24 results about "Removal tumor" patented technology

A neurosurgery system for probing brain tissue of a patient for tumorous tissue. The system including a suction tool, an excitation source, an optical instrument, and a controller. The suction tool including a suction cannula defining a lumen, an optical fiber configured to transmit fluorescence emitted by the brain tissue; and an indicator configured to selectively emit visible light. An excitation source is configured to emit an excitation light having a wavelength to induce the fluorescence in the tumorous tissue. The optical instrument is coupled to the optical fiber. The optical instrument configured to convert the fluorescence emitted by the brain tissue and transmitted by the optical and configured to determine that the brain tissue is tumorous based on the electrical signal and activate the indicator based on the determination.

The invention relates to an exterior mirror system and method for fluorescence imaging, and relates to the technical field of image processing, the system can detect fluorescence under a white light operation condition in a tumor excision process, and imaging in a dark or dim operating room is not needed; white light in the fluorescent light is separated, so that a clear fluorescent light image is presented; in addition, fluorescence images can be displayed in a 3D mode, and development is more visual. According to the invention, the technical problems of dark fluorescence image, poor definition and complicated operation in the developing process in the prior art are solved.

The utility model discloses a plasma bipolar tool bit, which belongs to the field of medical appliances and comprises a first tweezer piece and a second tweezer piece which are oppositely arranged at a set interval, a tweezer tip is arranged at the front end of one of the first tweezer piece and the second tweezer piece, and an annular working head is arranged at the front end of the other one of the first tweezer piece and the second tweezer piece. The plane where the circular ring of the annular working head is located and the inner side faces of the forceps tips are oppositely arranged in parallel. The rear ends of the first tweezers piece and the second tweezers piece are respectively connected with respective leads, and the rear ends of the first tweezers piece and the second tweezers piece are fixed on a connector part. One electrode tip is designed into a circular ring, the circular design can ensure enough working area, and the electrode tip can be used for scraping and cutting the surface of a target tissue. Under the condition that a target operation area does not have a clear boundary, the surface of a target tissue can be scraped and cut, a tumor or surrounding tissue of the tumor is cut off, and intratumor decompression is achieved.

Systems and methods for performing minimally invasive surgical procedures, especially for removal of tumors, and especially for brain tumors, using a robotically inserted therapeutic probe, which first detects tumorous tissue on a pre-planned path through the patient's tissue, before performing therapeutic procedures on the tissue, such as ablation. This pre-treatment detection procedure is thus able to avoid the destruction of healthy tissue. This also ensures that the therapeutic process indicated in a preoperative surgical plan is only performed on tumorous tissue, without sole reliance on preoperative image indications. This is important for neurosurgical operations performed on the brain, since preoperative images may not be accurate due to brain shift occurring during the procedure. Detection can be performed optically or ultrasonically, and treatment by laser or RF ablation. The probe insertion can be performed at 90° to the insertion axis of the device, thus minimizing passage through healthy tissue.

The present invention provides an in vitro or ex vivo method for the transient modification of immune cells in a closed treatment system, comprising the steps of: (i) providing immune cells from a biological fluid and / or from a resected tumor of a patient; (ii) purifying the immune cells; (iii) transfecting the purified immune cells with a suppressive nucleic acid of an immunosuppressive modulator of the immune cells or with a nucleic acid of an immunopotentiator; (iv) buffering the transfected immune cells again into the physiological solution; (v) transferring the transfected immune cells into a container; wherein the transition between steps (i) to (v) is in a closed container system; and therapies using the transfected immune cells.

The present invention discloses a scalpel structure capable of marking positions and a forming method thereof. The method includes: forming a stent that can be expanded or closed; detachably installing a column that can rotate relative to the stent on the stent; installing a laser pen at the lower end of the column for confirming the edge of a tumor; installing a measuring scale near the lower end of the column for measuring the expanded resection range of the tumor edge when confirming the tumor edge; and installing a scalpel at one end of the measuring scale for excising the tumor and the tumor peripheral tissue within the expanded resection range while the measuring scale measures the expanded resection range of the tumor edge. The scalpel structure of the present invention can not only mark and measure the position of the tumor edge, but also determine the expanded resection range at the same time. Meanwhile, it can also excise the tumor and its peripheral tissue. One set of equipment has multiple functions, liberating the doctor's hands, reducing the doctor's workload, making the doctor time-saving and labor-saving during the operation, and improving the operation efficiency.

An in-vitro or ex-vivo method for transiently modifying immune cells in a closed processing system is disclosed. The steps include: (i) providing immune cells from a biological liquid and / or from a resected tumor from a patient; (ii) purifying the immune cells; (iii) transfecting the purified immune cells with an inhibitory nucleic acid of a immunosuppressive regulator of the immune cells or with a nucleic acid of an immune enhancing factor; (iv) rebuffering the transfected immune cells into a physiological solution; (v) transferring the transfected immune cells into a container; wherein the transitions between steps (i) to (v) are in a closed container system; and a therapy using the transfected immune cells.

A neurosurgery system for probing brain tissue of a patient for tumorous tissue. The system including a suction tool, an excitation source, an optical instrument, and a controller. The suction tool including a suction cannula defining a lumen, an optical fiber configured to transmit fluorescence emitted by the brain tissue; and an indicator configured to selectively emit visible light. An excitation source is configured to emit an excitation light having a wavelength to induce the fluorescence in the tumorous tissue. The optical instrument is coupled to the optical fiber. The optical instrument configured to convert the fluorescence emitted by the brain tissue and transmitted by the optical and configured to determine that the brain tissue is tumorous based on the electrical signal and activate the indicator based on the determination.

The invention relates to the technical field of bone defect reconstruction, in particular to a 3D printing guide plate for autologous iliac bone extraction and bone defect reconstruction and a preparation method and application of the 3D printing guide plate for autologous iliac bone extraction and bone defect reconstruction. Tumor excision is simulated in a computer, and a bone defect area three-dimensional model is generated; according to the bone defect area model, the optimal ilium taking position, size, shape and bone taking scheme are determined through computer aided design; designing a bone taking guide plate and a fixing guide plate according to the bone taking scheme, wherein the guide plate is prepared through a 3D printing technology. According to the method, key steps (such as tumor resection simulation, bone taking scheme design and bone grafting fixation simulation) of bone defect reconstruction are all completed under the assistance of a computer, a standardized operation process is formed, and a standardized solution for bone defect reconstruction is constructed.

Described are a carbon-iodine conjugated polymer and preparation thereof, an imaging marker thereof, and uses thereof for preparing a localization marker, and belongs to the technical field of imaging markers. The conjugated structure enables the polymer to have strong absorption in a visible light region, and high iodine content of up to 84.1% corresponds to the strong imaging ability thereof. During surgery, on the basis of the dual guidance of a polymer-based image marker and naked eye observation, the marker can better facilitate determination of tumor resection margins, achieving precise resection of tumors and minimizing damage to surrounding normal tissues. During cyberknife-based treatment, the polymer can replace clinical gold markers to provide ray marker guidance. Absence of metal artifacts improves ray imaging quality and the accuracy of radiation dose distribution, good biocompatibility enhances the stability of the relative position of the marker, and radiotherapy side effects can be further reduced.

The utility model relates to the technical field of medical instruments, in particular to a titanium clip assembly capable of being repositioned, which comprises two single titanium clips provided with pairing marks, each single titanium clip consists of a clamping part, a clamping arm and a marking part, the clamping part is U-shaped or V-shaped, the two clamping arms are respectively connected to two end parts of the clamping part, and the marking part is arranged on the clamping arm. The marking part is fixedly arranged at the end, away from the clamping arm, of the outer side of the clamping part, and a pairing mark is arranged on the marking part. The titanium clamp assembly capable of being repositioned is used for positioning the two sides of an incision edge when a tumor is cut off, the titanium clamp assembly capable of being repositioned is used for positioning the two sides, pathology is taken at the edge of the titanium clamp after the tumor is cut off, if the pathology is positive, the corresponding titanium clamp on the tumor bed side can be found, the positive incision edge is repositioned in a defect area, and expanded cutting is carried out; and the recurrence-free survival rate of the patient with the negative incision edge after supplementary excision is greatly improved.

This invention relates to the field of medical device technology, specifically disclosing a tumor resection device, including a resection mechanism, a body, a handle, a drive mechanism, a transmission mechanism, and an adsorption mechanism. The handle, body, and resection mechanism are sequentially connected. The drive mechanism is installed inside the handle, and the transmission mechanism is installed inside the body and connected to the drive mechanism and the resection mechanism. The drive mechanism drives the resection mechanism to perform tumor resection via the transmission mechanism. The adsorption mechanism is installed inside the handle and body, and when the resection mechanism removes the tumor, the adsorption mechanism removes the removed tumor. The tumor resection device has an elongated structure, and the maximum outer diameter of the cross-section of the tumor resection device is less than or equal to 10 mm. This invention's resection mechanism removes the tumor through the adsorption mechanism, effectively reducing the wound, alleviating patient pain, and lowering surgical risks.

This prostate treatment method includes an insertion step of inserting a balloon coated with a medicine into a urethra, an expansion step of expanding the balloon in a prostate part where the prostate is located in the urethra, and a step of injecting the medicine by piercing the prostate part with a microneedle attached to the surface of the balloon. This bladder tumor treatment method is for treating a bladder tumor having a tumor bulging part and a tumor bottom part, the bladder tumor treatment method being provided with a cutting step of cutting off the tumor bulging part, and a freezing step of freezing the tumor bottom part.

A neurosurgical system for examining a patient's brain tissue for tumor tissue. The system includes an aspiration instrument, an excitation source, an optical instrument, and a controller. The aspiration instrument includes an aspiration cannula defining a lumen, an optical fiber configured to transmit fluorescence emitted by the brain tissue, and an indicator configured to selectively emit visible light. The excitation source is configured to emit excitation light having a wavelength that induces fluorescence in the tumor tissue. The optical instrument is connected to the optical fiber. The optical instrument is configured to transduce the fluorescence emitted by the brain tissue and transmitted by the optical fiber, and is configured to determine that the brain tissue is tumorous based on the electrical signal and activate the indicator based on the determination.

Disclosed herein is a method for determining tumor margins relative to non-tumorous tissue using a deep-learning platform. Also disclosed herein are methods for removing a tumor from a tumor biopsy.

The invention, which relates to the technical field of medical treatment, discloses an artificial intelligence automatic tumor identification system under fluorescence and white light comparison, comprising an image acquisition module, an image processing module, a feature analysis module and a visual interface module. The image acquisition module comprises a laparoscope unit and an endoscope unit and is used for acquiring image data in an operation process in real time; real-time image data is transmitted to the central processing unit through wired connection; the image processing module is responsible for preprocessing the acquired image data, including image denoising, contrast enhancement, artifact correction and data standardization, and removing noise in the image by adopting a filtering algorithm, and the filtering algorithm includes Gaussian filtering and mean filtering. Through accurate tumor recognition and real-time dynamic tracking, a doctor is helped to comprehensively resect tumors in an operation, the residual risk is reduced, and the operation success rate and the patient prognosis are improved.

A neurosurgical system for examining a patient's brain tissue for tumor tissue includes a suction instrument, an excitation source, an optical instrument, and a controller. The suction instrument includes a suction cannula defining a lumen, an optical fiber configured to transmit fluorescence emitted by the brain tissue, and an indicator configured to selectively emit visible light. The excitation source is configured to emit excitation light having a wavelength that induces fluorescence in the tumor tissue. The optical instrument is connected to the optical fiber. The optical instrument is configured to transduce the fluorescence emitted by the brain tissue and transmitted by the optical fiber, and is configured to determine that the brain tissue is tumorous based on the electrical signal and activate the indicator based on the determination.

A method for awake neurosurgical planning and testing includes presenting, to a subject undergoing an awake neurosurgical procedure, during the awake neurosurgical procedure, and using a head mountable device, tests for evaluating neurocognitive or motor functions controlled by a region of the subject's brain being evaluated for tumor resection. The method further includes receiving, by a test controller module, responses of the subject to the tests. The method further includes automatically selecting or generating, by the test controller module, and based on the responses, further tests to present to the subject during the awake neurosurgical procedure. The method further includes presenting, via the head mountable device and to the subject, the tests selected or generated based on the subject's responses.

The utility model discloses a minimally invasive excision device for urinary surgery tumor, which comprises a device main body, the device main body is composed of a resectoscope main body and a resectoscope sheath, one end of the resectoscope main body is provided with a main channel catheter, one end of the main channel catheter penetrates through the resectoscope sheath and extends to the outer side of the resectoscope sheath, and the other end of the main channel catheter is provided with a guide tube. A fixed sleeve is fixedly mounted on the surface of the other end of the resectoscope main body through a bolt; a surgeon holds a guide handle to guide more flexibly, a fixed sleeve, a movable sleeve, a lantern ring supporting piece, a thumb ring, an I-shaped connecting piece, an electrode knife rod and a torsional spring are arranged in a matched mode, the strength of a supporting point is increased when the electrotome head conducts tumor excision, the surgeon presses and pinches the distance between the handle ring and the thumb ring according to needs, and the torsional spring rebounds; and the movable sleeve stably slides on the surface of the guide rod, the movable sleeve drives the electrode cutter rod to stably support, and the working difficulty of tumor operation excision is reduced.

Provided are drug delivery compositions and devices useful for the treatment and / or prevention of cancer and metastatic tumors. For example, a drug delivery device is provided that comprises a biodegradable scaffold carrying one or more anti-cancer therapeutic agents that activate the innate immune system (e.g., STING agonists) and / or the adaptive immune system (e.g., anti-PD-1 antibodies). The compositions and devices may include a cytokine (e.g., IL- 15 superagonist). The drug delivery device can be implanted in the void volume of a resected tumor to prevent tumor regrowth and tumor metastasis. Also provided are methods of making the drug delivery compositions and devices as well as kits containing materials to provide the compositions and devices.

Simulated tissue structures for practicing surgical techniques and methods of manufacturing those structures are provided. In particular, a realistic organ model or simulated tissue portion for practicing the removal of a tumor or other undesired tissue followed by suturing a remnant defect as part of the same surgical procedure is provided. The simulated tissue structures include a polyp simulation having a suturable mesh layer that is separable from a defect layer. A simulated colon model with interchangeable and suturable tissue pods is also provided as is a fully suturable rectum model and a rectum model with integrative suturable and removable polyp zones.

The invention discloses a polypeptide probe for specifically targeting ACSL4 protein. According to the present invention, the disulfide bond is used to construct the cyclized ACSL4 targeting peptide and is connected with the IR Dye 800CW fluorescent molecule to construct the hepatocellular carcinoma specific targeting probe, and the hepatocellular carcinoma specific targeting probe is used for accurately identifying and positioning the cancer tissue during the liver resection so as to help the surgeon to accurately resection the tumor and maximally retain the normal liver tissue; according to the probe, azide groups are introduced into polypeptide to react with fluorescent molecules (IRDee800-DBCO) modified by DBCO groups, so that the structure of the probe has good stability, and the probe can be specifically combined with ACSL4 protein molecules, so that the probe can specifically target hepatocellular carcinoma; animal in-vivo experiments prove that the probe is high in hepatocellular carcinoma targeting specificity and low in background signal; the compound has a long residence time in tumor tissues, can stably display tumor boundaries without diffusion, has no toxic or side effect, and has a good application prospect.

The application relates to an external mirror system and method for fluorescence imaging, and relates to the technical field of image processing.The system can detect fluorescence under white light operation conditions in the process of tumor resection, and does not need to image in a dark or dim operating room; white light in fluorescence is separated, and a clear fluorescence image is presented; in addition, the fluorescence image can be displayed in 3D, and the display is more intuitive. Through the application, the technical problems of poor darkness, poor definition and complex development process operation in the prior art are solved.

The utility model discloses a tumor edge accurate measuring and marking instrument for breast cancer breast conserving surgery, which belongs to the technical field of medical instruments and comprises a positioning component for positioning the center of a tumor, a circular protractor for indicating the direction of the outer edge of the tumor and a scale for measuring the distance between a marking point and the center of the tumor. The circular protractor is horizontally arranged and fixedly arranged on the positioning component in a sleeving mode, one end of the ruler is rotatably arranged on the positioning component in a sleeving mode, the length direction of the ruler is located in the radial direction of the circular protractor, and the marking piece is connected to the ruler in a sliding mode through a sliding mechanism. And the moving direction of the marking piece is the length direction of the scale. The tumor resection device can be suitable for accurately positioning the edge of a tumor, so that the tumor can be accurately resected, the resection range is not too small to cause tumor residue, and the normal tissue is not excessively resected due to the too large resection range.