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Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique

A vascular and rapid technology is applied in the field of preparation of instant stents, which can solve the problems of lack of clinical application, damage to the vascular intima, unable to support the function, etc., and achieve the effect of simple vascular anastomosis method, improved success rate, and smooth surface.

Inactive Publication Date: 2002-01-02
GENERAL HOSPITAL OF PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] People have successively invented a variety of vascular anastomosis methods, such as: thermal coagulation vascular anastomosis method (laser welding method, bipolar electrocoagulation anastomosis method, etc.), cannula or collar anastomosis method and instrument anastomosis method, etc., because these methods are all It has its own shortcomings, so it has not been clinically applied
The stents currently used for vascular anastomosis are mainly ester stents, sugar stents, and polyethylene glycol stents. All kinds of stents have shortcomings, such as: the strength of the stents decreases significantly after being exposed to water, and they cannot be used in the whole process of anastomosis. Supporting effect, potential cytotoxicity, damage to vascular intima, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Gelatin is configured into a 20% (mass ratio) solution at 90°C, and the solution can solidify at 20°C.

[0015] 2. Heat the solution to 80°C, add 10% disodium hydrogen phosphate under rapid stirring, stir for 10 minutes and keep warm for later use

[0016] 3. Under the external environment of 10°C, extrude or draw the melted compound into a rod-shaped or hollow tube support with a suitable thickness using a suitable die, and trim it to a length of 5-20nm

[0017] 4. The scaffold material was pre-frozen at -40°C for 12 hours, and then freeze-dried in a freeze dryer for 24 hours

[0018] 5. Calibrate the size and quality of the bracket, cobalt-60 sterilized package, and store at 4°C for later use

[0019] 6. During the operation, take a stent with a suitable diameter, put it into the blood vessel to be anastomotic, and align the broken ends

[0020] 7. Use medical adhesive to bond the broken end outside the blood vessel, open the blood vessel clamp, the stent will qu...

Embodiment 2

[0022] 1. Gelatin is configured at 90° C. to a solution of 20% mass ratio), and the solution can solidify at 20° C.

[0023] 2. Heat the solution, add 20% mass of disodium hydrogen phosphate under rapid stirring, stir for 10 minutes and keep warm for later use

[0024] 3. Under the external environment of 10°C, extrude or draw the melted compound into a rod-shaped or hollow tube bracket of suitable thickness, and trim it to a length of 5-20 mm

[0025] 4. The scaffold material was pre-frozen at -20°C for 12 hours, and then freeze-dried on a freeze dryer for 30 hours

[0026] 5. Calibrate the size and quality of the bracket, cobalt-60 sterilized package, 40 to save for later use

[0027] 6. During the operation, take a stent with a suitable diameter, put it into the blood vessel to be anastomotic, and align the broken ends

[0028] 7. Use medical adhesive to bond the broken end outside the blood vessel, open the blood vessel clamp, the stent will quickly dissolve in the blood...

Embodiment 3

[0030] 1. Gelatin is configured into a 20% (mass ratio) solution at 90°C, and the solution can solidify at 20°C.

[0031] 2. Heat the solution, add 20% mass of sodium chloride under rapid stirring, stir for 10 minutes and keep warm for later use

[0032] 3. Extrude or draw the melted compound into a rod-shaped or hollow tube bracket of appropriate thickness at 0°C, and trim it to a length of 5-20 mm

[0033] 4. The scaffold material was pre-frozen at -40°C for 24 hours, and then freeze-dried on a freeze dryer for 30 hours

[0034] 5. Calibrate the size and quality of the bracket, cobalt-60 sterilized package, and store at 4°C for later use

[0035] 6. During the operation, take a stent with a suitable diameter, put it into the blood vessel to be anastomotic, and align the broken ends

[0036] 7. Use medical adhesive to bond the broken end outside the blood vessel, open the blood vessel clamp, the stent will quickly dissolve in the blood, and the anastomotic port will be drai...

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PUM

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Abstract

A preparation method of the invented quick-soluble scaffold for anastomosis of blood vessel includes the following steps: firstly, preparing double-distilled water solution by using dissolvable polymer, heating the above-mentioned solution, quickly stirring and adding physiological salt powder to form ropy compound, using mould to extrude or draw the said compound to make it into claviform or hollow tube which is identical to vassel of human body in diameter so as to obtain the invented soluble scaffold material. This blood vessel scaffold possesses micrometer level porosity in structure, after it is compounded with physiological salt crystal, its mechanical strength is increased, in the course of application, it features proper dissolving time, smooth surface, good elasticity and does not damage endangium, and it is non-toxic, and has no residual. It is quick in anastomosis speed, simple and easy to implement.

Description

Technical field: [0001] The invention relates to a preparation method of an instant stent used in a minimally invasive rapid blood vessel anastomosis technique, which aims at improving the quality of blood vessel anastomosis, simplifying the operation and increasing the speed of blood vessel anastomosis, and belongs to the technical field of biomaterials. Background technique: [0002] Vascular anastomosis technique is the basic technique of surgery. Its emergence and development have directly promoted the development of the whole surgery. The traditional needle-thread vascular suture technique is still the most widely used vascular anastomosis technique. After a long period of strict training, a higher The patency rate of vascular anastomosis, but its shortcomings cannot be ignored: doctors must undergo strict professional skills training to master this technique; the surgical conditions are high; the operation is complicated; difficult; and time-consuming. Due to the parti...

Claims

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Application Information

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IPC IPC(8): A61B17/11A61L17/10
Inventor 梁向党范昱玮崔福斋张伯勋
Owner GENERAL HOSPITAL OF PLA
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