30 results about "Removal tumor" patented technology

A cutter (8) is telescopically received in a cannula (9) and both the cutter and cannula are telescopically mounted on a tubular carrier (7). A detection device (6) may be inserted through the open-ended carrier, cutter and cannula to properly place the surgical instrument in alignment with the tumor to be excised. Positioning tines (80) may penetrate the patient to firmly locate the carrier in its proper position on the patient. The cutter and cannula are moved about the carrier and are pressed into the tissue of the patient with the expectation that the circular core (60) of breast tissue formed by the cutter will have clear margins about the tumor. If the tumor extends too close to the circular incision, the cannula may be rotated so that its sidewall opening (26) faces the side of the remaining tissue to be excised and the surgeon can pull the remaining tissue through the sidewall and excise it, thereby avoiding a separate and delayed surgical procedure.

The invention discloses a medicine carrying injectable implanted in-situ hydrogel which is characterized by being formed at an injection part in situ on the basis of a Schiff base reaction in a chemical bond cross-linking mode, and the hydrogel has self adaptability to the shape of an injection cavity, and is long in retention time in the cavity, and medicines are in controlled release. The hydrogel is used for filling of cavities after a tumor operation, the cavities can be rapidly filled through flowability of the in-situ hydrogel, the hydrogel can be in close contact with edge tissue aftertumor excision, residual tumor cells can be well eliminated, and a remarkable effect of preventing tumor recurrence can be achieved.

The invention discloses a laparoscopic device for bloodless isolation, protection and excision of tumors. The device is characterized by being composed of a sealing push pipe, a guide supporting rod, an elastometric ring, a sealed sheath pipe protection bag and a base, wherein the sealing push pipe is of a hollow tubular structure, one end of the sealing push tube is provided with an internal opening, the pipe wall of the sealing push pipe is provided with leakage holes communicated with a pipe cavity, the other end of the sealing push pipe is provided with an external opening, an anti-air-leakage cap covers the external opening, and the pipe wall of the sealing push pipe is provided with an air inflation and deflation pipe and an air inflation and deflation switch; the guide supporting rod penetrates through the sealing push pipe, and one end of the guide supporting rod is connected with the elastometric ring; the elastometric ring is connected with a sealed sheath pipe protection bag mouth; a bag body is communicated with multiple sheath pipes, the sheath pipes are of tubular structures, the other ends of the sheath pipes are provided with threaded ports, and the threaded ports not only can be connected with a sealed cap, but also can be connected with the base; the base is internally provided with an unidirectional anti-air-leakage valve and a tee pipe. The device is used for laparoscopic tumor excision, not only blocks blood supply in tumor vessels, but also is isolated from other normal tissue organs in the abdominal cavity, and aims at preventing hemorrhage during operation and celiac implantation contamination by tumor cells.

An enucleator and method of use for resection of tumors, especially tumors of the bladder. The enucleator has a plurality of tentacles that are selective extensible and retractable from an elongate body. In a deployed, extended position, the tentacles may be positioned to surround the tumor and tumor stalk. The ends of the tentacles have a razor tipped edge that are oriented inwardly to surround. Utilizing the energy source at the tip of the razor ends, cut through the tumor stalk will finalize the enucleation en-bloc of the whole tumor in one piece.

The invention relates to the technical field of oncology, in particular to a positioning device for assisting tumor excision, and overcomes the defects that the existing gastroscope is simple in structure and cannot position tumors. The positioning device comprises a lens and a stomach tube connected with the lens, wherein a probe, a water inlet and a water outlet are respectively mounted in the lens, a clamping motor is fixed in one side of the lens through bolts, a wire passing pipe is laid in the stomach tube, an opening is formed in one side of the lens, the lens is connected with a clamping rod connected with an output shaft of the clamping motor through an opening rotating shaft, the outer portions of the two ends of the clamping rod are sleeved with connecting blocks correspondingly, a horizontally-arranged transverse rod is welded to one side of the bottom of each connecting block, the transverse rod is sleeved with a supporting block and a first chuck, after the first chuck and a second chuck are conveniently driven to clamp and fix tumor soft tissue, transverse stripping can be conducted through the transverse rod, the chuck made of metal is left on a tumor, the positionof the tumor can be conveniently detected in real time through metal detection equipment, and the positioning effect is good.

The invention discloses a construction method of a glioma cell line suitable for two-photon living imaging. The construction method comprises the following steps: constructing a glioma cell in-situ transplantation animal model through glioma cells, and researching the dynamic development change of the glioma cells in the brain of a mouse by virtue of a two-photon living body imaging technology. The GL261-ZsGreen glioma cells obtained through transformation can be successfully used for constructing a glioma in-situ transplantation living animal model, the positions of tumor cells can be clearlyobserved in the imaging observation process, cell-level examination can be accurately performed when the GL261-ZsGreen glioma cells are applied to the research field, the glioma boundary can be obviously distinguished, and a potential means is provided for effectively and accurately excising tumors. Each proliferated GL261-ZsGreen cancer cell is provided with a green fluorescence label, so that single cancer cells subjected to dispersive metastasis can be accurately positioned, and a possible scheme is provided for further researching the diffusion of cancer cells and the accurate treatment of glioma.

The invention discloses a postoperative recurrence risk assessment method and system for a high-risk gastrointestinal stromal tumor patient. The method comprises the following steps: inputting original clinical data of preoperative hematological indexes and postoperative pathological indexes of a high-risk GIST patient; preprocessing the original clinical data, and calculating a preprocessing index; calculating a high-risk stromal tumor recurrence risk score according to original clinical data and the preprocessing index; and respectively carrying out qualitative and quantitative prediction scoring on a specific patient individual according to a high-risk stromal tumor recurrence risk scoring result, evaluating the prognosis and targeted therapy benefits of the patient after tumor excisionby an operation, and providing prediction and analysis results. The high-risk interstitial tumor recurrence risk score is calculated on the basis of the extracted indexes, experiments prove that thehigh-risk interstitial tumor recurrence risk score can objectively and accurately evaluate the recurrence risk of high-risk gastrointestinal interstitial tumor patients, and the defects of a traditional NIH grading system are overcome.

The invention provides an isolation device for preventing tumor cells from falling off under a laparoscope, which belongs to the technical field of laparoscopic surgery auxiliary devices and comprisesa tumor cell isolation bag, a glue spraying pipe and an injection device filled with biological albumen glue. The tumor cell isolation bag comprises a flexible fixing layer and a gauze layer; whereinthe flexible fixing layer is made of medical plastic or medical rubber, the edge of the flexible fixing layer is sewn or bonded with the gauze layer, the flexible fixing layer and the gauze layer define a biological albumen glue filling space, the shape of the flexible fixing layer and the shape of the gauze layer are matched with the shape of a tumor cell exposed surface, and the gauze layer isattached to the tumor cell exposed surface; the front end of the glue spraying pipe penetrates through the flexible fixing layer and extends into the bioprotein glue filling space, and the rear end ofthe glue spraying pipe is connected with a glue outlet of the injection device. The device can be placed in the abdominal cavity before tumor cells are excised, falling tumor cells or overflowing tumor cell contents are prevented from dispersing in the abdominal cavity, are isolated from a human body and are prevented from being in direct contact with normal human tissues and organs, so that theaim of preventive treatment is fulfilled.

A method of characterizing a glioblastoma multiforme (GBM) stem cell (GSC), comprising culturing the GSC to provide a culture, contacting a first set of aliquots of the culture with individual compounds selected from a panel of compounds, identifying two or more of the selected compounds that cause more than a threshold level of cell death in the first set of aliquots, and characterizing the GSC as suitable for treatment with one or more combinations comprising the two or more identified compounds. A panel of chemical compounds, the compounds selected by a method comprising surgically resecting the tumor, culturing a GSC derived from GBM tissue derived from a GBM tumor, contacting aliquots thereof with individual compounds selected from a panel of compounds, and identifying two or more of the selected compounds that cause more than a threshold level of cell death in the aliquots, thereby identifying the compounds.

The invention relates to methods for locally delivering a chemotherapeutic agent to an upper tract urothelial carcinoma (UTUC). The methods involve placing a balloon catheter that has a working channel and a balloon into the ureter/renal pelvis via retrograde or antegrade ureteral access; inflating the catheter balloon to temporarily obstruct the ureter; infusing (instilling) a liposomal formulation that includes a chemotherapeutic agent into the working channel of the catheter; and allowing the infused liposomal formulation to dwell in the ureter and/or renal pelvis for a time sufficient to allow at least a portion of the liposomal formulation to adhere to the urothelial wall. In the methods of the invention, at least a portion of the infused chemotherapeutic-agent formulation adheres to the urothelial wall while it is instilled and dwells in the ureter and/or renal pelvis. The disclosed methods can be performed as an adjuvant therapy to other methods of treating UTUC, such as ureteroscopic ablation or resection of the tumor.

Systems and methods for performing minimally invasive surgical procedures, especially for removal of tumors, and especially for brain tumors, using a robotically inserted therapeutic probe, which first detects tumorous tissue on a pre-planned path through the patient's tissue, before performing therapeutic procedures on the tissue, such as ablation. This pre-treatment detection procedure is thus able to avoid the destruction of healthy tissue. This also ensures that the therapeutic process indicated in a preoperative surgical plan is only performed on tumorous tissue, without sole reliance onpreoperative image indications. This is important for neurosurgical operations performed on the brain, since preoperative images may not be accurate due to brain shift occurring during the procedure.Detection can be performed optically or ultrasonically, and treatment by laser or RF ablation. The probe insertion can be performed at 90 degrees to the insertion axis of the device, thus minimizing passage through healthy tissue.

The invention relates to the technical field of oncology department, in particular to a positioning device for assisting in tumor excision. The positioning device overcomes the defects that an existing gastroscope is simple in structure and cannot position the tumor position. The positioning device comprises a lens and a stomach tube connected with the lens, a probe, a water inlet and a water outlet are separately mounted in the lens, a clamping motor is fixed in one side of the lens through a bolt, a wire passing tube is laid in the stomach tube, a notch is formed in one side of the lens, the lens is in rotating shaft connection with a clamping rod connected with an output shaft of the clamping motor, two ends of the clamping rod are each sleeved with a connecting block, and a horizontally-arranged transverse rod is welded to one side of the bottoms of the connecting blocks. A supporting block and a first clamping head are arranged in a sleeved mode through the transverse rod, after the first clamping head and a second clamping head are conveniently driven to clamp and fix tumor soft tissue, transverse stripping can be conducted through the transverse rod, the metal clamping heads are left on the tumor, the position of the tumor can be conveniently detected in real time through metal detection equipment, and the positioning effect is good.

The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme).

The invention belongs to the field of medical devices and equipment, and particularly relates to a medical catheter structure, a purpose and a use method. The medical catheter structure disclosed by the invention mainly comprises a soft thick casing pipe I, a soft thick casing pipe II, connecting ends II, a pipeline blood flow control device and a blood flow detection meter. When a catheter bridging manner is used, tumor tissue, invaded aorta or other artery vessels can be safely and completely excised, the problem that a malignant diseased region is difficult to be subjected to a surgery is solved, and the medical catheter structure can be further widely applied to the field of medical care.

The invention belongs to the field of tissue engineering scaffold materials and particularly relates to a near-infrared-light-sensitive ZIF8 functionalized gelatin nanofiber scaffold system and application thereof. The ZIF8 functionalized gelatin nanofiber scaffold system comprises a gelatin nanofiber scaffold and ZIF8 nanoparticles which are adsorbed onto the gelatin nanofiber scaffold and are subjected to calcination treatment. The invention finds that the ZIF8 nanoparticles have near-infrared-light-sensitive characteristics after being calcined, and can kill tumor cells under the action of near-infrared light stress. The ZIF8 functionalized gelatin nanofiber scaffold system disclosed by the invention is implanted into a defect part after bone tumor excision, and under the action of NIR, a temperature of a GF/ZIF8-phenamil scaffold is increased, so that residual tumor cells are killed. In practical application, in-situ transplantation can be adopted, the requirements of residual tumor cells and bone defect generation after tumor tissue excision can be met, and a new choice is provided for clinical bone tumor treatment.

The gastric cancer surgical instrument comprises a gastroscope, a laparoscope, intestinal forceps and a resection device, the gastroscope comprises a control panel, a gastroscope illuminating lamp, a gastroscope indicator and a gastroscope camera are installed on the control panel, and an irradiation range changing mechanism matched with the gastroscope illuminating lamp is arranged on the control panel. The intestinal forceps comprise an intestinal forceps frame and two forceps blades connected to the intestinal forceps frame. The tumor excision forceps have the advantages that the manual screw rotates to drive the U-shaped frame to move, so that the two inclined plates are driven to be opened and closed, the forceps blades are driven to be opened and closed, the forceps blades are automatically fixed after being opened and closed, the function of opening width positioning is completed, the operation time is long during tumor excision, a large amount of blood or even fester exudes from diseased tissue, and the operation difficulty is lowered. In the prior art, a soft catheter, a connecting tube and a drainage device are adopted for drainage and suction, so that the working efficiency is improved.

The invention relates to a multi-point accurate sampling system, method and device for brain tumors. The method comprises the steps of drawing a tumor boundary, and acquiring MRI data in a tumor boundary range; extracting MRI data, and converting the MRI data into a first-order feature, a second-order feature, a shape feature and a texture feature; through three-dimensional reconstruction and spatial clustering, obtaining a cerebral cortex 3D topographic map, and realizing classification of tumor sub-regions; formulating a navigation plan by utilizing the CT data and the MRI data, calibratinga tumor excision range, acquiring reference coordinates of a tumor boundary and a tumor entity, mapping the reference coordinates to an imaging subarea constructed by MRI, and acquiring a central position coordinate and a fault-tolerant boundary coordinate interval of each subarea; importing the reference coordinates of the tumor boundary and the tumor entity into AR equipment, and enabling a tumor focus to be excised; and introducing the cerebral cortex 3D topographic map and the sub-regions into a laser positioning and sampling device in a classified manner, and performing slicing layer by layer by using the laser positioning and sampling device. Accurate positioning and sampling of tumor focuses are realized.

The invention discloses a multi-mode laparoscopic surgery device and an implementation method. The multi-mode laparoscopic surgery device comprises a computer, a hyperspectral imaging system, a photoacoustic imaging system and a laparoscope unit, wherein the computer is used for determining a hyperspectral mode or a photoacoustic imaging mode and sending a control instruction to the hyperspectralimaging system and the photoacoustic imaging system; the hyperspectral imaging system is used for acquiring hyperspectral imaging data according to the control instruction of the computer; the photoacoustic imaging system is used for acquiring photoacoustic imaging data according to the control instruction of the computer; and the laparoscope unit is used for embedding a hyperspectral imaging channel and a photoacoustic imaging channel and guiding completion of abdominal surgery operation according to the hyperspectral imaging data and the photoacoustic imaging data. The multi-mode laparoscopic surgery device improves the recognition accuracy of tumor boundaries in the laparoscopic surgery, can excise tumors to the maximum extent and reduce the recurrence rate under the condition of not damaging adjacent normal tissue, and can be widely applied to the technical field of medical instruments.