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Control of acidosis

a technology of acidosis and acidosis, applied in the field of acidosis control, can solve the problems of reducing the risk of acidosis, reducing the risk of feed intake and weight gain

Inactive Publication Date: 2006-03-14
SPRUSON & FERGUSON +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0036]Typically, the vaccine or pharmaceutical composition administered in accordance with the third, fourth or fifth embodiments of the invention, may also be simultaneously or sequentially administered with cytokines, such as: G-CSF, GM-CSF, interleukins or tumour necrosis factor. Cytokines can also be combined with adjuvants to enhance the immune response.
[0085]Typically, a combination of immunisation / active agent treatment, allows the control harmful lactic acid producing bacteria and thus allowing the better establishment of favourable starch utilising organisms. The effect of this combination of treatment is synergistic and not merely additive.

Problems solved by technology

The conditions of acidosis can be acute, posing an immediate life-threatening situation, or chronic (sub-acute), resulting in reduction in both feed intake and weight gain.
However, under certain feeding conditions addition of virginiamycin has not always reduced the risk of acidosis (Godfrey et al., 1995; Courtney and Seirer, 1996; Thomiley et al., 1998).

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Control of S. ruminantium, Clostridium-like vitulinus, S. bovis and S. equinus

Material and Methods

Isolation, Identification and characterisation of lactic acid producing bacteria

[0250]The following method was used to isolate the most numerous and most prolific acid-producing bacteria in the gut contents of ruminant and non-ruminant animals. Rumen fluid samples were obtained via stomach tube from sheep and via rumen fistula from cattle 24 h after regular grain feeding. Faecal samples were obtained directly from the rectum of sheep and cattle and from the freshly voided faeces from horses. Samples were processed for the enumeration of lactic acid bacteria following the method of Yanke and Cheng (1998) involving one-hour exposure prior to incubation. A semi-selective MRS-agar medium, Oxoid, England (De Man et al. 1960) was modified by adding a freshly prepared reducing solution (1 ml containing 0.02 g Cysteine, HCl and 0.026 g of Na2S.9H2S.9H2O per 100 ml of media) after boiling then ...

example 2

[0269]Samples of faceces were collected from 12 horses fed a mixture of chopped leucerne hay and different types of cereal grain (oats, barley, triticale and sorghum). The dominant lactic acid producing bacteria were isolated using the same method as described in Example 1. Two bacteria were isolated: Streptococcus bovis (SbR1) and Streptococcus equinus (SER1 and SER2). Based on these results it is important that any vaccine, diagnosis or other treatment to prevent or control acidosis should be effective against both S. bovis and S. equinus. Under some conditions it will also be necessary for these diagnostic tools and methods of treatment to be effective against S. ruminantium, Clostridium-like vitulinus as well as S. bovis and S. equinus.

[0270]In certain conditions it is likely that Selenomonas ruminantium and Clostridium-like vitulinus bacteria may be present and in this case animals should be vaccinated against both Gram-positive and Gram-negative lactic acid producing bacteria...

example 3

[0271]Following calving, cows grazing lush green pasture are exposed to high levels of soluble carbohydrate in the form of fructans in grasses and sugars and starch in clovers. In addition to fermentable carbohydrates in the pasture, concentrate feed supplements, based on cereal grain, are fed twice daily during milking. The fructants in pastures and the starch in legumes and concentrate are rapidly fermented in either the rumen or the hind gut to form a range of volatile fatty acids and lactic acid. The accumulation of acids in the gut contribute to the metabolic acid load of the animal, can cause inflammation of the gut wall leading to stimulation of the immune system and can lead to increased pathogenicity in the populations of bacteria and parasites within the gut. The adverse effects of acid accumulation in the gut result in reduced productivity and an increased incidences of disease including lameness, respiratory conditions and mastitis.

[0272]Acid accumulation in the gut unde...

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Abstract

The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof, wherein said microorganism is capable of producing lactic acid within the gut of said vertebrate, and wherein said microorganism is selected from the group consisting of: Clostridium-like species, Prevotella-like species, Bacteroides-like species, Enterococcus-like species, Selenomonas species, non-dextran slime producing Streptococcus species and non-slime producing lactic acid bacterial isolates.

Description

TECHNICAL FIELD[0001]The present invention relates to the identification of a series of microorganisms involved in the development of acidosis, together with the treatment and / or prevention and / or detection of acidosis in vertebrates, in particular, vaccines, compositions and methods for the treatment and / or prevention and / or detection of acidosis in vertebrates.BACKGROUND ART[0002]The over production of acid in the gut of an animal by microorganisms can cause fermentative acidosis, wherein is defined as a condition of abnormally high acidity in the gut that can lead to local and systemic acidosis, damage to the integrity of the gut wall and increased pathogenicity of gut bacteria and parasites.[0003]The introduction of starch, sugars or oligosaccharides into the rumen of ruminant animals and the hind gut (caecum and colon) of ruminant and non-ruminant animals including humans, leads to rapid fermentation and production of volatile fatty acids (VFA). As the rate of VFA production ex...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K38/16A61K31/70A61K38/00A61K35/74A61K39/08A61P1/04C07K14/195C07K14/315
CPCA61K35/74A61K35/741A61K38/488A61K38/47C07K16/1267G01N33/56944G01N33/56911C12R1/46C12R1/01C12Q1/025C07K14/315A61K35/744A61K38/19A61K39/0216A61K39/08A61K39/092A61K45/06C07K14/195Y10S435/853G01N2333/335A61K2039/52A61K2300/00A61P1/04C12R2001/01C12N1/205C12R2001/46
Inventor ROWE, JAMES BARBERAL JASSIM, RAFAT A M
Owner SPRUSON & FERGUSON
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