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Processing method of fructus psoraleae medicinal materials, fructus psoraleae extract and pharmaceutical composition

A technology of psoralen extract and psoralen, which is applied in the processing of psoralen medicinal materials, the obtained psoralen extract and pharmaceutical composition, can solve the problems of psoralen liver toxicity and damage, and achieve Reduce hepatotoxicity damage, treat low back and knee pain, and enhance immunity

Inactive Publication Date: 2016-01-13
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] At present, the psoralen produced by the known method has a relatively large hepatotoxicity damage hazard, and many Chinese patent medicines containing psoralen have certain side effects

Method used

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  • Processing method of fructus psoraleae medicinal materials, fructus psoraleae extract and pharmaceutical composition
  • Processing method of fructus psoraleae medicinal materials, fructus psoraleae extract and pharmaceutical composition
  • Processing method of fructus psoraleae medicinal materials, fructus psoraleae extract and pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0052] Experimental Example 1: Research on the components of psoraleae that cause hepatotoxic damage

[0053] In the previous study, coumarin glycosides (psoralen, isopsoralen), coumarin (psoralen, isopsoralen, psoralen), flavonoids (psoralen), and flavonoids (psoralen) were isolated from psoralen. Compounds such as bone lip isoflavone, isopsoralen chalcone, psoralen dihydroflavone, corylifol A, neopsoralen isoflavone), monoterpene phenol (bakuchiol), etc.

[0054] Estrogen-like activity studies on the above-mentioned related compounds [1] , the results showed that: psoralen and isopsoralen exert estrogen-like effects by activating ERα; Compounds such as phenol exert estrogen-like effects by activating ERα and ERβ. The binding rate of psoralen and isopsoralen to ERα is much higher than that of ERβ, while bakuchiol mainly acts on ERβ.

[0055] research shows [2]-[3] Long-term use of estrogen in large quantities can cause animal liver damage, such as hepatomegaly, liver ce...

experiment example 2

[0061] Experimental Example 2 Study on liver toxicity of different medicinal parts of psoraleae medicinal material after water extraction

[0062] In order to clarify the medicinal parts of psoraleae that caused liver toxicity after water extraction, further studies were carried out on the psoralen raw drug group (psoralen medicinal material), psoralen water extract group, and psoralen dregs group after water extraction. liver toxicity studies.

[0063] Preparation of psoralen water extract and psoralen dregs: add 8 times the amount of psoralen medicinal material to heat reflux extraction at 100°C, extract twice, each time for 1.5 hours, filter to obtain the water extract, and concentrate under reduced pressure It becomes a thick paste, which is the water extract; the dried dregs obtained after filtration are the dregs of psoraleae after water extraction.

[0064] Determination of psoralen, isopsoralen, psoralen, isopsoralen, The content of psoralen B and bakuchiol (assay ...

experiment example 3

[0071] Experimental Example 3 Hepatotoxicity and drug efficacy research of the processed product obtained by the processing method of the present invention

[0072] 3.1. Liver toxicity study:

[0073] Rat hepatotoxicity studies were carried out with psoraleae original drug and processed products obtained by the processing method of the present invention. For the processing method of the present invention, refer to the preparation of psoralen dregs in Experimental Example 2. The results are shown in Table 2-4.

[0074] Table 2 Effect of continuous gavage for 1 month on liver weight and liver coefficient in rats

[0075]

[0076] Note: Compared with the control group, 1) P2) P3) P<0.001;

[0077] Compared with the same dose crude drug group, a) Pb) Pc) P<0.001.

[0078] Table 3 Effect of continuous gavage for 1 month on rat liver MDA

[0079]

[0080] Note: Compared with the control group, 1) P2) P3) P<0.001;

[0081] Compared with the same dose crude drug group, a...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and relates to a processing method of fructus psoraleae medicinal materials. The method particularly comprises the steps that fructus psoraleae medicinal materials are extracted through water, a water extract solution is discarded, dregs of a decoction are collected, and fructus psoraleae extract which can be used as medicine is obtained. In addition, the invention further relates to the fructus psoraleae extract prepared through the processing method and a pharmaceutical composition containing the fructus psoraleae extract. By means of the processing method, most of water-soluble components such as psoralenoside and isopsoralenoside are removed, and hepatotoxicity damage of the fructus psoraleae extract is effectively reduced.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a method for processing psoraleae medicinal material to reduce the liver toxicity damage of the medicinal material, and also relates to the obtained psoraleae extract and pharmaceutical composition. Background technique [0002] Psoralea corylifolia (Psoralea corylifolia L.), is the dried and mature fruit of Psoralea corylifolia L. of the leguminous plant, also known as broken paper, poguzhi, and chives. Psoraleae is 60-150cm high, the leaves are single, 7-8mm long; the petiole is 2-4.5cm long, the leaves are broadly ovate, the inflorescences are axillary, with 10-30 flowers, the corolla is yellow or blue, and the petals are obvious Stem, flag petals obovate, pods ovate, flower and fruit period from July to October. [0003] Psoraleae has the effects of warming the kidney and supporting yang, relieving qi and relieving asthma, warming the sple...

Claims

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Application Information

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IPC IPC(8): A61K36/487A61P35/00A61P37/04A61P39/02A61P31/04A61P19/10A61P17/00A61P15/00A61P13/00A61P9/08A61P7/00A61P5/30A61P1/12
Inventor 高秀梅周昆王跃飞刘二伟樊官伟张伯礼
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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