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Buccal tablet for reducing blood sugar

A buccal tablet and hypoglycemic technology, which is applied in the field of buccal tablets, can solve problems such as side reactions and drug application restrictions, and achieve the effects of avoiding loss, overcoming drug application restrictions, and improving absorption and utilization

Inactive Publication Date: 2012-06-13
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the conventional drugs for the treatment of diabetes are mainly oral hypoglycemic drugs and long-term use of insulin, but they all have different degrees of side effects, and the application of drugs is limited, which cannot meet the needs of today's fast-paced life and the ever-improving quality of life. It is necessary to look for buccal tablet formulations with long-lasting hypoglycemic effect, low toxicity, convenient administration, storage and portability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] In parts by weight, the unit is kilogram, weighed respectively: 18 parts of Cyclocarya paliurus extract, 17 parts of cinnamon extract, 13 parts of bitter melon extract, 10 parts of taurine, 12 parts of Chinese yam extract, 12 parts of Pueraria root extract , 8 parts of croscarmellose sodium, 3 parts of aspartame, 6.7 parts of magnesium stearate, 0.3 parts of mint essence.

[0020] Wherein: the above-mentioned Cyclocarya paliurus extract is obtained by the following method: take the Cyclocarya paliurus powder that has been dried and sieved, add deionized water in an amount of solid-liquid weight ratio of 1:20, extract with a rotary evaporator for 3 hours, filter, and remove Residue; the filtrate is divided into two parts, one part is extracted with 80% ethanol for 3 hours, and then extracted with water for 4 hours, and the polysaccharide of Cyclocarya paliurus is obtained after using the conventional water extraction and alcohol precipitation method to remove protein with...

Embodiment 2

[0026] In parts by weight, the unit is kilogram, weighed respectively: 16 parts of Cyclocarya paliurus extract, 15 parts of cinnamon extract, 11 parts of bitter melon extract, 8 parts of taurine, 10 parts of yam extract, and 10 parts of Pueraria lobata extract , 5 parts of croscarmellose sodium, 2 parts of aspartame, 6 parts of magnesium stearate, 0.2 part of mint essence.

[0027] Wherein: the above-mentioned Cyclocarya paliurus extract is obtained by the following method: take the Cyclocarya paliurus powder that has been dried and sieved, add deionized water at a solid-to-liquid weight ratio of 1:20, extract with a rotary evaporator for 2 hours, filter, and remove Residue; the filtrate is divided into two parts, one part is extracted with 80% ethanol for 2 hours, and then extracted with water for 3 hours, and the polysaccharide of Cyclocarya paliurus is obtained after using the conventional water extraction and alcohol precipitation method to remove protein with trichloroacet...

Embodiment 3

[0033] In parts by weight, the unit is kilogram, weighed respectively: 20 parts of Cyclocarya paliurus extract, 19 parts of cinnamon extract, 15 parts of bitter melon extract, 12 parts of taurine, 14 parts of Chinese yam extract, 14 parts of Pueraria root extract , 10 parts of croscarmellose sodium, 5 parts of aspartame, 9 parts of magnesium stearate, 0.5 part of peppermint essence.

[0034] Wherein: the above-mentioned Cyclocarya paliurus extract is obtained by the following method: take the Cyclocarya paliurus powder that has been dried and sieved, add deionized water at a solid-to-liquid weight ratio of 1:22, extract with a rotary evaporator for 5 hours, filter, and remove Residue; the filtrate is divided into two parts, one part is extracted with 80% ethanol for 3 hours, and then extracted with water for 4 hours, and the polysaccharide of Cyclocarya paliurus is obtained after using the conventional water extraction and alcohol precipitation method to remove protein with tri...

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Abstract

The invention discloses a buccal tablet for reducing blood sugar, which is prepared by the following ingredients in parts by weight: 16-20 parts of cyclocarya paliurus extractive, 15-19 parts of cinnamon extractive, 11-15 parts of balsam pear extractive, 8-12 parts of taurine, 10-14 parts of Chinese yam extractive, 10-14 parts of kudzu root extractive, 5-10 parts of cross-linking sodium carboxymethylcellulose, 2-5 parts of aspartame, 6-9 parts of magnesium stearate and 0.2-0.5 parts of peppermint essence. The buccal tablet for reducing blood sugar of the invention has the advantages of convenience for taking, easy storage and convenience for carrying, and the bioavailability thereof is greatly improved than that of the common preparation, so that a convenient drug delivery method is provided to adapt for the fast-paced life demands and continuously improved life styles.

Description

technical field [0001] The invention relates to a buccal tablet, in particular to a hypoglycemic buccal tablet. Background technique [0002] According to incomplete statistics, there are about 40 million people with diabetes in my country, and the incidence of diabetes is increasing at a rate of more than 1 million people every year. It has become one of the diseases that seriously threaten the survival and health of human beings. Sustained hyperglycemia can lead to complications in the myocardium, blood vessels, nervous system, kidneys, etc., which are life-threatening. Therefore, control of elevated blood sugar has become the primary goal of the treatment of diabetes. At present, the conventional drugs for the treatment of diabetes are mainly oral hypoglycemic drugs and long-term use of insulin, but they all have different degrees of side effects, and the application of drugs is limited, which cannot meet the needs of today's fast-paced life and the ever-improving qualit...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P3/10A61K31/185
Inventor 张尚立常宏文张恒王萍马剑峰王丽
Owner SHANDONG UNIV
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