Technique for preparing malonyl ginsenoside, and application of medication in treating diabetes

A technology of malonyl ginsenosides and ginsenosides, which can be used in drug combinations, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as the loss of water-soluble saponins.
CN1696144AInactive Publication Date: 2005-11-16JILIN AGRICULTURAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
JILIN AGRICULTURAL UNIV
Publication Date
2005-11-16
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

A process for preparing the malonyl ginsenoside used to prepare the medicine for treating diabetes includes pulverizing fresh ginseng, immersing in alcohol for extracting, vacuum recovering of solvent, concentrating to become aqueous solution, repeated extraction by n-butanol and water, concentrating, adsorbing by macroreticular resin column, eluting with alcohol, and recovering alcohol. A monoacyl arasaponin-R4 malonate and its medical application are also disclosed.
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Description

technical field

[0001] The present invention relates to medicines for treating diabetes, and in particular discloses a preparation process of malonyl ginsenoside and its medicinal use for treating diabetes, and also provides a new malonyl ginsenoside-R4 compound and its medical application The use belongs to the technical field of traditional Chinese medicine. Background technique

[0002] Malonyl ginsenosides (Malonyl-ginsenosides) involved in the present invention are also called malonyl ginsenosides, mainly including M-Rb 1 , M-Rb 2 , M-Rc, M-Rd and M-NR4 series compounds.

[0003] At present, in the commercial production of malonyl ginsenosides, when the total saponins are extracted with n-butanol, these saponins are easily miscible in the water layer and are removed as water-soluble impurities such as sugar and inorganic salts; the total saponins When the extract is directly applied to the macroporous resin column, part of the water-soluble saponins will also be lost...

Claims

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