The invention relates to a filtration method of real-time junk e-mails, and the method is used for filtering a junk e-mail at a network interconnection point. The method comprises the following steps: step one, a path combination P is constructed according to the routing information in the e-mail, and the path combination P is a sending correspondent and a receiving correspondent, and / or a sending correspondent and an information destination; step two, attribute space mapping is performed to the IP address or the domain name of the elements in the path combination P according to IP address mapping or domain name mapping; steps three, whether the current e-mail is a junk e-mail is determined according to the attribute space mapping result of each element in the path combination P, if the e-mail is a junk e-mail, step four is executed, otherwise, the current e-mail is not processed; step four, the current e-mail is filtered. In the invention, only the mail order and the content in the header are analyzed, the processing speed is quick, the network resource utilization rate can be improved, and simultaneously, the filtration pressure at a user terminal can be relieved.