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Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion

A technology for ureters and catheters, applied in the direction of catheters, devices with human tubular structures, urethra, etc., which can solve the problems of providing renal function and improving kidney function without patients

Pending Publication Date: 2019-12-31
ROIVIOS LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this clinical strategy did not provide improved renal function in patients with cardiorenal syndrome

Method used

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  • Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
  • Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
  • Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion

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example 1

[0304] method

[0305] Four farm pigs 800 were used to assess the effect of negative pressure therapy on renal congestion in the kidneys. Such as Figure 17 A pediatric Fogarty catheter 812 , 814 is shown inserted into the renal pelvis region 820 , 821 of each kidney 802 , 804 of these four pigs 800 . Catheters 812, 814 are deployed within the renal pelvis region by inflating an expandable balloon to a size sufficient to seal the renal pelvis and maintain the balloon's position within the renal pelvis. Conduits 812, 814 extend from the renal pelvis 802, 804, through the bladder 810 and urethra 816, and to a fluid collection container outside the body of the pig.

[0306] Urine output rates were collected for 15 minutes for both animals to establish a baseline of urine output and rate. The urine output rates of the right kidney 802 and the left kidney 804 were measured separately and found to vary greatly. Creatinine clearance values ​​were also determined.

[0307] Renal ...

example 2

[0335] method

[0336] To assess the effect of negative pressure therapy on hemodilution of blood, negative pressure was induced within the renal pelvis of farm pigs. The purpose of these studies was to demonstrate whether negative pressure delivered to the renal pelvis significantly increases the rate of urine output in a porcine fluid resuscitation model.

[0337] Two pigs were sedated and anesthetized with ketamine, midazolam, isoflurane, and propofol. One animal (#6543) was treated with a ureteral catheter and negative pressure therapy as described herein. Another that received a Foley type bladder catheter served as a control (#6566). Following catheter placement, the animals were transferred to a sling and monitored for 24 hours.

[0338] Fluid overload was induced in two animals with a continuous infusion of saline (125 mL / hour) during the 24-hour follow-up period. Urine output was measured in 15-minute increments for 24 hours. Blood samples and urine samples were ...

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Abstract

A ureteral catheter for placement in a kidney, renal pelvis, and / or in a ureter adjacent to the renal pelvis of a patient, includes an elongated tube having a proximal end, a distal end, and a sidewall extending between the proximal end and the distal end of the tube defining at least one drainage lumen extending through the tube; and an expandable retention portion configured to transition from aretracted position to a deployed position and which, in the deployed position, defines a three-dimensional shape positioned to maintain fluid flow from the kidney through at least the distal end of the tube.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Patent Application No. 15 / 687,064, filed August 25, 2017, which is a continuation-in-part of U.S. Patent Application No. 15 / 411,884, filed January 20, 2017, which was filed on Continuation-in-Part of U.S. Patent Application No. 15 / 214,955, filed July 20, 2016, which claims U.S. Provisional Application No. 62 / 300,025, filed February 25, 2016, U.S. Provisional Application No. 62 / 300,025, filed January 14, 2016 Application No. 62 / 278,721, U.S. Provisional Application No. 62 / 260,966, filed November 30, 2015, and U.S. Provisional Application No. 62 / 194,585, filed July 20, 2015, each of which is incorporated by reference Incorporated herein in its entirety. [0003] Furthermore, this application claims priority to U.S. Patent Application Serial No. 15 / 687,083, filed August 25, 2017, which is a continuation-in-part of U.S. Patent Application Serial No. 15 / 411,884, filed January 20, 2017,...

Claims

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Application Information

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IPC IPC(8): A61F2/04A61F2/82A61M25/00A61M25/01A61M25/04A61M27/00
CPCA61F2002/047A61M25/0017A61M27/008A61M2210/1085A61M2210/1082A61M2210/1078A61M25/04A61M1/84A61M1/71A61M1/87A61M1/78A61M1/732
Inventor 约翰·R·厄尔贝二世雅各布·L·厄珀可大卫·E·奥尔
Owner ROIVIOS LIMITED
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