59 results about "Into ureter" patented technology

The invention relates to the technical field of biomedical detection, in particular to a urinary tract epithelium cancer detection marker composition based on ONECUT2 and DMRTA2 gene methylation, which comprises a CpG island region of an ONECUT2 gene, a CpG island region of a DMRTA2 gene and a kit for detecting urinary tract epithelium cancer. The CpG island region of the ONECUT2 gene is located in chr18: 57441548-57441674, and the CpG island region of the ONECUT2 gene is located in The CpG island region of the DMRTA2 gene is located in chr1: 50418714-50418823, and the CpG island region of the DMRTA2 gene is located in chr1: The kit for detecting urothelial carcinoma comprises a first primer pair and a first probe which are used for specifically detecting the methylation state of the CpG island region of the ONECUT2 gene in the claim 1, and a second primer pair and a second probe which are used for specifically detecting the methylation state of the CpG island region of the DMRTA2 gene. The urinary tract epithelium cancer detection marker composition based on ONECUT2 and DMRTA2 gene methylation has high sensitivity and high specificity, the sensitivity and the specificity are both 90% or above, early-stage and low-grade urinary tract epithelium cancer can be effectively detected, comprehensive coverage is achieved, and the urinary tract epithelium cancer detection marker composition is not only suitable for bladder cancer, but also suitable for upper urinary tract epithelium cancer such as renal pelvis cancer and ureter cancer.

The invention provides a sorbitol and mannitol flushing fluid for urinary surgery. The invention relates to a freeze-dried powder injection, which comprises 20 to 50 grams of sorbitol, 10 to 30 grams of mannitol, 5 to 10 grams of sodium bicarbonate and 0.5 to 2 grams of sodium citrate in every 1000 milliliters of the freeze-dried powder injection, and the pH value of the freeze-dried powder injection is adjusted to 7.2 to 7.4. The preparation method comprises the following steps: heating distilled water to 80 DEG C, sequentially adding the components, continuously stirring until the components are completely dissolved, cooling to room temperature, fixing the volume to 1000ml, adjusting the pH value by using a 5mol / L sodium hydroxide solution, finally sterilizing by using a 0.22-micron microporous filter membrane, and packaging in a sterilized glass bottle. The flushing fluid can effectively dissolve blood clots, stones and necrotic tissues in an operation field by utilizing the high osmotic pressure characteristics of the sorbitol and the mannitol, so that the operation field is kept clear. The flushing fluid disclosed by the invention shows an excellent flushing effect and good safety in urinary surgery operations such as transurethral bladder tumor electrocision, flexible ureteroscope calculus removal and the like.

The utility model belongs to the technical field of medical instruments, and particularly relates to a support tube for ureter skin stoma, which comprises a diversion catheter and a connecting portion, drainage holes are arranged on the diversion catheter, the diversion catheter comprises a middle tube body and a fixing portion, the middle tube body comprises a first tube body and a second tube body, and the first tube body and the second tube body are connected through the connecting portion. One in-vitro end of the first tube body is connected with one in-vitro end of the second tube body through the connecting part, the fixing part can deform, the fixing part extends outwards in the radial direction in the natural state, the connecting part is provided with a flow guide groove used for guiding and discharging urine out of the body, the stent of the structure does not need to go deep into the renal pelvis of a patient, and the risk of kidney infection of the patient is reduced; the support effect is achieved on the ureteral obstruction of the passing section caused by abdominal wall muscles and fat; meanwhile, operation is easy, replacement is convenient, and the workload of patients and medical staff is relieved.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

The invention discloses a urine collection device for neonatal care. The urine collection device comprises a diaper, a urine collection assembly, a urine conveying pipe and a urine storage bag, the skin-friendly layer of the diaper is in contact with baby skin; the urine collection assembly comprises an annular positioning seat, a first wrapping structure and a second wrapping structure, and the annular positioning seat is arranged on the skin-friendly layer; the first wrapping structure is arranged on the annular positioning seat, a first root part of the first wrapping structure supports the first wrapping ring, and a flow guide channel is formed in the center of the first root part; the first wrapping ring can flexibly wrap the penis of the baby boy or can be attached to the private part of the baby boy so as to prevent urine from flowing back and overflowing; the second wrapping structure is arranged on the periphery of the first wrapping structure in a surrounding mode, and a second root of the second wrapping structure supports the second wrapping ring; the second wrapping ring is attached to the skin of the baby so as to secondarily seal the overflowing urine; urine enters the urine storage bag for storage through the flow guide channel and the urine conveying pipe; and the urine storage bag is provided with a sampling port for extracting urine. The purpose of the invention is to prevent urine from flowing back, so that the urine collection efficiency is improved.

The utility model discloses a medical sheath, and belongs to the technical field of medical instruments. Comprising a working sheath and a matching sheath, the matching sheath comprises a matching sheath tube and a matching sheath tube seat, the matching sheath tube seat comprises a fixing part, the matching sheath tube is connected to one end of the fixing part, a clamping column is arranged at the other end of the fixing part, the fixing part is axially provided with a hollow cavity with the inner diameter changing in a stepped mode, and the clamping column is axially provided with a through cavity with the inner diameter changing in a stepped mode. Detachable nuts are arranged at the ends, away from the fixing pieces, of the clamping columns. The working sheath is connected and matched with the matching sheath, an installation foundation is provided for the endoscope, the endoscope is integrated in the medical sheath, direct-view observation and real-time operation in the sheath entering process are achieved, the sheath entering difficulty and the ureter injury risk caused by a view blind area in traditional sheath entering operation are effectively solved, and the sheath entering efficiency is improved through real-time image feedback of the endoscope. An operator can adjust the sheath entering angle and force, the operation safety and success rate are improved, the medical sheath does not need ray assistance, and potential hazards of ray radiation to the operator and a patient are avoided.

The technology described herein is directed to methods of administering a therapeutic composition, such as recombinant adeno-associated virus (rAAV), to a kidney of a subject using a retrograde ureter route, for example, to at least renal papilla of the kidney. Such administration methods can be used to treat a kidney-associated disorder in a subject in need thereof. Also described herein are pharmaceutical compositions comprising a recombinant adeno-associated virus (rAAV) for administration to the kidney.

The utility model discloses a self-expanding umbrella-shaped extractor which comprises a handle. An outer pipe is fixed in the handle, and the outer pipe penetrates out of one end of the handle and extends to the outside; an inner pipe capable of moving in the axial direction of the outer pipe is arranged in the outer pipe, a blocking component is fixed to one end of the inner pipe, and a blocking film is arranged on the surface of the blocking component. The shape of the self-expanding umbrella-shaped ureteral calculus blocking and removing catheter can be accurately controlled manually, the self-expanding umbrella-shaped ureteral calculus blocking and removing catheter can be easily placed in a ureter, calculus cannot be pushed to retrograde to the kidney, ureteral wall damage cannot be caused, the opening diameter of the umbrella shape can be adjusted timely to completely block the ureter, and the catheter is convenient to use. The calculus and calculus fragments are effectively prevented from being flushed back into the kidney by perfusion water flow, the condition of calculus incarceration is not prone to occurring, deformation and ureter wall friction are not prone to occurring in the dragging and calculus removing process, all calculus can be taken out at a time, and the purpose of efficient calculus removal is achieved.

A urinary system calculus journey explanation model effectively solves the problem of inconvenient use of existing urinary system calculus journey explanation devices; including a support plate, the left and right sides of the front end of the support plate are respectively provided with a renal pelvis model, the front end of the support plate is provided with a bladder model located below the two renal pelvis models, the left and right sides of the front end of the support plate are respectively provided with ureter models located between the renal pelvis models and the bladder model, the upper end of the ureter model is communicated with the corresponding side of the renal pelvis model and the lower end is communicated with the bladder model, the lower end of the bladder model is communicated with a urethra model, a Y-shaped moving groove is opened on the support plate, the renal pelvis model, the ureter model, the bladder model and the urethra model are provided with a communication groove communicated with the moving groove, the left and right sides of the moving groove are respectively provided with front and rear axial sliding columns, and the front end of the sliding column is detachably connected with a calculus model; this structure is simple, novel in design, convenient to use and high in practicality.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

Embodiments of the present disclosure generally relate to medical aspiration devices and methods of use thereof. In some cases, the devices are configured to generate a vacuum to capture and / or immobilize solid deposits at a location within a subject. Such configurations can be useful, for example, for removing intact kidney stones that are small enough to pass through a ureter. In some cases, the devices further include ablation instruments. Such devices can be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location within a subject (e.g., ablating a kidney stone that is too large to pass through a ureter). In some cases, the vacuum generated by the devices is used to remove the plurality of smaller particles from the location within the subject.

The invention provides a product and a method for detecting urinary tract epithelial carcinoma based on DNA methylation, and belongs to the technical field of urinary tract epithelial carcinoma detection, the product comprises reagents for detecting methylation of the following DNA regions: a PENK gene CpG island region Chr8: 56446618-56446724, a TMEM106A gene CpG island region Chr17: 43211685-43211847, and an OTX1 gene CpG island region Chr2: 63056808-63056956. Through joint detection of the target gene areas, accurate prediction of urothelial carcinoma is realized, and the kit has comprehensive coverage (bladder cancer, pelvis cancer and ureteral cancer) and detection advantages of early and low-grade cancers, can be used for early screening, postoperative recurrence monitoring, prognosis evaluation and other stages, and has a wide application prospect in the fields of early screening, postoperative recurrence monitoring, prognosis evaluation and the like. The positive significance is realized on the whole disease course management of the urothelial carcinoma.

Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1 N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.

The utility model discloses an anti-reflux ureteral stent, which belongs to the technical field of ureteral stents and comprises a stent pelvis section, a stent ureteral section and a stent bladder section. At least one hollow expansion part is arranged on the tube wall of the bladder section of the stent, and an integrated anti-reflux valve is arranged in a tube cavity of the expansion part. The valve is composed of a plurality of valve-shaped structures, the free ends of the valve-shaped structures can be close to each other to seal a lumen when subjected to retrograde liquid pressure from the bladder to the kidney, the free ends of the valve-shaped structures are separated from each other to open the lumen when subjected to forward liquid pressure from the kidney to the bladder, and therefore one-way drainage of urine is achieved. The anti-backflow urine bag is simple in structure and capable of effectively preventing backflow of urine and complications such as lumbago and hydronephrosis caused by backflow of urine. Meanwhile, due to the structure of the expansion part, the valve can be completely attached to the wall when opened, and operation smoothness and safety are guaranteed when a guide wire is placed in.

The invention relates to medical equipment, in particular to a ureteral stent tube with a spherical bladder section (3). The technical problems that a traditional double-pigtail ureter support pipe needs to be placed under direct vision, bladder stimulation is obvious, and no anti-reflux structure exists are solved. The bladder section (3) of the ureteral stent tube is designed to be in a sphere-like shape, the function of a limiting head can be achieved, the ureteral stent tube can be placed in place without endoscope monitoring, stimulation of a thin tubular structure to the bladder can be avoided, and meanwhile the interior of the sphere-like structure can provide enough space for containing an anti-reflux one-way valve (6). Comprising a renal pelvis section (1), a ureter section (2) and a bladder section (3), the renal pelvis section (1) is in a bent tube shape, the ureter section (2) is in a straight tube shape, the bladder section (3) is of a sphere-like structure, the sphere-like structure of the bladder section (3) comprises a round ball, a flat ball, a hemisphere, a heart shape, a concave core ball and the like, the ureter section (2) is directly connected with the bladder section (3), and drainage holes can be formed in the wall of the sphere-like structure of the bladder section (3). And structures such as an anti-reflux one-way valve (6) can be arranged inside.

The utility model discloses a novel urinary catheter, which belongs to the technical field of urinary catheters and comprises a urinary catheter used for draining urine of a patient and facilitating calculus crushing of the patient and a flexible ureteroscope holmium laser device used for crushing and removing the calculus of the patient. The front end of the catheter is provided with a urine hole position used for discharging urine of a patient, the front end of the catheter is further symmetrically provided with two drainage holes, the device further comprises a guide wire, and the guide wire can be placed into the position where stones need to be broken through the catheter. The guide wire stretches out of the corresponding drainage hole through the water injection opening and is finally placed in the lithotripsy position, then the guide wire enters the position needing lithotripsy from the guide wire path through the flexible ureteroscope holmium laser equipment to be crushed and taken out, and the effect that the catheter can assist the flexible ureteroscope holmium laser equipment in guiding is achieved. And the situation that the flexible ureteroscope holmium laser equipment is in large contact with the patient to cause injury is avoided.

The utility model belongs to the technical field of medical equipment, and provides a home body position calculus removal guiding device which comprises a fixed base, a movable base and a guide rod. The kidney model is arranged on the fixed base, a ureter is arranged on the kidney model, and the kidney model is a transparent material model; a renal pelvis cavity, a kidney large calyx cavity and a kidney small calyx cavity are formed in the kidney model, and the ureter, the renal pelvis cavity, the kidney large calyx cavity and the kidney small calyx cavity are used for simulating the ureter, the renal pelvis, the kidney large calyx and the kidney small calyx of the human kidney respectively. The transparent kidney model is convenient for the patient to intuitively observe the movement track of the stone-like member in the kidney model under different body positions. When the kidney model is used, a patient can wear the kidney model at the preset position of the waist, and the body position is changed according to the dynamic condition of the stone-like piece in the kidney model until the stone-like piece is discharged out of the pelvis. Therefore, the cost of the body position drainage bed for the patient is reduced, the hospital return frequency of the patient is reduced, and the body position calculus removing efficiency of the patient is improved.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

A medical urology device for drug delivery to the lining and deeper tissues of the ureter and kidney. The present invention features an electromotive drug administration (EMDA) catheter device for deploying a fluid to deep tissues of a patient. The device includes a catheter body with fenestrations along its distal length. The device may further comprise a multiport component for allowing access to the catheter body. The device may further comprise a conductive wire removably disposed through the multiport component within the catheter body. Fluid may be directed through the multiport component and the plurality of fenestrations to the body structure of the patient. Electrical stimulation directed through the conductive wire enhances the penetration of medications with the same polarity to electrical stimulation into a body structure of the patient to allow the fluid to penetrate deep tissues.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

The embodiment of the specification provides a ureter tunnel opening system and device based on extensive hysterectomy, and relates to the field of intelligent medical treatment. The system comprises: a surgical field acquisition module configured to acquire a surgical field image after a bladder and bilateral ureters have been dissociated in the implementation of C-type extensive hysterectomy; a tissue structure positioning module configured to position relevant tissue positions according to the surgical field image; a double vertical plane forming module configured to form a vertical plane including a bladder plane perpendicular to a uterine longitudinal axis horizontal plane and a proximal ureter perpendicular to a bladder cervix ligament anterior leaf; a Z-type gap positioning module configured to separate a Z-type gap free of blood vessels; and a tissue resection module configured to open a ureter tunnel, process blood vessels of the ureter tunnel below the ureter, and resect abdominal parametric tissue in a preset range. The application proposes a new gap dissection which can quickly and safely open the ureter tunnel and reduce the risk of ureter injury.

The present application relates to a kind of traditional Chinese medicine composition for treating calculus, raw material is: walnut kernel 25-35 parts, black fungus 10-20 parts, giant knotweed 15-25 parts, powder 25-35 parts of yam, sea gold sand 25-35 parts, 10-20 parts of yujin, 25-35 parts of huashi grass, 25-35 parts of shaddock, 10-20 parts of goose tube stone, 25-35 parts of yiwren, 10-20 parts of magnolia officinalis, 25-35 parts of xuanming powder, 10-20 parts of rhubarb, 10-20 parts of plantago, 10-20 parts of bupleurum, 10-20 parts of small chrysanthemum, 5-10 parts of cumin, 10-20 parts of Sichuan donkey's hide, 5-10 parts of raw licorice.The present application has the effect of clearing heat and promoting bile secretion, dissolving stone and stopping bleeding cooling blood, through the concept of dissolving stone and expelling stone, large stone is small, small stone is small, gallstones are discharged with bile into intestine, kidney stones, ureter and bladder stones are discharged with urine, adjust liver, gallbladder, kidney and other qi stagnation, and be supplemented with constitution conditioning syndrome differentiation treatment, it has good curative effect on various stones of liver, gallbladder, kidney and urinary tract, and it is both the treatment of principle and secondary, relieve the suffering of the majority of patients.

Systems and methods are provided for treating indications associated with a urological organ (e.g., bladder, kidney, prostate, ureter, or urethra, etc.).

An implantable medical device for use as an artificial urinary bladder can include a collection container configured to be placed in a patient's abdominal cavity and a pump configured to be subcutaneously placed outside the abdominal cavity to allow the patient to perceive the need for urination and controls timing of the urination. Flexible tubing can connect the patient's ureters to the collection container through anti-reflux valves preventing urine from flowing back to kidneys, connect the collection container to the pump through a unidirectional connection valve, and connect the pump to the patient's urethra through a unidirectional urethral valve to allow for urination through the patient's natural urethra.

The utility model belongs to the CT enhancement scanning auxiliary device field especially, and it is more particularly to a urinary system abdominal compression enhancement CT scanning pressurization restraint device. The technical includes the restraint band, the restraint band front side inner wall is provided with the pressurization piece, and the pressurization piece is oval structure, and the restraint band front side outer wall is provided with the adjusting assembly for driving pressurization piece left and right movement. The utility model discloses through the cooperation of restraint band and pressurization piece, is convenient for when scanning and places pressurization piece in patient abdominal side bilateral sacroiliac joint level, delays contrast agent excretion, makes contrast agent temporarily in ureter renal pelvis calyx, renal pelvis calyx expansion, and then utilizes post-processing technology to make contrast agent and lesion show good contrast, thereby benefit the position of judging stone and the relationship with renal pelvis, calyx, ensure the accurate detection and evaluation of kidney stone, also convenient for adjusting the position of pressurization piece according to different patients during use, make the stability and accuracy of scanning result higher while making the applicability higher.

The invention relates to the technical field of animal model construction methods, in particular to a construction method of a BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine) induced upper urinary tract urothelial carcinoma animal model, according to the method, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine is used for conducting drinking water administration treatment at different stages and with different concentrations on a mouse, and the in-situ tumorigenesis upper urinary tract urothelial carcinoma animal model is formed through induction. According to the technical scheme, the problem that in the prior art, BBN can only induce urothelium carcinoma mainly including bladder cancer can be solved, the whole development stage of animal pelvis cancer and ureteral cancer from early abnormality to advanced cancerization can be observed through the upper urothelium carcinoma animal model constructed through the technical scheme, and the mechanism of different disease courses can be researched conveniently. The animal model is expected to further explain the occurrence and development mechanism of the upper urinary tract epithelial cancer and screen new therapeutic drugs, and has ideal application prospects.

The utility model discloses a wearable urine collector, which is applied to the field of urine collectors and comprises a wearable pocket, a waistband is sewed at the top of the wearable pocket, and elastic bands are sewed at two ends of the waistband; a wrapping layer is sewn at the top of the wearing pocket, and the wrapping layer is filled with a urine absorbing layer; the front surface of the wearing pocket is fixedly connected with a urine collecting opening, and the bottom end of the urine collecting opening is communicated with a urine conveying pipe; through the arrangement of the elastic band, the waistband can be suitable for patients with different waistlines to wear; by arranging the wrapping layer and the urine absorbing layer, urine splashed when a patient urinates after wearing the urine collector can be absorbed, and discomfort caused by the fact that the urine adheres to the skin of the patient is reduced. By arranging the valve, the connecting pipe and the two collecting bags, after one collecting bag is full of urine, redundant urine can be transferred into the other collecting bag to be stored, the problem of urine backflow can be avoided, and meanwhile more urine can be stored.

This invention provides a multi-instrument intelligent collaborative training method based on respiratory motion phase determination, comprising the following steps: constructing a three-dimensional virtual anatomical model including the urethra, bladder, ureter, and kidney, and establishing an interactive connection between the force feedback handle of the simulated surgical instrument and the three-dimensional virtual anatomical model; selecting respiratory samples from a preset database and sending them to the three-dimensional virtual anatomical model, which then simulates the changes in other organs and tissues during lung respiration; collecting kidney motion data from the three-dimensional virtual anatomical model and dividing the kidney motion phase based on the motion data; generating instruction commands based on the kidney motion phase and the surgical instrument, and visually displaying the instruction commands; and having the user perform simulated training through the force feedback handle according to the instruction commands, with reinforcement learning used to optimize the training movements. By introducing kidney motion changes caused by lung respiration, the method can simulate real surgical situations and improve training effectiveness.

Anatomical Model for Endoscopic Exploration of a Hollow Organ with Microvascularized Mucosa. The invention relates to an anatomical model (1) for endoscopic exploration comprising an anatomical assembly (2) which is a physical reproduction of at least one hollow organ (3), comprising a cavity (9, 10) delimited by a wall (11, 12). This anatomical assembly includes, at least on the inner surface (15, 16) of its wall, a polychrome representation (32) of a microvascular network produced by additive manufacturing. This polychrome representation may advantageously include a pattern (35) simulating a pathology resulting in a localized modification of the appearance of the microvascular network. The anatomical assembly is, for example, a reproduction of a bladder (6), a urethra (5), two kidneys (8), and two ureters (7). Figure to be published with the abbreviation: Figure 3

1. Name of the product in this design: Endoscopic device. 2. Application of this design: This design is used in a minimally invasive endoscopic system for urology, to precisely grasp and remove internal catheters and stents of the human urinary system (urethra / bladder / ureter / kidney) under visualization conditions. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.