition. A Chinese herbal medicine extract which is refined from Chinese dwarf cherry by a modern extraction technology is scientifically compounded with other raw materials capable of increasing the bone mineral density, thus calcium absorption is effectively promoted from a plurality of aspects through comprehensive scientific combination and synergistic effect; cartilago articularis is repaired and rebuilt; synovial fluid is promoted to produce, synthesis of collagen in cartilago articularis matrix is promoted; further degeneration of cartilage is prevented; the osteoclast effect is indirectly weakened; re-absorption of bone is inhibited; the bone calcium content is increased; and the biomechanical property of the bone is improved, so that the composition has a good effect of increasing the bone mineral density. The integration and the biological stability of the composition can be further extracted by a microwave drying technology in the preparation method; the oxidation resistance of a grape seed extract in the raw material is improved; high adsorption and embedding effects of a dietary fiber and the antifungal properties of a Chinese herbal medicine extract are improved; and finally the composition which is efficient, safe, nutrient and stable, and has the function of increasing the bone mineral density is prepared.

The invention relates to a customized dental implant, and a preparation method thereof. The preparation method comprises following steps: 1, it is determined whether an autogenous extracted tooth dental crown is prepared; 2, an oral cavity optical digital impression is obtained; 3, a routine post-core root canal tooth is prepared; 4, if the bone mineral density data detected in step 1 is relatively high, and an extracted tooth is preserved, an integrated post-core and the autogenous extracted tooth dental crown are prepared, and a post-core three dimensional design matching the autogenous extracted tooth dental crown is formed; 5, if the bone mineral density data detected in step 1 is relatively high, and the extracted tooth preservation is qualified, an integrated post-core provided witha dental crown is prepared; 6, numerically controlled machining is adopted to prepare the customized integrated post-core; and 7, the prepared integrated post-core, or the integrated post-core and theautogenous extracted tooth dental crown are implanted into a prepared root canal using a binder. The preparation method is capable of realizing effective utilization of autogenous extracted teeth, and improving tooth implantation experience greatly.

The present invention relates to a nutritional composition for infants and / or toddlers comprising a lipid component which has a lipid globules coated with phospholipids. The composition is used for increasing bone mineral content, bone mineral density, preventing osteoporosis, and / or preventing ostopenia.

The invention provides a method for extracting artemisinin. The artemisinin is prepared through the method of supercritical fluid extraction and the method of microwave-assisted extraction, and the content of the artemisinin is greatly improved. The invention further provides the application of the artemisinin in preparing medicines for inhibiting proliferation of rat adrenal gland pheochromocytoma cell PC-12 and the application of the artemisnin in preparing medicines for increasing bone mineral density.

The invention relates to composition with effects of increasing bone mineral density, preventing inflammation and easing pain and a preparation method thereof. The composition with the effects of increasing bone mineral density, preventing inflammation and easing pain is prepared from the following bulk pharmaceutical chemicals ingredients of chondroitin sulfate, glucosamine hydrochloride, calcium carbonate, sodium hyaluronate, dimethyl sulfone and radix puerariae extract. The invention further relates to a film-coated tablet prepared from the composition and a preparation method of the film-coated tablet. The composition has a better curing effect of increasing bone mineral density, and all ingredients have a synergistic effect, can easily improve calcium absorption and can well increase bone mineral density; animal function experiments prove that the composition can obviously improve the thighbone weight, the bone calcium content, the thighbone middle point density and the thighbone telecentric end bone mineral density of a rat.

The invention provides an extracting method of seabuckthorn flavone which is prepared by adopting supercritical extraction and microwave extraction, so that content is greatly improved. The invention further provides application of the seabuckthorn flavone in preparation of a drug for restraining cell proliferation of C57BL / 6 mouse fibrosarcoma cells S180 and application of the seabuckthorn flavone in preparation of a drug for increasing bone density.

The invention discloses a new application of statin compound as topical medicine for preventing and curing osteoporotic fracture and enhancing bone plant strength in osteoporotic bone, particularly, discloses a topical statin composite for bone. The topical statin composite can increase bone mass, improve bone density, improve bone tissue microstructure and enhance bone mechanical property, thereby being used for preventing and curing osteoporotic fracture and enhancing the bone plant strength in osteoporotic bone.

The invention discloses a high-accuracy non-cross-infection wet type instrument for bone mineral density ultrasonic imaging, which comprises an ultrasonic energy converter, a limiter, an analogue switch, a filter, a numerical control gain amplifier, an analog-digital converter, a memorizer, a digital signal processor, a microprocessor, a signal source, a driver, a power level, a stepping motor, an X-Y two-dimension scanning module, a vacuum degassing water generator, a man-machine interaction device, a power supply device and a concave water tank for holding an ankle part to be detected. The instrument is used for measuring the digital ultrasonic quantitative parameters (QUS, Quantitative Ultrasound) of calcaneus, including BUA (Broadband Ultrasound Attenuation) and SOS (Speed of Sound), can measure real thickness of the calcaneus, eliminate influence of soft tissues on SOS, and provide degassed water for wet type measurement so as to provide high-accuracy bone mineral density value; by using a thin sock which is10 micrometers thick and made of silica gel and the like, cross infection can be eradicated; and the digitalized image of the calcaneus can be obtained by X-Y two-dimension scanning, and the imaging area of the calcaneus is 60*60 mm.

The invention relates to a computer aided detection and remote consultation system of bone mineral density. A bone mineral density computed tomography (CT) measuring method can selectively measure the cancellous bone density and is a blank in telemedicine. The system comprises a terminal ordering system, a terminal preprocessing system, a cloud computing processing center and a hospital backstage service management system. The terminal ordering system comprises a patient ordering module, wherein the patient ordering module is connected with a doctor calling module and a calling terminal. The terminal preprocessing module comprises a CT shooting device, a medical image processing system, a data remote transmission system and a terminal printing system. The cloud computing processing center comprises an image sorting, encrypting and decrypting processing module, a computer aided detection system and an expert outpatient service system. The hospital backstage service management system comprises an inquiring or storing case of illness image data bank and a diagnosis work station. The computer aided detection and remote consultation system of the bone mineral density can aim at the bone mineral density CT measurement to carry out consultation of doctors in different places, filter noise when the teletransmission is carried out on primary information, and break geographic restrictions. The patient can get more authoritative treatment.

The invention discloses a composition for increasing bone mineral density and a preparation method of the composition. Chinese dwarf cherry, a Chinese herbal medicine extract refined by a modern extraction technology and other raw materials with the function of increasing the bone mineral density are scientifically compounded, are scientifically combined in an omnibearing manner, and work together, so as to achieve the effects of effectively promoting absorption of calcium from a plurality of aspects, restoring and rebuilding cartilago articularis, creating synovial fluid, and promoting collagen synthesis in the cartilago articularis, preventing cartilage from further degenerating, indirectly reducing osteoclast action, inhibiting re-absorption of bones, increasing bone calcium content and improving the mechanical property of the bone, so that the product has a good effect of increasing the bone mineral density. The integrating property and the biological stability of the composition can be further improved by a microwave drying technology in the preparation method. Due to the oxidation resistance of a grape pip extract in the raw materials, high adsorption and embedding effects of modified dietary fiber, and antifungal properties of the Chinese herbal medicine extract, the efficient, safe, nutrient and stable composition with the function of increasing the bone mineral density is finally prepared.