Lens and associatable flow cell

a flow cell and lens technology, applied in the field of diagnostic equipment components, can solve the problems of deformation or warping of the waveguide portion of the integrally formed or molded biosensor, interfere with the desired analysis, and not reliably seal, so as to increase the performance of the biosensor, improve the coupling efficiency and beam quality, and improve the effect of monitoring coupling efficiency

Inactive Publication Date: 2007-08-14
UNIV OF UTAH RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The invention also includes orienting the biosensor in a particular position relative to an optical reading device and laser which increases the performance of the biosensor to the point where, surprisingly, whole blood can be quickly analyzed.

Problems solved by technology

Unfortunately, the waveguide portion of integrally formed or molded biosensors may exhibit deformation upon fabrication, or warping during storage or temperature changes.
Also, gaskets may not reliably seal or are not always sufficiently inert to reactants, and thus may interfere with the desired analysis.

Method used

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  • Lens and associatable flow cell
  • Lens and associatable flow cell
  • Lens and associatable flow cell

Examples

Experimental program
Comparison scheme
Effect test

example i

[0092]A waveguide with integrated lenses, such as that depicted in FIGS. 6 & 7, was injection molded in a clean environment from a transparent, general purpose polystyrene. The waveguide had a length of 38 mm, and a width of 25 mm. The thickness 176 of the planar surface 170 was a consistent 0.5 mm. The ridge or “shelf” had a height of 1.3 mm. The front lens and rear lens had bottom edges co-planar with their respective centers of curvature. The front lens horizontal angle 262 was about 15°. The rear lens horizontal angle 264 was about 19°. The radii of curvature of the front and rear lenses were about 3.2 mm and 1.6 mm respectively. The mean angle θ of the front lens was 21°. The mean angle of the rear lens was about 24°.

example ii

[0093]A flow cell top, such as that depicted in FIGS. 1-3, and 8, was made of hard black anodized 6061-T6 aluminum. It contained three reservoirs each of which had a 0.25 mm (0.010 in.) thick wall surrounding it, a flat floor in middle, two half-capsule shaped recesses at either end 1.6 mm ( 1 / 16 in.) in width, and ports 1.6 mm ( 1 / 16 in.) in diameter running into the center of each recess. The ports opened into a #10-32 (standard thread, not NPT) connector which ran out to the opposite face of the flow cell and was 5.1 mm (0.200 in.) deep. A 90° countersink 266 (FIG. 2) was given at the surface of the port connector (a plastic barbed tubing connector screwed into the port connector and sealed on the countersink). On both sides of the array of reservoirs were two raised platforms which were referred to as lands 268, 270. Each land had three holes running through the thickness of the part. The four #31 clamping holes 272, 274, 276, 278 were formed (i.e. drilled through). The two aper...

example iii

[0094]A gasket 162, such as that depicted in FIGS. 4, 5, and 11, was made as a composite structure laminated from 1.6 mm ( 1 / 16 in.) silicone rubber sheeting and 0.076 mm (0.003 in.) self-adhesive FEP film (total thickness: 1.676 mm (0.066 in.) nominal). Its outer dimensions were about 25 mm (1 in.) by 25.40 mm (1.000 in.) and it had three internal openings which corresponded to the flow cell reservoirs. The gasket was produced using a waterjet cutter and was seated on the flow cell such that the FEP layer faced away from the flow cell surface.

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Abstract

Improvements in a biosensor of the type having reservoirs or wells for analyzing a biological liquid are disclosed. A biosensor (190) includes a waveguide (164) placed between a plurality of members such as plates (100, 186), at least one of the members (100) being formed to define the walls (132, 134, 136) of the reservoirs where the liquid is biologically analyzed. The walls of the reservoirs are made of an inert, opaque material such as a metal. Although the biosensor may include a gasket (162), the gasket is associated with the members and waveguide in such a way (e.g. by recessing the gasket into a channel formed into a metal plate) so that the gasket does not form any significant portion of the reservoir wall. Waveguides of varying composition (e.g. plastic, quartz or glass) may be associated with the members to form the biosensor. The metal plate of the biosensor has input and output ports for infusing, draining, or oscillating the liquid to be analyzed in the reaction reservoir. Also disclosed is a sled-shaped waveguide associated with a rear lens to couple light out of the waveguide to serve as a quality control measure thus insuring that the biosensor is properly placed and that the light is working.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is an application under 35 U.S.C. § 371 of PCT / US97 / 04398 filed on Mar. 19, 1997, claiming priority from U.S. Provisional patent application No. 60 / 022,434 filed on Aug. 8, 1996 and U.S. Provisional patent application No. 60 / 013,695 filed on Mar. 19, 1996.TECHNICAL FIELD[0002]This invention relates generally to components of a diagnostic apparatus, and more particularly to an improved biosensor having a lens (“waveguide”) and associated flow cell.BACKGROUND ART[0003]International Application No. PCT / US94 / 05567 (International Publication No. 94 / 27137, published Nov. 24, 1994) to the University of Utah Research Foundation discloses an apparatus for multi-analyte homogeneous, fluoroimmunoassays. In one embodiment, the application discloses an apparatus which uses a biosensor having a planar waveguide sandwiched, with an associated gasket, between two plates (FIGS. 3A-3C of Internat'l Publ. No. 94 / 27137). The inner edges of t...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): G02B6/26G01N21/00G01N33/552G01N33/72G02B6/10G01N21/64G01N21/03G01N21/05G01N33/543G02B6/00G02B6/32
CPCG01N21/0303G01N2021/058
Inventor HERRON, JAMES N.CHRISTENSEN, DOUGLAS A.POLLACK, VICTOR A.MCEACHERN, RICHARD D.SIMON, ERIC M.
Owner UNIV OF UTAH RES FOUND
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