Watch type non-invasive light sound blood sugar monitoring instrument

Abstract

The invention relates to a watch-type non-trauma optical acoustic blood sugar monitor. A display screen, a control button, a controller, a cell and a measurement box are arranged in watch-type casing, an acoustic insulating layer, a sound absorption pad, a semiconductor laser tube, a Fourier lens, a light-transparent protection film and a hollow multi-ring array sensor are packaged in the measurement box to form a integrated coaxial confocal structure. The watch-type casing is equipped with a watchband to be wore on wrist of detector, an optical acoustic excitation source and an optical path lens system generate focused laser beam which passes through the hollow multi-ring array sensor and radiates to blood vessel of wrist to realize optical acoustic blood sugar detection of continuous A-type dynamic focusing scan and provide optical acoustic blood sugar results of multiple sites along wrist depth direction. The monitor has advantages of having small structure and simple operation, realizing real-time monitoring of optical acoustic blood sugar, having no trauma when detecting, having no need of blood supply and test paper, and avoiding cross infection and environmental influence.

Description

technical field [0001] The invention relates to the technical fields of biomedical measurement and medical equipment, in particular to a watch-type non-invasive photoacoustic blood sugar monitor. Background technique [0002] At present, invasive or minimally invasive interventional methods are still commonly used for blood glucose testing, which require a small amount of peripheral blood and corresponding test strips, and the future development direction should be non-invasive non-invasive blood glucose testing techniques, such as photoacoustic analysis , spectral analysis, Raman spectroscopy, light scattering spectroscopy and optical polarization spectroscopy and other optical means. There are still many difficulties in the current photoacoustic analysis method. For example, due to the need for non-destructive detection, the energy of the incident laser cannot exceed the threshold value. Therefore, it is an urgent problem to be solved to effectively improve the photoacoust...

AI Technical Summary

Problems solved by technology

There are still many difficulties in the current photoacoustic analysis method. For example, due to the need for non-destructive detection, the energy of the incident laser cannot exceed the threshold value. Therefore, it is an urgent problem to be solved to effectively improve the photoacoustic excitation efficiency.

In addition, photoacoustic detection mostly uses solid-state lasers as excitation sources, and there are certain difficulties in system integration and miniaturization.

[0003] In 2001, Z.Zhao and R.Myllyla, "Photoacoustic determination of glucose concentration in whole blood by a near-infrared laser diode" Proc.SPIE, 4256, 77-83, 2001. reported photoacoustic blood glucose based on near-infrared laser diode excitation Concentration measurement method, but the detection method of the forward mode is difficult to apply clinically, and the confocal structure cannot be realized, the sensitivity of the system is very low, and the collected photoacoustic signals need to be averaged thousands of times

In 2003 A.A.Bednov, E.V.Savateeva, A.A.Oraevsky, "Glucose monitoring in wholeblood by measuring laser-induced acoustic profiles" Proc.SPIE, 4960, 21-29, 2003. Reported a photoacoustic blood glucose detection method based on the lateral detection mode, A high-power Nd:YAG laser is used as the excitation source, and the collected photoacoustic signals hardly need to be averaged, but large-volume solid-state lasers cannot achieve true miniaturization and practicability [Non-Patent Document 2]

Moreover, there is still a problem in the above methods. Since a single detector is used as the sensing part, the photoacoustic excitation and sensing cannot achieve a coaxial confocal structure. Therefore, the efficiency of photoacoustic excitation and detection is not high, and a large power is required. The solid-state laser provides photoacoustic excitation energy, or the average of thousands of signals is required to improve the signal-to-noise ratio, while the large-volume solid-state laser cannot realize the integration and miniaturization of excitation and sensing, and the signal average of multiple times is extremely large. The time resolution of the system is greatly reduced, and the forward and side detection modes lack the convenience of actual operation, and the actual promotion and application prospects are greatly limited.

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