35 results about "Calcium oxalate calculus" patented technology

In an embodiment of the present disclosure, there is provided a composition for dissolving calcium oxalate crystals thereby inhibiting/preventing further growth of crystals. In some embodiments, such a composition comprises at least one stereoisomer of hydroxycitrate, a derivative of the organic acid citrate. Such a method comprises administering to the subject an effective amount of the aforementioned composition. In another embodiment, the present disclosure pertains to a method of treating kidney stone disorder. Such a method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition. In yet another embodiment, the present disclosure relates to a method of treating calcium oxalate stone disease. In an embodiment, the method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition.

The invention discloses calcium oxalate crystallization inhibitor and application thereof. The inhibitor is prepared by nano selenium which is obtained by mixed reaction of selenite solution and vitamin C solution according to certain proportion. Preferably, the selenite is sodium selenite or selenium dioxide, and the vitamin C is reduced vitamin C. The invention uses the nano selenium to prepare the calcium oxalate crystallization inhibitor for the first time; and the obtained inhibitor can effectively inhibit growth and gather of calcium oxalate, and can be used for preparing calculus inhibiting medicament of the calcium oxalate.

The invention provides an application of hydrogen to preparation of a medicament and a health-care beverage for preventing kidney stones. Hydrogen is prepared into an oral preparation or beverage; after the oral preparation or the beverage is taken, oxalic acid output can be effectively lowered, and urine citric acid concentration is increased; and meanwhile, SOD (Super Oxygen Dehydrogenises) activity can be increased, the generation of MDA (Methane Dicarboxylic Aldehyde) and formation of calcium oxalate stones are reduced, and the reoccurrence of calcium oxalate stones is prevented.

The invention discloses a preparation method of dry powder and fungus powder containing Tricholoma lobayense Heim oxalate decarboxylase and relates to the field of degradation of oxalate in stomachs and intestines of human bodies or animal bodies. The preparation method comprises the following steps of: using Tricholoma lobayense Heim or sibling fungi thereof as raw materials, culturing thalli by adopting a liquid fermentation method, regulating pH (potential of hydrogen) of fermentation solution to 2.0-5.0, inducing to produce oxalate decarboxylase, collection the fermentation solution and the thalli, crushing the thalli, conducting solid-liquid separation to respectively obtain liquid and solid containing the Tricholoma lobayense Heim oxalate decarboxylase, and respectively drying the obtained liquid and solid after separation to obtain the dry powder and the fungus powder containing the Tricholoma lobayense Heim oxalate decarboxylase. The dry powder and the fungus powder containing the Tricholoma lobayense Heim oxalate decarboxylase can be used for oxalic acid removal of food, beverage, feed and the like, can also be used as raw materials to prepare healthcare products or medicines, is suitable for oral taking, can effectively degrade oxalic acid and oxalate and can prevent or cure urine oxalic acid excess symptoms and calcium oxalate calculi.

The invention relates to a composition for inhibiting or dissolving calcium oxalate stones as well as a preparation method and application of the composition. The composition comprises an immobilizedoxalate decarboxylase that can catalyze a decarboxylation reaction of oxalic acid or/and an oxalate, and the immobilized oxalate decarboxylase is prepared by immobilizing oxalate decarboxylase on a magnetic particle carrier. The composition provided by the invention has the function of inhibiting the growth of the calcium oxalate stones or dissolving the calcium oxalate stones, and has the advantages of mildness, good tolerance and high safety, and a patient has no trauma or pain when the composition is applied to treat kidney stones; and when the composition provided by the invention is applied to treat the calcium oxalate stones, the oxalate decarboxylase can be fixed in a renal pelvis by applying a magnetic field to continuously degrade oxalic acid in urine, so that the action time andefficiency of enzyme are increased, after the treatment is completed, the magnetic field is removed, and immobilized enzyme magnetic beads can be excreted with the urine; and after the composition isused in combination with drugs for regulating the pH of the urine, the effects of degrading the oxalic acid and dissolving the stones can be enhanced.

The invention discloses an oxalate-degrading strain NJODE1 and application thereof. The oxalate-degrading strain NJODE1 has a classification name of Enterococcus faecium with the preservation number of CGMCC NO. 4581. The oxalate-degrading strain NJODE1 has good tolerance to acids and bile salts, has no antibiotic resistance to most non-antibiotics, is safe for mice and can be colonized in dogs. The NJODE1 can reduce gastrointestinal absorption of oxalate in foods, thereby reducing the content of oxalate in urine, and thus reducing the incidence of canine calcium oxalate calculus. Whether thefinished product of the strain is food or pharmaceutical products or yogurt and fermented milk, the strain has good resistance to acids and bile salts, contains safe enterococci, and has significant effects on lowering the urinary oxalate content and preventing and treating calcium oxalate calculus of pets, thus having broad application prospects.

The invention relates to the technical field of pet feed, in particular to a prescription diet for calcium oxalate calculus of dogs. The dog food mainly comprises the following raw materials in partsby weight: 70-90 parts of corn, 15-25 parts of beef, 10-15 parts of fish, 10-20 parts of duck, 5-10 parts of dried cranberries, 2-3 parts of poria cocos, 3-5 parts of semen plantaginis, 5-10 parts ofchicken oil, 5-10 parts of peanut oil, 1-2 parts of premixes and 1-5 parts of salt. The dog food provided by the invention is characterized in that the beef, the fish and the duck, which are rich in trace element, are added into the raw materials, and diuretic traditional Chinese medicinal materials such as the poria cocos and the semen plantaginis are also added; through increase of the amount ofurine of the pet dogs, the concentration of oxalic acid in the urine is reduced, and small calcium oxalate crystals are carried out of the bodies to prevent retention of the calcium oxalate calculusin the bodies.

The invention provides a composition for preventing urinary stone. The composition comprises 1wt% or more of a prune juice. The composition can be used as a health food or a health drug and can also comprise pharmaceutically or bromatologically acceptable carriers. The composition comprises prune juice ingredients as effective ingredients such as neochlorogenic acid, chlorogenic acid, caffeoylquinic acid, procyanidin oligomer, a flavonoid compound and rutin. An experiment proves that the prune juice has effects of preventing calcium oxalate calculus of kidney and provides a safe and effective prevention product with a simple source and a low price for kidney calcium oxalate calculus invalidous, subhealth people and health people.

The invention relates to application of yoghourt in the field of preventing urinary calculus. Lactobacillus in the yoghourt has the effect of resolving oxalic acid, can degrade food-borne oxalic acid in intestinal tract, and reduce absorptive amount of the intestinal tract to the oxalic acid, so the yoghourt has the efficacy of preventing urinary calculus of the oxalic acid; and the yoghourt has important application in the fields of medicines, foods and health products. Through animal experiments, the invention provides that urinary oxalate excretion can be effectively reduced by drinking commercial yoghourt, thereby exploring a practical approach in preventing relapse of oxalate calcium calculus. The yoghourt has a plurality of obvious characteristics in health-care function and medicine-food homologization, and has the advantages of low cost, convenient taking and high compliance degree compared with a patient taking drugs, and does not have any side effect, so the yoghourt has better potential of prevention use.

The invention provides an oral composition for dissolving calcium oxalate calculus. The composition contains 0.1-10% of garcinia cambogia extract microcapsules or 0.1-10% of hydroxycitric acid or hydroxycitric acid derivative microcapsules. The composition contains garcinia cambogia extract microcapsules, hydroxycitric acid or hydroxycitric acid derivative microcapsules, so that calculus formed bycalcium oxalate crystals can be effectively dissolved; the materials of the garcinia cambogia extract microcapsules, hydroxycitric acid or hydroxycitric acid derivative microcapsules adopt organic polymer materials, which have certain dissolvability and are capable of conveniently controlling disintegration and dissolution time of the composition and protecting effective components in the composition to reach efficient absorption parts. The composition adopts natural extracts, is free of toxic and side effects on human body and excellent in calculus dissolving effect, can be orally taken by broad crowds, is free of strict restrictions on the crowds, and has broad application prospects.

The invention relates to application of edible lactobacillus in the prevention of urinary calculi. Lactobacillus has the effect of decomposing oxalic acid, can degrade food-borne oxalic acid in an intestinal tract, and reduce the absorption capacity of the intestinal tract to the oxalic acid, so the lactobacillus has the efficacy of preventing calcium oxalate urinary calculi and also has important application in the fields of medicine, food and health care products. The invention proposes that the edible lactobacillus can effectively reduce the excretion of urinary oxalic acid through an animal experiment, and explore a practical way for preventing the recurrence of calcium oxalate calculi. Yoghurt which is taken as a main source of the edible lactobacillus synchronously has various remarkable health care functions and the characteristic of homology of medicine and food, and has the advantages of low cost, convenient eating, and high compliance compared with drug patients. At the same time, the yoghurt also has no any side effect and has better prevention use potential.

Methods of analyzing a biological sample obtained from the feline subject for the presence of two copies of major allele G of SNP A1_212891692 and/or to the concentration of betaine and/or 2-oxoarginine in the sample are disclosed. The methods are used in methods to identify a feline subject that would benefit from a treatment that reduces risk of calcium oxalate stone formation and in methods of treating a feline subject to reduce risk of calcium oxalate stone formation The treatment on comprises administering to the feline subject a composition that comprises an effective amount of one or more of ingredients selected from the group consisting of betaine, green tea, fenugreek and tulsi. Feline food composition that comprise effective amounts of betaine, green tea, fenugreek and tulsi are disclosed.

The invention relates to a method for quickly detecting and analyzing components of canine cat urinary calculi, which is characterized in that a simple quick qualitative chemical analysis method is used for determining the components of the canine cat urinary calculi. The method comprises the following steps: 1, preparing various reagents used for quickly analyzing the components of the canine caturinary calculi; 2, cleaning a collected calculi sample, drying the calculi sample at the room temperature, grinding the calculi sample into powder in a mortar, then taking 20 to 50 milligrams of thecalculi powder and averagely putting the calculi powder into 5 glass tubes to test the components of carbonate, phosphate, uric acid, calcium and ammonium contained in the canine cat urinary calculi;and 3, analyzing and determining the test result: determining the components of the calculi according to whether the tested ions are positive, wherein when the phosphate, the ammonium and magnesium in the calculi sample are positive, the calculi is determined as magnesium ammonium phosphate calculi; and if when the oxalate and the calcium are positive, the calculi is determined as calcium oxalatecalculi. The method is scientific, reasonable, simple in operation, quick in detection and analysis, high in efficiency and low in cost, and provides a precondition for the effective prevention and treatment of canine cat urolithiasis.

Methods of analyzing a biological sample obtained from the feline subject for the presence of one or two copies of minor allele A of SNP A1_212891692 and/or to the concentration of beta-amino isobutyrate and/or 2-oxoarginine concentrations in the sample are disclosed. The methods are used in methods to identify a feline subject that has an increased likelihood or risk of calcium oxalate stone formation and in methods of treating a feline subject to reduce risk of calcium oxalate stone formation. The treatment on comprises administering to the feline subject a low arginine diet. Low arginine feline food compositions are disclosed.

Disclosed are methods of analyzing the presence of one or two copies of the minor allele A of SNP A 1212891692 in a biological sample obtained from a feline subject and/or the concentration of beta-aminoisobutyrate and/or 2-oxoarginine in said sample. The methods can be used in methods for identifying feline subjects with an increased likelihood or risk of calcium oxalate calculus formation and methods for treating feline subjects to reduce the risk of calcium oxalate calculus formation. The treatment comprises administering a low arginine diet to the feline subject. A low arginine feline food composition is disclosed.

The invention relates to an additive for improving urinary tract calculi of pets as well as a preparation method and application of the additive. Urinary tract health functional substances such as fructus arctii, medium-chain fatty acid, citric acid and lactic acid are prepared into the additive, the additive is anti-inflammatory and diuretic, the PH value of urine is reduced to promote dissolution of dog struvite, and formation of pet struvite and calcium oxalate calculi is reduced. The additive can be added to the pet daily ration in the form of a functional bag, and only 1-2% of the additive needs to be added to the pet daily ration, so that the effect of remarkably improving and preventing the conditions of struvite and calcium oxalate calculi of pets can be achieved.

The invention relates to the field of biological medicines, and discloses application of a mechanism of BMP2 silencing in elimination of renal calcium oxalate calculus injuries, and the mechanism is as follows: CaOx crystal deposition and renal cell injuries are reduced by inhibiting oxidative stress reaction through BMP2 silencing. The invention proves that the BMP2 silencing can alleviate sodium oxalate-induced cell oxidative stress and crystallization, and can inhibit phosphorylation of Smad1 and expression of NOX2 and NOX4, proves that the BMP2 silencing can reduce CaOx crystal deposition and renal cell injuries by inhibiting the oxidative stress reaction, and shows that the BMP2 silencing can eliminate the renal tubular epithelial cell oxidative stress injuries. A new direction is indicated for the pathogenesis research of the calcium oxalate calculus .

The invention relates to an artificial calculus preparation method, which is required by the efficacy detection of extra-corporeal lithotriptor with ultrasonic shock-waves. The invention comprises the steps: fixing two templates on a bottom plate to form a mould; selecting 80-90 wt% of calcium sulfate hexahydrate and 15-5 wt% of polyacrylamide of which the consistence is 0.1%; quickly and evenly stirring; putting into the mould; striking off size extruding out of aperture by a plastic plate, and naturally drying in the air; solidifying, removing nuts, separating a model calculus mould, and taking out the model calculus. The invention overcomes the defects that the existing artificial calculus has atypical physical property, or physical property is similar to natural calculus, the preparation method is too complex, cost is high and the like. The physical property of the artificial calculus prepared by the invention is similar to whewellite calculus, can obtain vivid detection data and is favourable for accurately evaluating efficacy situation thereof, and the method is simple and convenient.