Near-infrared-light-sensitive ZIF8 functionalized gelatin nanofiber scaffold system and application thereof

A technology of nanofibers and near-infrared light, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as damage to normal tissues and inability to completely remove tumor cells

Active Publication Date: 2021-11-30
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods have certain limitations
For example, in many cases, surgery cannot completely remove tumor cells, and chemotherapy and radiotherapy can also cause many side effects on the body, such as common nausea and vomiting, and even damage normal tissues

Method used

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  • Near-infrared-light-sensitive ZIF8 functionalized gelatin nanofiber scaffold system and application thereof
  • Near-infrared-light-sensitive ZIF8 functionalized gelatin nanofiber scaffold system and application thereof
  • Near-infrared-light-sensitive ZIF8 functionalized gelatin nanofiber scaffold system and application thereof

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specific Embodiment

[0033] 1. Synthesis and characterization of gelatin scaffold (GF)

[0034] Synthesis method: Weigh 1 g of gelatin and dissolve it in 10 mL of absolute ethanol / PBS (50:50 v / v) solution to prepare a 10 wt% gelatin solution, stir at 60°C for 1 h to fully dissolve the gelatin, Add 1 g of paraffin microspheres with a particle size of 150–300 μm into the vinyl fluoride bottle, and place the mold at 37 °C for 40 min to ensure that the paraffin microspheres can be connected to each other. Then, the gelatin solution (1 mL) cooled to 37°C was dropped onto the paraffin microsphere assembly, and transferred to a -80°C freezer for phase separation overnight. Subsequently, the gelatin / paraffin composite was soaked in ethanol at -20°C for 24 hours, then transferred to 1,4-dioxane for 24 hours and lyophilized at low temperature for 48 hours. Shake in alkane for 4 days, dewax, then shake with cyclohexane for 2 days, replace n-hexane, and then freeze-dry at low temperature for 48 hours. Chemi...

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Abstract

The invention belongs to the field of tissue engineering scaffold materials and particularly relates to a near-infrared-light-sensitive ZIF8 functionalized gelatin nanofiber scaffold system and application thereof. The ZIF8 functionalized gelatin nanofiber scaffold system comprises a gelatin nanofiber scaffold and ZIF8 nanoparticles which are adsorbed onto the gelatin nanofiber scaffold and are subjected to calcination treatment. The invention finds that the ZIF8 nanoparticles have near-infrared-light-sensitive characteristics after being calcined, and can kill tumor cells under the action of near-infrared light stress. The ZIF8 functionalized gelatin nanofiber scaffold system disclosed by the invention is implanted into a defect part after bone tumor excision, and under the action of NIR, a temperature of a GF/ZIF8-phenamil scaffold is increased, so that residual tumor cells are killed. In practical application, in-situ transplantation can be adopted, the requirements of residual tumor cells and bone defect generation after tumor tissue excision can be met, and a new choice is provided for clinical bone tumor treatment.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffold materials, in particular to a near-infrared photosensitive ZIF8 functionalized gelatin nanofiber scaffold system and its application. Background technique [0002] Cancer is an extremely complex disease that threatens human health. However, current cancer diagnosis methods are complicated and effective treatment techniques are lacking. Conventional treatment mainly includes surgery, radiotherapy and chemotherapy. However, these methods have certain limitations. For example, surgery cannot completely remove tumor cells in many cases, and chemotherapy and radiotherapy can also cause many side effects on the body, such as common nausea and vomiting, and even damage normal tissues. [0003] Although the proportion of primary bone tumors is small, bone is one of the most common organs for metastatic tumors. Pathological fractures, bone defects, and spinal cord and nerve root compression a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/18A61L27/54B82Y5/00B82Y40/00
CPCA61L27/222A61L27/18A61L27/54B82Y5/00B82Y40/00A61L2300/216A61L2300/416A61L2430/02A61L2400/12C08L89/00C08L87/00Y02A50/30
Inventor 姚清清潘怡宁李怡佳
Owner WENZHOU MEDICAL UNIV
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