Composition for assisting in reducing blood sugar and improving insulin resistance and preparation method thereof

Abstract

The invention provides a composition for assisting in reducing blood sugar and improving insulin resistance and a preparation method of the composition, and relates to the technical field of functional fiber processing. The composition for assisting in reducing blood sugar and improving insulin resistance comprises the following raw materials in parts by weight: 10-15 parts of depolymerization type composite cereal fibers, 3-5 parts of konjac fibers, 3-5 parts of psyllium husk powder, 2-3 parts of sesame powder, 1-2 parts of xylitol and 0.1-0.5 part of vitamin C, the mass ratio of wheat fiber to corn fiber to sweet potato fiber to pea fiber in the depolymerization type composite grain fiber is (25-30): (35-40): (20-25): (10-15). The composition disclosed by the invention can assist in reducing blood sugar and has a good effect of improving insulin resistance.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of functional fiber processing technology, in particular to a composition for assisting in reducing blood glucose and improving insulin resistance and a preparation method thereof. BACKGROUND

[0002] The efficiency of insulin in lowering blood glucose begins to decrease, which is called insulin resistance. Ten years before the diagnosis of diabetes, insulin sensitivity continues to decrease, and insulin resistance gradually appears, which is the key stage of disease development. The key to reversing the progression of diabetes is to reduce insulin resistance.

[0003] Compared with other methods of reducing blood glucose, reducing insulin resistance has the following advantages: (1) better blood glucose control effect can be achieved without changing the drug and dietary habits; (2) restoring the ability of cells to store glycogen, maintaining stable blood glucose, and reducing glycosylated hemoglobin; (3) reducing the level of body inflammation and delaying the development of diabetic complications (such as diabetic foot and diabetic nephropathy).

[0004] Nature Medicine points out that the number of diabetes patients will continue to rise if the dietary structure is not improved. In 2018, 70% of the newly diagnosed diabetes cases worldwide were related to poor diet, and the proportion of factors related to insufficient cereal fiber was more than 50%. SUMMARY

[0005] In view of this, the present application provides a composition for assisting in reducing blood glucose and improving insulin resistance and a preparation method thereof, which can assist in reducing blood glucose and improving insulin resistance.

[0006] The technical solution of the present application is as follows: A composition for assisting in reducing blood glucose and improving insulin resistance, comprising the following raw materials in parts by weight: 10-15 parts of depolymerized composite cereal fiber, 3-5 parts of konjac fiber, 3-5 parts of psyllium husk powder, 2-3 parts of sesame powder, 1-2 parts of xylitol, and 0.1-0.5 parts of vitamin C; the mass ratio of wheat fiber, corn fiber, sweet potato fiber, and pea fiber in the depolymerized composite cereal fiber is 25-30:35-40:20-25:10-15.

[0007] Preferably, the mass ratio of wheat fiber, corn fiber, sweet potato fiber, and pea fiber in the depolymerized composite cereal fiber is 28:37:22:13.

[0008] Preferably, the composition comprises the following raw materials in parts by weight: 12 parts of depolymerized composite cereal fiber, 4 parts of konjac fiber, 4 parts of psyllium husk powder, 2 parts of sesame, 1.5 parts of xylitol, and 0.3 parts of vitamin C.

[0009] Preferably, the psyllium husk powder is nano-sized psyllium husk powder with a particle size of 100-200 nm.

[0010] Preferably, the preparation method of the konjac fiber includes the following steps: take konjac powder, add 0.008%-0.012%wt amylase solution at a material-to-liquid ratio of 1:4-6 g / ml for enzymatic hydrolysis for 1-2 hours, filter and centrifuge, and collect the precipitate; add 4-6 times the weight of 0.15%-0.25%wt sodium bicarbonate solution to the precipitate, stir for 10-30 minutes, filter to remove insoluble impurities; dry and grind to obtain the konjac fiber.

[0011] Preferably, the amylase is composed of α-amylase and β-amylase in a mass ratio of 6-8:2-4.

[0012] This invention provides a method for preparing a composition for assisting in lowering blood sugar and improving insulin resistance, comprising the following steps: (1) Grind the sesame powder thoroughly; (2) According to the ingredient ratio, vitamin C, xylitol and psyllium husk powder were premixed to obtain a homogeneous mixture of VC-xylitol-husk powder; (3) According to the ingredient ratio, wheat fiber, corn fiber, sweet potato fiber, pea fiber and konjac fiber are put into a three-dimensional mixer and mixed at 10-20 rpm for 15-25 minutes; then add sesame powder and VC-sugar alcohol-shell powder mixture, increase the speed to 20-30 rpm and mix for 25-35 minutes; reduce the speed to 5-15 rpm and mix for 5-15 minutes to obtain the target mixture.

[0013] Preferably, in step (1), the sesame powder is ground to 100 mesh at a low temperature of 10-20℃.

[0014] Preferably, in step (3), wheat fiber, corn fiber, sweet potato fiber, pea fiber, and konjac fiber are put into a three-dimensional mixer and mixed at 15 rpm for 20 minutes; then sesame powder and VC-sugar alcohol-shell powder mixture are added, and the speed is increased to 25 rpm and mixed for 30 minutes; then the speed is reduced to 10 rpm and mixed for 10 minutes.

[0015] Compared with the prior art, the beneficial effects of the present invention are: (1) The depolymerized composite cereal fiber used in this invention is prepared by combining wheat fiber, corn fiber, sweet potato fiber, pea fiber in a certain ratio with konjac fiber prepared by the process of this invention, and adding nano-sized psyllium husk powder, etc. The prepared composition has a good auxiliary hypoglycemic effect, protects the function of pancreatic β cells, and has a significant effect on improving insulin resistance.

[0016] (2) The application adds a certain proportion of depolymerization type composite cereal fiber of wheat fiber, corn fiber, sweet potato fiber and pea fiber, fully plays a synergistic effect of reducing blood sugar, targets to activate the intestinal-islet axis, reduces endogenous glucose production, delays carbohydrate digestion and absorption, and enhances satiety and energy metabolism.

[0017] (3) The application pre-mixes vitamin C, xylitol and psyllium husk powder to prepare a VC-sugar alcohol-shell powder mixture, better plays a synergistic mechanism between molecules, and further improves the efficiency of the composition.

[0018] (4) The process of the application not only facilitates production and preparation, but also further improves the bioavailability of the composition. DETAILED DESCRIPTION

[0019] The experimental methods used in the embodiments of the application are conventional methods unless otherwise specified. The materials, reagents and the like used in the embodiments of the application can be obtained from commercial channels unless otherwise specified.

[0020] The corn fiber used in the embodiments of the application is corn skin dietary fiber ultrafine powder prepared by the method of CN111194926B embodiment 2.

[0021] The wheat fiber used in the embodiments of the application is prepared by referring to the method of CN111194926B embodiment 2, with wheat hull as the raw material.

[0022] The sweet potato fiber used in the embodiments of the application is prepared by referring to the method of CN111194926B embodiment 2, with sweet potato skin as the raw material.

[0023] The pea fiber used in the embodiments of the application is prepared by referring to the method of CN111194926B embodiment 2, with pea shell as the raw material.

[0024] Embodiment 1 A composition for assisting in reducing blood sugar and improving insulin resistance is prepared from the following raw materials by weight: 10 parts of depolymerization type composite cereal fiber, 5 parts of konjac fiber, 3 parts of psyllium husk powder, 2 parts of sesame powder, 1 part of xylitol, and 0.1 part of vitamin C; the mass ratio of wheat fiber, corn fiber, sweet potato fiber and pea fiber in the depolymerization type composite cereal fiber is 25:35:25:15.

[0025] The preparation process comprises the following steps: (1) Preparation of konjac fiber: konjac powder was added to 0.01%wt amylase solution according to the solid-liquid ratio g / ml of 1:5, wherein the amylase was composed of α-amylase and β-amylase with a mass ratio of 7:3, and was enzymatically hydrolyzed at 55-60°C for 1.5h, filtered and centrifuged, and the precipitate was collected; the precipitate was added to 5 times the weight of 0.2%wt sodium bicarbonate solution, stirred for 15min, filtered, and the insoluble impurities were removed; dried, finely ground to 100 mesh, and obtained, ready for use.

[0026] (2) The round buckwheat shell powder was ground to a particle size of 100-200nm by using a supermicro grinding process to obtain nanoscale round buckwheat shell powder, ready for use.

[0027] (3) The sesame powder was ground at 15°C to 100 mesh, ready for use.

[0028] (4) According to the ingredient ratio, vitamin C, xylitol and round buckwheat shell powder were pre-mixed to obtain a uniform VC-sugar alcohol-shell powder mixture.

[0029] (5) According to the ingredient ratio, wheat fiber, corn fiber, sweet potato fiber, pea fiber and konjac fiber were put into a three-dimensional mixer and mixed at a speed of 15rpm for 20 minutes; then the sesame powder and the VC-sugar alcohol-shell powder mixture were added, the speed was increased to 25rpm and mixed for 30 minutes; the speed was reduced to 10rpm and mixed for 10 minutes; after mixing, the dehumidification system of the mixer was started, and the humidity was ≤45%, to obtain the target mixture, which was packaged, 10g per bag.

[0030] Example 2 A composition for assisting in reducing blood sugar and improving insulin resistance was prepared from the following raw materials by weight: depolymerized composite cereal fiber 15 parts, konjac fiber 3 parts, round buckwheat shell powder 5 parts, sesame powder 3 parts, xylitol 2 parts, vitamin C 0.3 parts; the mass ratio of wheat fiber, corn fiber, sweet potato fiber and pea fiber in the depolymerized composite cereal fiber was 30:40:20:10.

[0031] The preparation process includes the following steps: (1) Preparation of konjac fiber: konjac powder was added to 0.01%wt amylase solution according to the solid-liquid ratio g / ml of 1:5, wherein the amylase was composed of α-amylase and β-amylase with a mass ratio of 7:3, and was enzymatically hydrolyzed at 55-60°C for 1.5h, filtered and centrifuged, and the precipitate was collected; the precipitate was added to 5 times the weight of 0.2%wt sodium bicarbonate solution, stirred for 15min, filtered, and the insoluble impurities were removed; dried, finely ground to 100 mesh, and obtained, ready for use.

[0032] (2) The round buckwheat shell powder was ground to a particle size of 100-200nm by using a supermicro grinding process to obtain nanoscale round buckwheat shell powder, ready for use.

[0033] (3) The sesame powder is fully ground to 100 mesh at 15°C, and is ready for use.

[0034] (4) According to the ingredient ratio, vitamin C, xylitol and psyllium husk powder are fully premixed to obtain a uniform VC-sugar alcohol-husk powder mixture.

[0035] (5) According to the ingredient ratio, wheat fiber, corn fiber, sweet potato fiber, pea fiber and konjac fiber are put into a three-dimensional mixer and mixed at 15 rpm for 20 minutes; then the sesame powder and the VC-sugar alcohol-husk powder mixture are added, and the speed is increased to 25 rpm for mixing for 30 minutes; and then the speed is reduced to 10 rpm for mixing for 10 minutes; after mixing, the dehumidification system of the mixer is started, and the humidity is ≤45%, to obtain the target mixture, which is packaged, 10 g per bag.

[0036] Example 3 A composition for assisting in reducing blood sugar and improving insulin resistance is prepared from the following raw materials by weight: 12 parts of depolymerized composite cereal fiber, 4 parts of konjac fiber, 4 parts of psyllium husk powder, 2 parts of sesame, 1.5 parts of xylitol, and 0.3 parts of vitamin C; the mass ratio of wheat fiber, corn fiber, sweet potato fiber and pea fiber in the depolymerized composite cereal fiber is 28:37:22:13.

[0037] The preparation process includes the following steps: (1) Preparation of konjac fiber: konjac powder is added to a 0.01% wt amylase solution at a material to liquid ratio g / ml of 1:5, wherein the amylase is composed of α-amylase and β-amylase at a mass ratio of 7:3, and is enzymatically degraded at 55-60°C for 1.5 hours, then filtered and centrifuged to collect the precipitate; the precipitate is added to 5 times the weight of a 0.2% wt sodium bicarbonate solution, stirred for 15 minutes, filtered to remove insoluble impurities, dried, and finely ground to 100 mesh to obtain the konjac fiber, which is ready for use.

[0038] (2) The psyllium husk powder is ground to a particle size of 100-200 nm using a supermicro grinding process to obtain nanoscale psyllium husk powder, which is ready for use.

[0039] (3) The sesame powder is fully ground to 100 mesh at 15°C, and is ready for use.

[0040] (4) According to the ingredient ratio, vitamin C, xylitol and psyllium husk powder are fully premixed to obtain a uniform VC-sugar alcohol-husk powder mixture.

[0041] (5) According to the ingredient ratio, the wheat fiber, corn fiber, sweet potato fiber, pea fiber and konjac fiber are put into a three-dimensional mixer, mixed at 15 rpm for 20 minutes; then the sesame powder and the VC-sugar alcohol-shell powder mixture are added, the speed is increased to 25 rpm for mixing for 30 minutes; the speed is decreased to 10 rpm for mixing for 10 minutes, after mixing, the dehumidification system of the mixer is started, the humidity is less than or equal to 45%, the target mixture is obtained, packaged, 10 g per small bag.

[0042] Example 4 A composition for assisting in reducing blood sugar and improving insulin resistance, which is different from example 3 in the preparation process: (1) Preparation of konjac fiber: konjac powder is added to 0.01%wt amylase solution according to the material-liquid ratio g / ml of 1:4, wherein the amylase is composed of α-amylase and β-amylase with a mass ratio of 8:2, and is enzymatically hydrolyzed at 55-60°C for 2h, filtered and centrifuged, and the precipitate is collected; the precipitate is added to 4 times the weight of 0.2%wt sodium bicarbonate solution, stirred for 10 min, filtered, and the insoluble impurities are removed; dried, ground to 100 mesh, and obtained, ready for use.

[0043] (2) The psyllium shell powder is ground to a particle size of 100-200 nm by using a super micro grinding process to obtain a nano-level psyllium shell powder, which is ready for use.

[0044] (3) The sesame powder is ground to 100 mesh at 10°C, and is ready for use.

[0045] (4) According to the ingredient ratio, the vitamin C, xylitol and psyllium shell powder are pre-mixed to obtain a VC-sugar alcohol-shell powder mixture.

[0046] (5) According to the ingredient ratio, the wheat fiber, corn fiber, sweet potato fiber, pea fiber and konjac fiber are put into a three-dimensional mixer, mixed at 10 rpm for 25 minutes; then the sesame powder and the VC-sugar alcohol-shell powder mixture are added, the speed is increased to 20 rpm for mixing for 35 minutes; the speed is decreased to 5 rpm for mixing for 15 minutes, after mixing, the dehumidification system of the mixer is started, the humidity is less than or equal to 45%, the target mixture is obtained, packaged, 10 g per small bag.

[0047] Example 5 A composition for assisting in reducing blood sugar and improving insulin resistance, which is different from example 3 in the preparation process: (1) Preparation of konjac fiber: konjac powder was added to 0.01% wt amylase solution at a solid-liquid ratio of g / ml 1:6, the amylase was composed of α-amylase and β-amylase at a mass ratio of 6:4, and was enzymatically hydrolyzed at 55-60°C for 1 h, then filtered and centrifuged to collect the precipitate; the precipitate was added to 6 times the weight of 0.2% wt sodium bicarbonate solution, stirred for 20 min, filtered to remove insoluble impurities; dried and ground to 100 mesh, and then obtained, ready for use.

[0048] (2) The round buckwheat shell powder was ground to a particle size of 100-200 nm by using a supermicro grinding process to obtain nanoscale round buckwheat shell powder, ready for use.

[0049] (3) The sesame powder was ground to 100 mesh at 20°C, ready for use.

[0050] (4) According to the ingredient ratio, vitamin C, xylitol and round buckwheat shell powder were premixed to obtain a VC-xylitol-shell powder mixture.

[0051] (5) According to the ingredient ratio, wheat fiber, corn fiber, sweet potato fiber, pea fiber and konjac fiber were put into a three-dimensional mixer and mixed at a speed of 20 rpm for 15 minutes; then the sesame powder and the VC-xylitol-shell powder mixture were added, the speed was increased to 30 rpm and mixed for 25 minutes; the speed was reduced to 15 rpm and mixed for 5 minutes; after mixing, the dehumidification system of the mixer was started, and the humidity was ≤45%, to obtain the target mixture, which was packaged at 10 g per bag.

[0052] Comparative Example 1 A composition for assisting in reducing blood sugar and improving insulin resistance, which is different from Example 3 in that the mass ratio of wheat fiber, corn fiber, sweet potato fiber and pea fiber in the depolymerized composite cereal fiber is 1:1:1:1.

[0053] Specifically, the composition is prepared from the following raw materials by weight: 12 parts of depolymerized composite cereal fiber, 4 parts of konjac fiber, 4 parts of round buckwheat shell powder, 2 parts of sesame, 1.5 parts of xylitol and 0.3 parts of vitamin C; the mass ratio of wheat fiber, corn fiber, sweet potato fiber and pea fiber in the depolymerized composite cereal fiber is 25:25:25:25.

[0054] Test Example 1. Animal selection and model induction: healthy adult SD rats (half male and half female) were selected, and after being fed with high-fat diet for 8 weeks, streptozotocin (25 mg / kg) was injected intraperitoneally to induce a type 2 diabetes model.

[0055] 2. Success criteria for modeling: the fasting blood samples of the tail vein were detected for 3 consecutive days, and 16.7 mmol / L was taken as the success criteria for modeling.

[0056] 3. Grouping and intervention: the rats with successful modeling were randomly divided into a model group, research groups 1-9, a positive control group (acarbose), and a healthy group (regular feeding).

[0057] 4. Administration and monitoring The positive control group: acarbose 100 mg / kg was administered once a day; the research groups 1-9: acarbose 100 mg / kg was administered once a day, and the composition of the application or the comparative example 1 g / kg was administered twice a day; the composition was diluted 10 times with warm water before use; the administration method: gavage. The intervention lasted for 2 weeks. The fasting blood glucose (mmol / L) and fasting insulin (μIU / mL) were detected before and after 2 weeks of intervention, respectively. The insulin resistance index was calculated, and the relative reduction percentage of blood glucose was calculated.

[0058] Insulin resistance index = (fasting insulin x fasting blood glucose) / 22.5; Auxiliary hypoglycemic percentage = (blood glucose value of the positive control group - blood glucose value of the research group) / blood glucose value of the positive control group * 100%.

[0059] Table 1 auxiliary hypoglycemic effect comparison

[0060] The results show that compared with the positive control group, the research groups 1-6 all have further auxiliary hypoglycemic effects, among which, the research group 3 (example 3) has the best auxiliary hypoglycemic effect. Compared with the research group 3, the auxiliary hypoglycemic effect of the research group 6 is obviously decreased.

[0061] It can be seen that the ratio of the wheat fiber, corn fiber, sweet potato fiber and pea fiber in the depolymerization type composite cereal fiber has an obvious influence on the auxiliary hypoglycemic effect. The konjac fiber prepared by the process of the application has a better auxiliary hypoglycemic effect. The use of nanoscale psyllium husk powder prepared by the application is also conducive to improving the auxiliary hypoglycemic effect. Compared with the research group 3, the effect of the research group 9 is decreased, the pre-mixing of vitamin C, xylitol and psyllium husk powder in the application to prepare the VC-sugar alcohol-husk powder mixture obviously influences the auxiliary hypoglycemic effect.

[0062] Table 2 comparison of insulin resistance improvement effect

[0063] The results show that compared with the positive control group, the research groups 1-6 all have further obvious insulin resistance improvement effects, among which, the research group 3 (example 3) has the best insulin resistance improvement effect.

[0064] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the application and do not limit the protection scope of the application.

Claims

1. A composition for assisting in reducing blood glucose and improving insulin resistance, characterized by, The raw materials include the following components by weight: depolymerized composite cereal fiber 10-15 parts, konjac fiber 3-5 parts, psyllium husk powder 3-5 parts, sesame powder 2-3 parts, xylitol 1-2 parts, and vitamin C 0.1-0.5 parts; the mass ratio of wheat fiber, corn fiber, sweet potato fiber, and pea fiber in the depolymerized composite cereal fiber is 25-30:35-40:20-25:10-15.

2. The composition of claim 1, wherein, The mass ratio of wheat fiber, corn fiber, sweet potato fiber, and pea fiber in the depolymerized composite cereal fiber is 28:37:22:

13.

3. The composition according to claim 1 or 2, characterized in that, The raw materials include the following components by weight: depolymerized composite cereal fiber 12 parts, konjac fiber 4 parts, psyllium husk powder 4 parts, sesame 2 parts, xylitol 1.5 parts, and vitamin C 0.3 parts.

4. The composition of claim 1, wherein, The psyllium husk powder is nanoscale psyllium husk powder with a particle size of 100-200 nm.

5. The composition of claim 1, wherein, The preparation method of the konjac fiber includes the following steps: taking konjac, adding 0.008%-0.012%wt amylase solution according to a material-liquid ratio g / ml of 1:4-6 for enzymolysis for 1-2 h, filtering and centrifuging, and collecting the precipitate; adding 4-6 times the weight of 0.15%-0.25%wt sodium bicarbonate solution to the precipitate, stirring for 10-30 min, drying, and finely grinding to obtain the konjac fiber.

6. The composition of claim 5, wherein, The amylase is composed of α-amylase and β-amylase in a mass ratio of 6-8:2-4.

7. The method of preparing the composition for aiding in reducing blood glucose and improving insulin resistance according to any one of claims 1 to 6, characterized in that, The method includes the following steps: (1) grinding the sesame powder; (2) pre-mixing vitamin C, xylitol, and psyllium husk powder according to the ingredient ratio to obtain a VC-xylitol-husk powder mixture; (3) putting wheat fiber, corn fiber, sweet potato fiber, pea fiber, and konjac fiber into a three-dimensional mixer according to the ingredient ratio, mixing at a speed of 10-20 rpm for 15-25 min, adding the sesame powder and the VC-xylitol-husk powder mixture, increasing the speed to 20-30 rpm for mixing for 25-35 min, and reducing the speed to 5-15 rpm for mixing for 5-15 min to obtain the target mixture.

8. The method for preparing the composition for assisting in lowering blood glucose and improving insulin resistance according to claim 6, characterized in that, In step (1), the sesame powder is ground at a low temperature to 100 mesh, and the low-temperature grinding temperature is 10-20℃.

9. The method for preparing the composition for assisting in lowering blood glucose and improving insulin resistance according to claim 6, characterized in that, In step (3), the wheat fiber, corn fiber, sweet potato fiber, pea fiber, and konjac fiber are put into a three-dimensional mixer, mixed at a speed of 15 rpm for 20 min, the sesame powder and the VC-xylitol-husk powder mixture are added, the speed is increased to 25 rpm for mixing for 30 min, and the speed is reduced to 10 rpm for mixing for 10 min.

10. A composition for assisting in reducing blood glucose and improving insulin resistance, characterized by, The method is prepared by any one of claims 6-9.

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