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Processing method of fructus psoraleae medicinal material, fructus psoraleae extract and use of fructus psoraleae extract

A technology of psoralen extract and psoralen, which is applied in the processing of psoralen medicinal materials, and the field of psoralen extract obtained can solve the problems of psoralen hepatotoxicity and damage

Inactive Publication Date: 2020-08-28
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0014] At present, the psoralen produced by the known method has a relatively large hepatotoxicity damage hazard, and many Chinese patent medicines containing psoralen have certain side effects

Method used

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  • Processing method of fructus psoraleae medicinal material, fructus psoraleae extract and use of fructus psoraleae extract
  • Processing method of fructus psoraleae medicinal material, fructus psoraleae extract and use of fructus psoraleae extract
  • Processing method of fructus psoraleae medicinal material, fructus psoraleae extract and use of fructus psoraleae extract

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0053] Experimental Example 1: Research on the components of psoraleae that cause hepatotoxic damage

[0054] In the previous study, coumarin glycosides (psoralen, isopsoralen), coumarin (psoralen, isopsoralen, psoralen), flavonoids (psoralen), and flavonoids (psoralen) were isolated from psoralen. Compounds such as bone lip isoflavone, isopsoralen chalcone, psoralen dihydroflavone, corylifol A, neopsoralen isoflavone), monoterpene phenol (bakuchiol), etc.

[0055] Estrogen-like activity studies on the above-mentioned related compounds [1] , the results showed that: psoralen and isopsoralen exert estrogen-like effects by activating ERα; Compounds such as lipophenol exert estrogen-like effects by activating ERα and ERβ. The binding rate of psoralen and isopsoralen to ERα is much higher than that of ERβ, while bakuchiol mainly acts on ERβ.

[0056] research shows [2]-[3] Long-term use of estrogen in large quantities can cause animal liver damage, such as hepatomegaly, live...

experiment example 2

[0062] Experimental Example 2 Study on liver toxicity of different medicinal parts of psoraleae medicinal material after water extraction

[0063] In order to clarify the medicinal parts of psoraleae that caused liver toxicity after water extraction, further studies were carried out on the psoralen raw drug group (psoralen medicinal material), psoralen water extract group, and psoralen dregs group after water extraction. liver toxicity studies.

[0064] Preparation of psoralen water extract and psoralen dregs: add 8 times the amount of psoralen medicinal material to heat reflux extraction at 100°C, extract twice, each time for 1.5 hours, filter to obtain the water extract, and concentrate under reduced pressure It becomes a thick paste, which is the water extract; the dried dregs obtained after filtration are the dregs of psoraleae after water extraction.

[0065] Determination of psoralen, isopsoralen, psoralen, isopsoralen, The content of psoralen B and bakuchiol (assay ...

experiment example 3

[0072] Experimental Example 3 Hepatotoxicity and drug efficacy research of the processed product obtained by the processing method of the present invention

[0073] 3.1. Liver toxicity study:

[0074] Rat hepatotoxicity studies were carried out with psoraleae original drug and processed products obtained by the processing method of the present invention. For the processing method of the present invention, refer to the preparation of psoralen dregs in Experimental Example 2. The results are shown in Table 2-4.

[0075] Table 2 Effect of continuous gavage for 1 month on liver weight and liver coefficient in rats

[0076]

[0077] Note: Compared with the control group, 1) P2) P3)P<0.001;

[0078] Compared with the same dose crude drug group, a) Pb) Pc) P<0.001.

[0079] Table 3 Effect of continuous gavage for 1 month on rat liver MDA

[0080]

[0081] Note: Compared with the control group, 1) P2) P3) P<0.001;

[0082] Compared with the same dose crude drug group, ...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and relates to a processing method of a fructus psoraleae medicinal material, which specifically comprises: extractingthe fructus psoraleae medicinal material by adding water, and collecting dregs after removing water extract, so that the fructus psoraleae extract capable of being used as the drug is obtained. In addition, the invention also relates to a fructus psoraleae extract prepared by the processing method and medical use of the extract. According to the processing method disclosed by the invention, most of water-soluble components, such as psoralenoside and isopsoralenoside, in the fructus psoraleae are removed; and the hepatotoxic injury of the fructus psoraleae extract is effectively reduced.

Description

[0001] The present invention is the application number 201510767141.0, the priority date is November 11, 2014, the application date is November 11, 2015, and the invention name is "a processing method of psoraleae medicinal material, psoralen extract and medicine A divisional application of the "composition" application. technical field [0002] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a processing method of psoraleae medicinal material to reduce the liver toxicity damage of the medicinal material, and also relates to the obtained psoralen extract and its medical application. Background technique [0003] Psoralea corylifolia L. is the dried and mature fruit of Psoralea corylifolia L., a leguminous plant, also known as Poguzhi, Poguzhi, and Huyuzi. Psoraleae is 60-150cm high, the leaves are single, 7-8mm long; the petiole is 2-4.5cm long, the leaves are broadly ovate, the inflorescences are axillary, with 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/487A61P35/00A61P37/04A61P39/02A61P31/04A61P31/10A61P19/10A61P17/00A61P15/00A61P13/00A61P9/08A61P7/00A61P5/30A61P1/12A61P1/14A61P29/00A61P13/12A61P11/06A61P9/00A61P43/00A61P7/04A61P17/16A61K131/00
Inventor 高秀梅周昆王跃飞刘二伟樊官伟张伯礼
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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