The invention discloses an R6-FAD and BP-MCS-based fuzzy random reliability evaluation method for a pipeline with crack defects, and the method combines a BP neural network and Monte Carlo simulation based on a failure evaluation diagram of an R6 specification, and is applied to the fuzzy random reliability evaluation of the pipeline with the crack defects. The method mainly comprises the following steps: step 1, inputting probability distribution types and parameters of actual working condition load, crack defect size and material performance and maximum simulation times N, and establishing a fuzzy limit state equation; 2, determining basic parameters, and constructing an initialized BP neural network; 3, training a neural network to ensure that the neural network can better approach a fuzzy limit state equation; and 4, random sampling being carried out, and a Monte Carlo principle being used to calculate a failure probability and a reliability index. According to the method, the fuzzy reliability randomization process can be simplified, and a numerical solution with relatively high simulation precision can be obtained; meanwhile, the fuzzy random coupling uncertainty of the structure is considered, the method is better in line with engineering practice, and the method has guiding significance for safety assessment of the structure.