306 results about "Intolerances" patented technology

Apparatus and methods are provided comprising an implantable non-hydraulic ring that encircles and provides a controllable degree of constriction to an organ or duct and an external control that powers and controls operation of the ring. The ring includes a rigid dorsal periphery that maintains a constant exterior diameter, and a compliant constriction system that reduces intolerance phenomena. A high precision, energy efficient mechanical actuator is employed that is telemetrically powered and controlled, and maintains the ring at a selected diameter when the device is unpowered, even for extended periods. The actuator provides a reversible degree of constriction of the organ or duct, which is readily ascertainable without the need for radiographic imaging. Methods of use and implantation also are provided.

Apparatus and methods are provided comprising an implantable non-hydraulic ring that encircles and provides a controllable degree of constriction to an organ or duct and an external control that powers and controls operation of the ring. The ring includes a rigid dorsal periphery that maintains a constant exterior diameter, and a compliant constriction system that reduces intolerance phenomena. A high precision, energy efficient mechanical actuator is employed that is telemetrically powered and controlled, and maintains the ring at a selected diameter when the device is unpowered, even for extended periods. The actuator provides a reversible degree of constriction of the organ or duct, which is readily ascertainable without the need for radiographic imaging. Methods of use and implantation also are provided.

The present invention relates to characterizing changes in mammalian gastrointestinal microbiota associated with antibiotic treatment and various disease conditions (such as obesity, metabolic syndrome, insulin-deficiency or insulin-resistance related disorders, glucose intolerance, diabetes, non-alcoholic fatty liver, abnormal lipid metabolism, short stature, osteoporosis, and other disorders of bone formation and mineralization, etc.) and related diagnostic and therapeutic methods. Therapeutic methods of the invention involve the use of probiotics, prebiotics, or narrow spectrum antibiotics/anti-bacterial agents that are capable of restoring healthy mammalian bacterial gastrointestinal microbiota.

The present invention discloses a treatment for syndrome-X, and resulting complications, that include hyperlipidemia, hypertension, central obesity, hyperinsulinemia and impaired glucose intolerance. Diabetic complications include excess proinsulin levels.

It is intended to provide a method of forming pancreatic β cells from mesenchymal cells characterized by comprising using mammal-origin mesenchymal cells as starting cells, culturing these cells in the presence of, for example, a pancreatic β cell-forming agent, and selecting and separating the thus obtained pancreatic βcells with the use of a gene expressed specifically in such cells as a selection marker; a remedy for glucose intolerance which comprises pancreatic β cells obtained by the above method as the active ingredient; a pancreatic β cell-forming agent such as a cytokine to be used in the above method; a method of screening a candidate compound promoting the formation of pancreatic β cells from mesenchymal cells; and a pancreatic β cell formation promoter obtained by this screening method.

The invention relates to the use of compounds to treat a number of conditions, such as a pre-diabetes condition, type 1 diabetes, type 2 diabetes, hyperglycemia, insulin resistance and glucose intolerance. Compounds that can be used in one or more of the treatment methods include 3β,7β,16α,17β-tetrahydroxyandrost-5-ene, 3α,7β,16α,17β-tetrahydroxyandrost-5-ene, 3β,7β,16α,17β-tetrahydroxyandrost-5-ene, 3β,16α,17β-trihydroxyandrost-5-ene-7-one, 3β,7β,17β-trihydroxy-17α-ethynylandrost-5-ene, 3β,17β-dihydroxy-17α-ethynylandrost-5-ene-7-one and 3β,7α,17β-trihydroxy-17α-ethynylandrost-5-ene.

A composition for the treatment, prevention or management of a condition in primates, especially humans comprising a phenolic antioxidant-chromium complex.

An infant formula specially designed for covering nutrition necessities of infants between 0 and 36 months of life is described, which reduces the intolerance problems related to the consumption of infant formulas currently found in the art.

New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I, IA, IB and IC, and their pharmaceutical acceptable salts are described for prevention or treatment of diabetes or a diabetes-related disorder in a subject in need thereof. Diabetes and diabetes-related disorder include Type I diabetes, Type II diabetes, maturity-onset diabetes of the young, latent autoimmune diabetes of adults (LADA), gestational diabetes, diabetic nephropathy, proteinuria, ketonuria, obesity, hyperglycemia, glucose intolerance, insulin resistance, hyperinsulinemia, hypercholesterolemia, hypertension, hyperlipoproteinemia, hyperlipidemia, hypertriglyceridemia, dyslipidemia, metabolic syndrome, syndrome X, diabetic neuropathy, diabetic retinopathy, hypoglycemia, cardiovascular disease, atherosclerosis, diabetic kidney disease, ketoacidosis, thrombotic disorders, sexual dysfunction, dermatopathy, edema, metabolic syndrome and renal disorders. The related pharmaceutical compositions and methods are also described. These compounds can be used in combination with comprising a therapeutic agent for lowering or controlling blood glucose level such as metformin or a thiazolidinedione.

The present invention provides pharmaceutical compositions comprising: (a) a modulator of hepatic parasympathetic tone, (b) at least one diabetes drug, and (c) a pharmaceutically acceptable carrier. The present invention includes methods for the treatment and/or prevention of insulin resistance, type 2 diabetes, impaired glucose intolerance, and other associated disorders with pharmaceutical compositions described herein. The invention also provides for a kit comprising a pharmaceutical composition and instructions for its use.

Methods, articles of manufacture and compositions are provided useful for the prevention or amelioration of a symptom of acetaldehyde accumulation or ethanol intolerance in a subject with reduced or absent reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity wherein about 1 mg/kg to about 4 mg/kg 4-methylpyrazole, or an equivalent mass of a 4-MP salt, are to be orally administered to the subject.

A nutritional composition for controlling blood sugar level comprising a protein, a lipid and a carbohydrate, wherein energy percentages supplied by the protein, lipid and carbohydrate are 10 to 25%, 20 to 35% and 40 to 60%, respectively; and oleic acid in the lipid energy percentage is 60 to 90% and palatinose and/or trehalulose in the carbohydrate energy percentage is 60 to 100%. The composition is useful as an oral or tube feeding nutrient for nutritional management or blood sugar level control of patients suffering from diabetes and glucose intolerance, or for obesity prevention, a therapeutic diet, a diet for diabetic patients at home, an obesity preventive diet or a food with health claims.

The invention relates to active ingredients capable of stimulating direct or indirect expression of type 2 human beta-defensins and/or type 3 human beta-defensins. The invention thus provides an active ingredient capable of stimulating direct or indirect expression of type 2 human beta-defensins and/or type 3 human beta-defensins, characterized in that said active ingredient does not cause any inflammatory, irritation or intolerance reactions. The invention also provides a screening method for the selection of such active ingredients. The invention is applicable to the preparation of cosmetic or pharmaceutical compositions containing such active ingredients.

The present invention provides a proprietary compositions and systems to modulate genetic and metabolomic contributing factors affecting disease diagnosis, stratification, and prognosis, as well as the metabolism, efficacy and/or toxicity associated with specific vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients for the purposes of customizing a subject's nutritional supplement formulation to optimize specific health outcomes. Specific to this invention the utilization of certain known polymorphic genes associated with Substance Use Disorder (SUD) are analyzed to target certain genetic anomalies that lead to a high risk and predisposition to SUD. The genotypic patterns are then utilized to provide certain nutritional customized solutions especially related to the attenuation of aberrant abuse of physician prescribed narcotic pain medication across all pain conditions. A priority GENOPROFILE is measured and directs the customization of a subsequent nutraceutical to act as a therapeutic modality. Specifically the treatment includes slow attenuation of the pain medication by incorporating orals (shakes, liquid beverages, pills, tablets, troche, ointments etc.), Intramuscular, Intravenous, intra-rectal and any form necessary to deliver a sufficient amount of an anti-craving and anti-stress nutraceutical. Moreover, the invention includes examples of novel analgesic ointments coupling Synaptamine and such analgesic and other anesthetic compounds including but not limited to Gabapentin, Ketamine, Baclofen, Ketoprofen, Amitriptyline, Lidocaine, Cyclobenzapine, Diclofenac, Menthol, Camphor and Capsaicin. The GENOPROFILE will be used to determine pain sensitivity Intolerance.

The invention provides a preparation method of purple sweet potato juice which is prepared with purple sweet potatoes by the following steps of cleaning, selection, cutting, fragmentation, juicing, filtration, sterilization, clarification, ultrafiltration, concentration, pasteurization and filling. The purple sweet potato juice prepared by the invention solves the problem of storage intolerance of purple sweet potatoes; and the concentrated purple sweet potato juice contains the natural components and efficacy of purple sweet potatoes, can be used to prepare purple sweet potato beverages or other mixed fruit juice beverages.

The invention relates to a low-lactose milk powder and a preparation method thereof. The lactose content of the low-lactose milk powder of the invention is 4.5-10%; the preparation method of the low-lactose milk powder includes that lactose enzyme is added into crude milk for hydrolysis after pasteurization on crude milk and before production burdening on the basis of the conventional production process. The invention adopts advanced biological enzymolysis technology, through researches on technological conditions of the steps of burdening, filtration, homogenizing, preheating and sterilization, evaporation concentration, spray drying, cooling, sieving, packaging and the like, a low lactose milk power is developed, the milk powder is full of nutriments, lactose hydrolysis rate can be above 70%, not only intolerance symptom of lactose intolerant people to lactose can be relived, but also the requirement of the lactose intolerant people on flavour and taste can be met.

This invention relates to natual medicine chemical and medical technique field. It discloses two kind celosin new compounds of celosin A and celosin B structure and its distillation and eperating method from amaranthcea plant celosin. Their chemical general formula is shown as formula (1). This invention also discloses the compound and its derivative medicine aspect application of curing and preventing fatty liver, liver injury, hepatic fibrosis, liver cirrhosis, coronary heart disease, cardiac infarction, myocardial ischemia, cerebral ischemia, cerebral infarction, cerebral apoplexy, diabetes mellitus, hyperinsulinism, insulin resistance disease, obesity, glucose intolerance capability, and/or hypertension adiposity, hyperlipemia, dementia, depression or anxiety, and insomnia diseases.

The invention discloses a blood-harmonizing and qi-tonifying medicinal liquor which is prepared by taking the following Chinese traditional medicines as raw materials in parts by weight: 11-13 parts of radix astragali, 11-13 parts of poria with hostwood, 5-7 parts of rhizoma atractylodis macrocephalae, 7-9 parts of rehmannia glutinosa, 7-9 parts of angelica sinensis, 7-9 parts of radix rehmanniae, 5-7 parts of radix codonopsitis, 5-7 parts of radix ophiopogonis, 5-7 parts of poria cocos, 5-7 parts of citrus chachiensis hortorum, 5-7 grams of fructus corni, 5-7 parts of lycium chinensis, 5-7 parts of ligusticum wallichii, 5-7 parts of radix sileris, 5-7 parts of tortoise plastron glue, 5-6 parts of Chinese magnoliavine fruits, 5-6 parts of rhizoma et radix notopterygii, 3-5 parts of cortex cinnamomi, 190-210 parts of red dates, 190-210 parts of rock candy, 180-220 parts of wheat koji and 1800-2200 parts of glutinous rice. The medicinal liquor disclosed by the invention can be used for tonifying qi and harmonizing blood, tonifying essence and complementing the marrow, and has better curative effects on deficiency of qi and blood, soreness and weakness of the waist and knees, mind and force fatigue, palpitation, amnesia, spontaneous perspiration, night sweat, intolerance of cold, sensibilization and the like.

The invention discloses a bream compound feed and a preparation method thereof. The compound feed comprises the following raw materials: flour, wheat, expanded dehulled soybean meal, double-low rapeseed meal, cottonseed meal, fish meal, spray-dried animal blood cells, peanut meal, corn liquor dregs, rice bran, soybean oil, soybean lecithin oil, choline chloride, ammonia absorption zeolite powder, calcium dihydrogen phosphate, common salt, coated vitamin C, Chinese herbal medicine extract, liver-protective and choleretic agent, microbial preparation for aquatic products, bream compound premix and the like. The bream compound feed disclosed by the invention can meet all the nutritional requirements of bream, effectively avoid the problems of fish body redness, hairy property, abhesion, intolerance to transportation and the like, has high feed transformation ratio, enable the feed coefficient to be 1.5-1.9, realize good fish body vitality of the bream, improve a water body environment and realize obvious economic benefits.

The invention discloses a Chinese medicinal preparation for relieving body fluid deficiency for people with yin-deficiency physique, a preparation method thereof and application thereof. The Chinese medicinal preparation comprises the following raw material medicaments in part by mass: 40 to 70 parts of fragrant solomonseal rhizome, 80 to 110 parts of prunus japonica thumb, 60 to 150 parts of lily, 60 to 190 parts of liquoric root, 20 to 60 parts of manyflower solomonseal rhizome, 90 to 160 parts of cinnamomvine, 80 to 170 parts of medlar, 20 to 60 parts of cassia seed, 30 to 70 parts of mulberry, 40 to 60 parts of mulberry leaf, 30 to 60 parts of chrysanthemum, 50 to 80 parts of peach seed, 40 to 70 parts of black sesame, 30 to 70 parts of citrus chirocarpus and 40 to 80 parts of platycodon root. The Chinese medicinal preparation for relieving the body fluid deficiency of the people with the yin-deficiency physique is subjected to compatibility by using plants which are homologous in medicines and food, does not have side effect, and can relieve or eliminate bad symptoms such as fever in bodies and faces, intolerance in summer-heat, skin drying, fever in palms and arches of feet, flushing or reddish check, aningeresting in eyes, dryness in mouths and throats, insomnia, constipation and the like of the people with the yin-deficiency physique effectively.

The invention discloses a Chinese materia medica preparation for treating borborygmus diarrhoea and a preparation method thereof. The Chinese materia medica preparation comprises the following components: Chinese pulsatilla root, common yam rhizome, stir-fried gordon euryale seed, parslane herb, costus root, nutmeg, largehead atractylodes rhizome, poria, voilet, longstamen onion bulb, areca peel, golden thread and tangerine peel. When the patient also obviously suffers from lumbago, cold intolerance, hypogastric pain and diarrhoea when getting up in the morning, the Chinese materia medica preparation is added with cassia bark, south dodder seed, Chinese magnoliavine fruit and rehmannia glutinosa. When the patient suffers from obvious bellyache, abdominal distension and pain reduction after diarrhoea, the Chinese materia medica preparation is added with officinal magnolia bark, bitter orange, white paeony root, kudzu-vine root and divaricate saposhnikovia root. When the patient suffers from poor appetite and apepsia, the Chinese materia medica preparation is added with charred triplet and chicken's gizzard-membrane. The Chinese materia medica preparation of the invention has effects of calming the liver and relieving pain, regulating Qi and strengthening the spleen, tonifying spleen, lungs and kidney, tonifying middle-Jiao and Qi and lifting yang and relieving diarrhea, mainly treats symptoms of acute and chronic enteritis, colonitis, borborygmus diarrhoea caused by liver-yang hyperactivity and weak spleen and stomach, poor appetite and loose stools, limb tiredness and hypodynamia, pain releasing after diarrhoea, repeated attacks and the like, has simple formula and low manufacturing cost and can be popularized and used.