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Drug delivery devices and systems for local drug delivery to the upper urinary tract

A technology for delivering devices and drugs, which can be used in drug delivery, drug devices, drug formulations, etc., and can solve problems such as invasiveness

Pending Publication Date: 2021-06-15
TARIS BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Currently available drug delivery device based treatments are invasive and / or only capable of delivering drug when a delivery catheter is extended from outside the body into the patient

Method used

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  • Drug delivery devices and systems for local drug delivery to the upper urinary tract
  • Drug delivery devices and systems for local drug delivery to the upper urinary tract
  • Drug delivery devices and systems for local drug delivery to the upper urinary tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0186] Example 1 - Drug Delivery Device

[0187] Preparation of gemcitabine release devices for in vitro testing. Use bi-material polyurethane tubing to construct the system. The inner cavity of the drug reservoir of the drug delivery device of this embodiment contains a gemcitabine hydrochloride powder blend, which includes gemcitabine hydrochloride, 30 polyvinylpyrrolidone (PVP) (BASF Corp., USA) and Fumed silica (Cabot Corp., USA).

[0188] The drug delivery device has a dual lumen structure comprising a substantially circular guidewire lumen and a drug reservoir lumen having a crescent cross-sectional shape such as Figure 1C Lumen of drug reservoir shown. The elastic body of the device is made of barium sulfate loaded tecoflex polyurethane (TECOFLEX TM EG-80A-B20, 20% tecoflex polyurethane loaded with barium sulfate (Lubrizol Life Sciences, USA)) and TECOPHILIC TM Made of TPU polyurethane (HP-60D-35 (Lubrizol Life Sciences, USA)). tecoflex polyurethane is a w...

Embodiment 2

[0194] Example 2 - In Vivo Testing of Drug Delivery Devices

[0195] An in vivo test was used to evaluate the migration of two drug delivery devices with different retention shapes.

[0196] A single coil design (e.g., figure 2 of those) deployed into the poles of the renal pelvis of the kidneys of domestic Yorkshire pigs. Upon necropsy, the drug delivery devices were found to migrate, and smaller drug delivery devices were found to be more prone to migration than larger drug delivery devices. Additionally, the length of the single coil drug delivery device is relatively short in order to fit in the available renal pelvis space for the limited drug payload.

[0197] Single coil drug delivery devices were placed in the upper and lower poles of four kidneys of four domestic Yorkshire pigs. Two small (i.e., 4 cm) single coil drug delivery devices were deployed in two animals for 10 days (total of four small drug delivery devices), and two large (i.e., 6 cm) were deployed in...

Embodiment 3

[0202] Example 3 - Drug Delivery Device Shape Changes

[0203] prepared as Image 6 A drug delivery device is shown wherein the helical portion has three turns and the straight end extends generally perpendicular to the helical portion of the device. The straight ends are shaped by heat setting and aligned diagonally across the device. The outer diameter of the coil is 12mm.

[0204] prepared as Figure 7 Drug delivery device shown where the helical portion has six turns and the straight end is formed by heat setting. The outer diameter of the coil of the device is 8 mm. The uncoiled length of the device was 120 mm.

[0205] prepared as Figure 8 Drug delivery device shown with three coils spaced apart by two straight mid-sections. The uncoiled length of the device was 85mm.

[0206] prepared as Figure 9 Drug delivery device shown with two coils separated by a single straight middle section. The uncoiled length of the device was 75mm.

[0207] A drug delivery dev...

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Abstract

Drug delivery devices and systems, are provided for delivery of a drug into the upper urinary tract of patients in need thereof. The drug delivery devices (100) may be deployed directly into the renal pelvis via a patient's ureter, bladder, and urethra, and the drug delivery devices can be wholly retained therein for local continuous, controlled release of a drug over an extended period.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to U.S. Provisional Patent Application 62 / 757,798, filed November 9, 2018, which is incorporated herein by reference. technical field [0003] The present disclosure relates generally to drug delivery devices deployable in vivo for locally controlled delivery of therapeutic and prophylactic agents to the upper urinary tract of patients in need thereof, and more particularly to drug delivery devices for use over extended periods of time A drug delivery device and method for locally administering a drug into the renal pelvis of a patient. Background technique [0004] Implantable drug delivery devices are known for targeted (eg, local or regional) drug delivery in order to avoid one or more problems associated with systemic drug delivery. However, targeted drug delivery to some tissue sites has significant room for improvement. Such sites include the kidneys and ureters....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61K9/00
CPCA61M2210/1082A61M31/002A61M25/0102A61M25/0108A61M25/04A61M25/0026A61B17/225A61M25/0045A61M25/005A61M25/09A61M2025/091A61M2210/1085A61M2210/1089
Inventor E·阿巴特K·丹尼尔J·考尔金斯H·L·何杜克E·格里纳韦
Owner TARIS BIOMEDICAL
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