39 results about "Vessel dilator" patented technology

A vascular interventional device may be introduced over a guidewire into a vessel of the cardiovascular system of a patient. This device includes a hollow, flexible tube having a proximal end and a distal end that is adapted to selectively engage a target vessel of the cardiovascular system of the patient. This tube also includes a lumen that is continuous from the proximal to the distal end, and has an end hole in the distal end that is in fluid communication with the lumen. A plurality of side holes are provided near the distal end of the tube, each of which is in continuous fluid communication with the lumen. The device also includes a hollow vessel dilator that is adapted for insertion into and through the tube and over the guidewire. The dilator has an inside diameter that is slightly larger than the guidewire and an outside diameter that is slightly smaller than the diameter of the lumen of the tube. The distal end of the dilator is adapted to accommodate vascular entry over the guidewire, and the dilator is adapted to dilate the vessel to accept the tube. The device also includes a hub at the proximal end of the tube. The hub includes an end port through which a second interventional device having an outside diameter smaller than the diameter of the lumen may be introduced into the lumen of the tube. The hub also includes a side port through which a fluid agent may be injected for delivery through the lumen and out the end hole and side holes of the tube. A sealing mechanism is also provided in the hub to prevent air from entering the tube and blood and other fluids from leaking out of the tube through the hub. A pair of vascular interventional devices, at least one of which is constructed according to the invention, may be utilized to treat or study a cardiovascular condition, or to measure the blood pressure across a vascular segment.

A vascular interventional device may be introduced over a guidewire into a vessel of the cardiovascular system of a patient. This device includes a hollow, flexible tube having a proximal end and a distal end that is adapted to selectively engage a target vessel of the cardiovascular system of the patient. This tube also includes a lumen that is continuous from the proximal to the distal end, and has an end hole in the distal end that is in fluid communication with the lumen. The device also includes a hollow vessel dilator that is adapted for insertion into and through the tube and over the guidewire. The dilator has an inside diameter that is slightly larger than the guidewire and an outside diameter that is slightly smaller than the diameter of the lumen of the tube. The distal end of the dilator is adapted to accommodate vascular entry over the guidewire, and the dilator is adapted to dilate the vessel to accept the tube. The device also includes a hub at the proximal end of the tube. The hub includes an end port through which a second interventional device having an outside diameter smaller than the diameter of the lumen may be introduced into the lumen of the tube. The hub also includes a side port through which a fluid agent may be injected for delivery through the lumen and out the end hole of the tube. A sealing mechanism is also provided in the hub to prevent air from entering the tube and blood and other fluids from leaking out of the tube through the hub. A pair of vascular interventional devices, at least one of which is constructed according to the invention, may be utilized to treat or study a cardiovascular condition, or to measure the blood pressure across a vascular segment.

A telescoping dilator assembly is configured for percutaneous insertion of large diameter intravascular devices into a blood vessel while avoiding kinking of a guidewire and minimizing blood loss. The assembly includes a first smaller diameter dilator with an inner lumen that fits snugly over a guidewire. The smaller dilator may be tapered on both ends. A second larger diameter dilator is configured to slide over the first smaller dilator. A tear away sheath is configured to slide over the dilators and into a blood vessel. A tear away sheath plug is configured to form a seal at a proximal end of the sheath. When the dilators are removed from the blood vessel, an intravascular device may be passed through the sheath into the blood vessel.

A vascular suturing device is disclosed which includes an elongated tubular body defining opposed proximal and distal end portions and having a longitudinal axis extending therethrough, the body including an inner tubular member, an outer tubular member and a central tubular member disposed between the inner and outer tubular members. The inner tubular member and the central tubular member are mounted for movement relative to the outer tubular member about the longitudinal axis of the body for sequentially driving a pair of suture needles through the wall of a blood vessel to close an incision formed therein. A vascular dilator having a tapered distal tip portion is supported within the inner tubular member and is dimensioned to extend beyond the distal end of the inner tubular member for positioning the suturing device at the incision in the wall of the blood vessel. The dilator is configured to direct blood flow from the distal portion of the dilator to a location remote from the blood vessel for observation to confirm the location of the device.

The present invention relates to a dilator. The dilator includes a shaft, a lumen and a hub. The shaft has at least two stiffness sections with the stiffness sections becoming less rigid as they approach a distal end of the shaft. The varying stiffness sections allow the dilator to track along the guidewire through torturous vasculature so as the dilator is advanced and the stiffness is changed, the stiffer sheath can advance smoothly through a blood vessel. The dilator may also taper at the distal tip to stretch the initial skin puncture hole larger to accommodate the dilator shaft and ease the sheath tip insertion through to the vasculature. Or the shaft may taper from where it extends beyond the sheath distal tip to the distal end so that it can reach further distal in the vasculature. The dilator may also include an atraumatic tip for easier advancement of the dilator. The dilator distal end may also include one or more radiopaque markers and a shaped distal end.

The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one embodiment, the delivery of stem cells to the myocardium by intracoronary infusion is improved by administration of one or more vasodilators and / or vascular permeability enhancers prior to or at the time of cell therapy.

A vessel access and closure device places a running suture in the wall of a blood vessel using a rotating helical suture needle that carries the suture along a helical path passing through the vessel wall, then reverses rotation to release a suture anchor attached to the distal end of the suture. A loose helical coil of suture is left behind as the helical suture needle withdraws. The device is withdrawn and replaced with a vessel dilator and an introducer sheath that opens up a larger access opening into the blood vessel and creates a pathway that passes though the helical coil of suture for introducing an interventional device into the blood vessel. After the interventional procedure is completed, the interventional device and the introducer sheath are withdrawn and the running suture is tightened and secured with a suture lock to close the access opening into the vessel.

A vascular suturing device is disclosed which includes an elongated tubular body defining opposed proximal and distal end portions and having a longitudinal axis extending therethrough, the body including an inner tubular member, an outer tubular member and a central tubular member disposed between the inner and outer tubular members. The inner tubular member and the central tubular member are mounted for movement relative to the outer tubular member about the longitudinal axis of the body for sequentially driving a pair of suture needles through the wall of a blood vessel to close an incision formed therein. A vascular dilator having a tapered distal tip portion is slidably supported within the inner tubular member and is dimensioned to extend beyond the distal end of the inner tubular member for positioning the suturing device at the incision in the wall of the blood vessel. The dilator is configured to move axially between an extended position and a retracted position. A biasing element and a retaining pin are associated with a proximal end of the dilator. The biasing element is adapted and configured for urging the dilator in the retracted position and the retaining pin is position so as to secure the dilator in the extended position.

A vascular suturing device is disclosed which includes an elongated tubular body defining opposed proximal and distal end portions and having a longitudinal axis extending therethrough, the body including an inner tubular member, an outer tubular member and a central tubular member disposed between the inner and outer tubular members. The inner tubular member and the central tubular member are mounted for movement relative to the outer tubular member about the longitudinal axis of the body for sequentially driving a pair of suture needles through the wall of a blood vessel to close an incision formed therein. A vascular dilator having a tapered distal tip portion is slidably supported within the inner tubular member and is dimensioned to extend beyond the distal end of the inner tubular member for positioning the suturing device at the incision in the wall of the blood vessel. The dilator is configured to move axially between an extended position and a retracted position. A biasing element and a retaining pin are associated with a proximal end of the dilator. The biasing element is adapted and configured for urging the dilator in the retracted position and the retaining pin is position so as to secure the dilator in the extended position.

A vascular dilator for controlling blood flow in a blood vessel, includes an elongate body for inserting into a blood vessel and a generally tapered distal end portion and a proximal end portion, and a plurality of inflatable members positioned adjacent the distal end portion. The inflatable members are longitudinally spaced from one another by a predetermined distance.

Cerebral Catheter devices and methods for use are provided. The catheter devices provided may include an anti-thrombotic agent coating on the exterior surface. The catheter devices may include unique tip configurations to allow improved fluid delivery capabilities. Further, the catheter devices may also or alternatively include one or more sensor devices in communication with a controller that allow automatically adjusting the delivery of a therapeutic fluid, for example a vasodilator, in response to the condition sensed by the catheter device, such as increased pressure. Moreover, the catheter devices may also be used in conjunction with blood flow transducers to detect and timely prevent and treatment vasospasms or other conditions. Methods for preventing and treatment vasospasm, neoplasm, or other pathological conditions while prolonged using the catheter device are also provided.

Single needle vascular access systems, devices and methods for use in hemodialysis and apheresis procedures. A single needle vascular access device includes a body having an upper and lower passage with both in fluid communication with a vascular dilator. A cannulation needle is guided through the lower passage and vascular dilator to cannulate a graft or fistula. Following cannulation, the dilator is gently introduced into the vessel. The cannulation needle is removed, and a venous tube is introduced through the upper passageway through the vascular dilator and into the fistula or graft. Blood is then removed from the body through the vascular dilator side orifices and returned through the venous line. Depending on the clinical situation, the vascular dilator can be used with one or both needles of a conventional two needle system. In the later case, the vascular dilator may be connected to the dialysis tubes using conventional standard connectors.

Vascular dilator systems, kits, and methods allowing for sheathless introduction of a treatment device into a body vessel or body cavity are disclosed. A vascular dilator system can include a dilator assembly, including a tubular shaft and a deformable member, and optionally, the treatment device. The deformable member can include a non-biodegradable material and can have a diameter at a proximal end portion that is greater than a diameter at a distal end portion. The distal end portion of the deformable member can be coupled to an outer surface of the tubular shaft, at or near a shaft distal end portion. The proximal end portion of the deformable member can include a diameter configured to receive or stretch around a distal end portion of the treatment device. In use, the deformable member can provide a tapered bridge between the outer surface of the tubular shaft and an outer surface of the treatment device.

A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.

The present invention relates to a method of treating congestive heart failure (CHF) in a subject comprising administering a peptide derived from atrial natriuretic peptide (ANP) prohormone (eg vessel dilator; VSDL) or a mimetic thereof. In a particular application, the invention provides a method of treating the particular indication known as acute decompensated congestive heart failure (ADCHF). Devices for intravenous or subcutaneous infusion for use in the method of the invention are also disclosed.

A vascular dilator for controlling blood flow in a blood vessel, includes an elongate body for inserting into a blood vessel and a generally tapered distal end portion and a proximal end portion, and a plurality of inflatable members positioned adjacent the distal end portion. The inflatable members are longitudinally spaced from one another by a predetermined distance.

The invention relates to a medical instrument, in particular to a tool for a vessel dilator implanting operation.The tool comprises a handle and a push rod which is inserted into the handle and can axially move.A press plate is arranged at the rear end of the push rod, and the push rod is sleeved with a spiral jacket.The spiral jacket is formed by spirally winding a special-shaped monofilament.An upper clamping screw and a lower clamping screw are symmetrically arranged at the upper end and the lower end of the section of the the special-shaped monofilament.One end of the special-shaped monofilament is fixedly connected to the front end of the push rod, and the other end of the special-shaped monofilament is fixedly connected to the handle.The tool is simple in structure, convenient to operate and wide in application range.

The invention relates to a medical instrument, in particular to a push rod type vascular dilator implanting tool, comprising a slide rail and a push rod axially movable and insertable in the slide rail, the rear end of the push rod is provided with a gear-rack meshing axial pushing mechanism, a spiral ferrule sleeves the push rod and is made by spiraling a special-shaped single wire, and upper and lower ends of the section of the special-shaped single wire are symmetrically provided with an upper clamping spiral and a lower clamping spiral, one end of the special-shaped single wire is fixedly connected to the front end of the push rod, and the other end of the special-shaped single wire is fixedly connected to the slide rail. The push rod type vascular dilator implanting tool is simple in structure, convenient to perform and widely applicable.

The present invention relates to a method of treating congestive heart failure (CHF) in a subject comprising administering a peptide derived from atrial natriuretic peptide (ANP) prohormone (eg vessel dilator; VSDL) or a mimetic thereof. In a particular application, the invention provides a method of treating the particular indication known as acute decompensated congestive heart failure (ADCHF). Devices for intravenous or subcutaneous infusion for use in the method of the invention are also disclosed.

The invention relates to an anti-injury medical vessel dilator and simulation method of hemangiectasis. The anti-injury medical vessel dilator comprises a flexible catheter, an injector connector arranged at the inlet end of the flexible catheter and a conical part at the outlet end of the flexible catheter; the injector connector, the flexible catheter and the conical part are connected orderly,the conical part is a hollow conical pipe; diameter of the conical part is gradually enlarged from the free end of the conical part to the joint of the flexible catheter; multiple guide flow holes arearranged on the side wall of the conical part. The invention solves the technical problems that the hemangiectasis section applied to the operation process of autologous internal arteriovenous fistula plasty at present is poor in dilating effect, easy to cause blood vessel injury, and low in operation success rate. The vessel dilator provided by the invention can rapidly dilate operation vessel and not damage blood vessels during the operation process.

The invention belongs to the technical field of medical instruments, and particularly relates to a puncture needle suite assembly and a using method thereof.The puncture needle suite assembly comprises a puncture needle suite assembly body and a hose, the puncture needle suite assembly body is composed of a puncture sheath, a blood vessel dilator, an obturator, a miniature guide wire and a puncture needle, and a third hollow pipe is fixedly installed at one end of the hose; a first hollow tube is fixedly installed on the inner wall of the top end of the puncture needle, the inner wall of the first hollow tube is detachably connected with a third hollow tube through a fixing structure, and a sealing structure is arranged at one end of the puncture needle. Compared with the prior art, the tail end of the puncture needle is prevented from being injected into a contrast agent, so that the phenomenon that the puncture needle moves is avoided, and the situation that blood cannot be seen after blood return is punctured is avoided, so that great convenience is brought to medical staff.

The invention relates to a medical instrument, in particular to a vascular dilator implanting tool with a locking mechanism, comprising a handle and a push rod inserted into the handle and that can axially move. The rear end of the push rod is provided with a press plate and sleeved with a spiral sleeve, the spiral sleeve is made by spiraling a deformed single wire, the upper and lower ends of the section of the deformed single wire are symmetrically provided with an upper clamping thread and a lower clamping thread, one end of the deformed single wire is fixedly connected to the front end of the push rod, and the other end of the deformed single wire is fixedly connected to the handle. This tool is simple in structure, convenient to operate and widely applicable.

Methods of producing a recombinant peptide, such as vessel dilator peptide (VSDL), are disclosed, including a particular method involving expressing a fusion polypeptide comprising concatemeric repeats of the peptide wherein the peptide is flanked by peptide cleavage sites, and cleaving the fusion polypeptide at the peptide cleavage sites with a cleaving agent(s) so as to release the peptide from the fusion polypeptide. Expression constructs and host cells for producing the fusion polypeptide and purification methods for the recombinant peptide are also disclosed.

The invention discloses a medical surgery implant device of a vessel dilator. The device comprises a shaft rod and a plurality of sleeve plates, wherein the shaft rod is sleeved with the sleeve plates, an operation end of the shaft rod is sleeved with a shaft sleeve, the end face, close to the sleeve plates, of the shaft sleeve is provided with at least one control rod along an axial direction ofthe shaft sleeve, the control rod is provided with a detachable rotation supporting rod, same side faces of the sleeve plates are provided with baffle rings, the outer diameters of the baffle rings are the same as those of the sleeve plates, and each sleeve plate comprises an inner plate and an outer plate arranged on the periphery of the corresponding inner plate. The invention aims for providingthe medical surgery implant device of the vessel dilator capable of being operated in surgeries and an operation method thereof.

The invention relates to a medical tool, in particular to a spiral clamping-type vessel dilator assembly. The spiral clamping-type vessel dilator assembly comprises a spiral vessel dilator body and a clamping tool for clamping the dilator body. The clamping tool comprises a handle and a pushing rod which is inserted into the handle and can move in the axial direction; a pressing plate is arranged at the back end of the pushing rod, the pushing rod is sleeved with spiral clamping sleeves, the spiral clamping sleeves are formed by spirally twisting special-shaped single wires, upper clamping spiral parts and lower clamping spiral parts are symmetrically arranged at the upper ends and the lower ends of the cross sections of the special-shaped single wires, one ends of the special-shaped single wires are fixedly connected to the front end of the pushing rod, and the other ends of the special-shaped single wires are fixedly connected to the handle. The tool is simple in structure, convenient to operate and wide in application range.

The invention relates to a medical instrument, in particular to a push rod type vascular dilator implanting tool, comprising a slide rail and a push rod axially movable and insertable in the slide rail, the rear end of the push rod is provided with a gear-rack meshing axial pushing mechanism, a spiral ferrule sleeves the push rod and is made by spiraling a special-shaped single wire, and upper and lower ends of the section of the special-shaped single wire are symmetrically provided with an upper clamping spiral and a lower clamping spiral, one end of the special-shaped single wire is fixedly connected to the front end of the push rod, and the other end of the special-shaped single wire is fixedly connected to the slide rail. The push rod type vascular dilator implanting tool is simple in structure, convenient to perform and widely applicable.