Extracorporeal whole body hyperthermia using alpha-stat regulation of blood pH and pCO2

a whole body hyperthermia and alpha-stat technology, applied in the field of extracorporeal whole body hyperthermia using alpha-stat regulation of blood ph and pco2, can solve the problems of increased respiratory rate effectively, reduced pco.sub.2 (and total co.sub.2) of circulating blood, and plagued soldiers

Inactive Publication Date: 2003-07-22
FIRST CIRCLE MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Another object of the present invention is to provide a method of treating the patient's blood during extracorporeal hyperthermic treatment, whereby, the biochemical reactions fundamental to the metabolic welfare of the organisms in a patient's blood is stabilized.
Yet anot...

Problems solved by technology

These problems have plagued soldiers on the battlefield, inner city residents during heat waves, and clinicians trying to treat cancer and AIDS.
A negative consequence of hyperventilation is that an increased respiratory rate effectively and drastically reduces the pCO.sub.2 (and total CO.sub.2) of the circulating blood creating a respiratory alkalosis.
Additionally, cellular function may be impaired as enzyme ...

Method used

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  • Extracorporeal whole body hyperthermia using alpha-stat regulation of blood pH and pCO2
  • Extracorporeal whole body hyperthermia using alpha-stat regulation of blood pH and pCO2
  • Extracorporeal whole body hyperthermia using alpha-stat regulation of blood pH and pCO2

Examples

Experimental program
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Effect test

example 1

Given that the Arterial blood gas pH=7.5, pCO.sub.2 =25, and HCO.sub.3.sup.- concentration=16 1. Normal arterial bicarb=24 mEq / L 2. pCO.sub.2 is decreasing, therefore subtract -3 mEq / L; Hence, anticipated bicarb=21 mEq / L 3. (anticipated bicarb=21)-(measured bicarb=16)=5 mEq / L base deficit

example 2

Given that the Venous blood gas pH=7.1, pCO.sub.2 =50, and HCO.sub.3.sup.- concentration =12 1. Normal .[.arterial.]. .Iadd.venous .Iaddend. bicarb=26 mEq / L 2. pCO.sub.2 is increasing, therefore add 1 mEq / L; Hence, anticipated bicarb=27 mEq / L 3. (anticipated bicarb=27)-(measured bicarb=12)=15 mEq / L base defecit or -15 mEq / L base excess

A negative base excess, sometimes referred to as base deficit indicates metabolic acidosis and is treated with Sodium bicarbonate (NaHCO.sub.3). A positive base excess indicates metabolic alkalosis which is generally not seen during extracorporeal circulation but can occur due to over use of bicarb and can be treated by the use of a slightly acidotic crystalloid solution such as Normal Saline (0.09% NaCl) solution

Generally a base excess of 0.+-.3 mEq / L is clinically acceptable and no action is normally taken. When the base excess exceeds these values, the following action is taken. When there is a base deficit, the extracellular fluid (ECF) [volume.tim...

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Abstract

A device and method for extracorporeal whole body hyperthermia treatment of a patient's blood using alpha-stat regulation of blood pH and pCO2 is described. The respiratory rate of a patient is either increased or decreased in accordance with the changes in pH, pCO2, and base excess. The regulation of blood during the hyperthermic treatment of the patient's blood stabilizes the biochemical reactions fundamental to the metabolic welfare of the organisms within the patient's blood while the viruses within the patient's blood are eliminated.

Description

FIELD OF THE INVENTIONThis invention relates generally to an apparatus and method for eliminating viruses by means of extracorporeal whole body hyperthermia, and more particularly to an apparatus and method that regulates the blood pH, pCO.sub.2, and base excess, thereby maintaining a constant CO.sub.2 as the patients body temperature is increased.BACKGROUND OF THE INVENTIONThe use of heat to treat ailments dates back many centuries to ancient Egyptian times, where certain cancers were treated by partial burial of the patient in hot sand. The use of hyperthermia as a treatment has continued into the twentieth century. Hyperthermia presents a unique set of physiologic problems that require careful management in order to achieve success. These problems have plagued soldiers on the battlefield, inner city residents during heat waves, and clinicians trying to treat cancer and AIDS.In homoiothermal bodies, thermoregulation and maintenance of near normal temperature automatically takes pr...

Claims

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Application Information

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IPC IPC(8): A61M1/36A61M16/00
CPCA61M1/369A61M16/00A61M2230/202A61M2230/205
Inventor KELLY, THEODORE C.
Owner FIRST CIRCLE MEDICAL
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