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Ureteral catheter and preparation method thereof

A technology for ureters and catheters, applied in the field of medical devices and ureters catheters, can solve problems such as inability to use for a long time, coating peeling off, etc., and achieve the effect of resisting the adsorption of non-specific proteins and bacteria

Active Publication Date: 2020-08-25
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Acta Biomaterialia, 2012, 8, 1869–1880 exemplifies an antimicrobial coating on urology catheters by dip-coating a polyurethane layer with salicylic acid on the surface, but because it is physically A layer of functional coating is built on the surface of the catheter, which has the risk of coating peeling off and cannot be used for a long time

Method used

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  • Ureteral catheter and preparation method thereof
  • Ureteral catheter and preparation method thereof
  • Ureteral catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0079]

[0080] The present invention also provides a method for preparing a ureteral catheter, wherein: at least one layer of the lubricating antibacterial layer is formed on the surface of the ureteral catheter, preferably the lubricating antibacterial layer is cured by light curing, thermal curing, chemical reaction, physical adsorption, Formed by crystallization or freezing.

[0081] Formation of lubricating antimicrobial layer

[0082] Preferably, the lubricating antibacterial layer can be coated on the surface of the ureteral catheter when the ureteral catheter is fully dry or half dry.

[0083] As a non-limiting example, a lubricating antimicrobial layer can be formed in the following manner.

[0084] Take an appropriate amount of photocurable polymer (based on the total amount of the coating composition, its mass concentration is preferably 0.5-10%) and antibacterial agent (based on the total amount of the coating composition, its mass concentration is preferably ...

Embodiment 1

[0097] step one:

[0098] (1) Synthesis of water-soluble polymerizable photosensitive monomer

[0099] Weigh 22.4g (100mmol) 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 10.6g (105mmol) triethylamine is dissolved in 100mL dichloromethane and placed in a 250mL flask , placed in an ice-water bath to fully dissolve. 9.1 mL of bromoacetyl bromide (21.1 g, 105 mmol) in dichloromethane was slowly added dropwise to the flask, and the dropwise addition was completed within 1 h. After reacting for 0.5 h under ice-bath conditions, the reaction was continued for 10 h at room temperature. After the reaction was completed, cool to room temperature and dissolve the crude product in dichloromethane, wash twice with saturated brine, hydrochloric acid (1M) and saturated sodium bicarbonate successively, dry over anhydrous magnesium sulfate, filter and spin dry the solvent, wash with acetic acid Ethyl ester and normal hexane are eluent, obtain 28.8g2-hydroxyl-4'-(2-hydroxyethoxy brom...

Embodiment 2～7

[0117] In Step 2 of Example 1, different concentrations of silver nanoparticles were used to prepare a series of coating liquid compositions (respectively Examples 2-7). Other steps were the same as in Example 1, and the lubricating performance and antibacterial performance of the prepared ureteral catheter were evaluated, and the results are listed in Table 2.

[0118] Table 2 Effect of different concentrations of silver nanoparticles on the performance of ureteral catheter coating

[0119]

[0120] It can be seen from Table 2 that a solid lubricating antibacterial layer can be constructed on the surface of the ureteral catheter through the present invention, and for different concentrations of silver nanoparticles, the prepared lubricating antibacterial layer is firmer and has a higher bactericidal rate.

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Abstract

The invention relates to a ureteral catheter and a preparation method thereof. The ureteral catheter has at least one lubricating antibacterial layer formed on the surface of the ureteral catheter; and preferably, the lubricating antibacterial layers are formed through light curing, heat curing, chemical reaction, physical adsorption, crystallization or freezing. The ureteral catheter has good long-term hydrophilic lubrication performance, efficient antibacterial performance and excellent biological safety, and is high in surface coating firmness and uniform in coating.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to the field of ureter catheters with lubricating and antibacterial layers. Background technique [0002] Ureteral calculus combined with refractory renal colic is very common clinically. Some patients with ureteral calculus and renal colic have inaccurate curative effects of conventional treatment. Failure to restore and drain the affected side of the kidney in time may lead to renal function damage, urosepsis, bilateral ureteral calculi and solitary renal colic. Pain can cause renal failure, and renal colic in pregnant women can lead to miscarriage and premature delivery. Patients with renal colic combined with underlying diseases such as diabetes and chronic cardiopulmonary disease may suffer from urogenous shock and death. In addition to symptomatic treatment and drug expulsion of stones, ureteroscopic lithotripsy, and nephrostomy drainage, retrograde ureteral catheterization and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/10A61L29/16
CPCA61L29/085A61L29/106A61L29/16A61L2300/104A61L2300/404A61L2300/602A61L2300/606A61L2420/06
Inventor 雷杰华李业
Owner JIANGSU BIOSURF BIOTECH CO LTD
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