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Methods of treating chronic inflammatory diseases using carbonyl trapping agents

InactiveUS6444221B1Improved therapeutic propertyImprove propertiesBiocidePeptide/protein ingredientsEtiologyBenzoic acid
These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic "inflammatory cascade" process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods. The carbonyl sequestering agents are used in combination with at least one co-agent so as to produce an additional beneficial physiological effect of an anti-inflammatory nature. Such compositions are administered systemically entirely via the oral route. Co-agents of the present invention include anti-oxidants and free radical trapping compounds (e.g., alpha-tocopherol), compounds having indirect anti-oxidant activity (e.g., selenium), vitamins (e.g., pyridoxine HCl), compounds which facilitate kidney drug elimination (e.g., glycine), metabolites at risk of depletion (e.g., pantothenic acid), sulfhydryl containing chemicals (e.g., methionine), compounds which facilitate glutathione activity (e.g., N-acetylcysteine), and non-absorbable polyamine co-agents (e.g., chitosan).
Owner:SECANT PHARMA

Methods and systems for inferring traits to breed and manage non-beef livestock

InactiveUS20050153317A1Maximize individual potential performanceMaximize product valueMicrobiological testing/measurementBiotechnologyZoology
Methods and systems are provided for managing non-beef livestock subjects in order to maximize their individual potential performance and the value of a product from the non-beef livestock subjects, and to maximize profits obtained in marketing the non-beef livestock subjects. The methods and systems draw an inference of a trait of a non-beef livestock subject by determining the nucleotide occurrence of at least one non-beef livestock SNP that is determined to be associated with the trait. The inference is used in methods of the present invention to establish the economic value of a non-beef livestock subject, to improve profits related to selling beef from a non-beef livestock subject; to manage non-beef livestock subjects, to sort non-beef livestock subjects; to improve the genetics of a non-beef livestock population by selecting and breeding of non-beef livestock subjects, to clone a non-beef livestock subject with a specific trait, to track meat or another commercial product of a non-beef livestock subject; and to diagnose a health condition of a non-beef livestock subject. Certain embodiments of the present invention provide methods, systems, and kits are directed to inferences of a trait related to milk or a dairy product in a livestock subject.
Owner:METAMORPHIX

Hosted system for enabling enterprises to build and operate online communities

InactiveUS20090327232A1Safely and securely developSafely and securely and executeDigital data processing detailsWebsite content managementData setUser-generated content
A system that enables enterprises to design, create integrate and operate online communities. The system operates as an on-demand hosted platform (software-as-a-service) that provides a secure and reliable architecture on which enterprises can safely and securely develop, execute and manage their online communities. The platform combines a wide range of web-based participation technologies (e.g., blogs, wikis, discussion groups, social networking, podcasts, RSS, tagging, photos, videos, mapping, and the like). Any content can have attributes that make it appear as any type of content. With this uniform content architecture, all user-generated content is treated as a post (or, more generally, a submission), and there is no need for a participant to author multiple entries for separate uses. Preferably, all content created or otherwise associated with a particular author is intrinsically tied or “linked” to the author via the author's profile. Thus, at each point of participation, the content is associated with the individual, which allows the system to build and maintain a rich “living” profile for each community member. Using this approach, the system can build and enable querying of so-called “social aggregations,” which are data sets that describe a relationship among one or more author attributes and one or more content attributes.
Owner:GJR HLDG +1

Fully integrated on-line interactive purchasing club incorporating extremely rapid fulfillment

A method for implementing a computer-based product purchase and fulfillment club is disclosed, comprising the steps of designating one or more geographic club member areas; associating with each such club member area one or more consumer members who reside within the club member area and who must agree to pay a membership fee to the club; associating with each such club member area one or more buyer members who must be prepared to work within the club member area and who must agree to pay a membership fee to the club; associating with each such club member area one or more retailer members who must offer products for sale within the club member area and who must agree to pay a membership fee to the club; providing means through an electronic communications network for the consumer members, buyer members and retailer members to access a club web site specific to the club member area and to interact with the club web site; providing means through an electronic communications network for the consumer members, buyer members and retailer members to each access an individual member web page located on the club web site and personalized using parameters specific to each such consumer member, buyer member and retailer member; providing means through software programming for the retailer members to offer one or more products for sale on the club web site to the consumer members; providing means through software programming for the consumer members to purchase products offered for sale on the club web site; providing means through software programming for the buyer members to be notified of purchases made by the consumer members and to offer to the retailer members to fulfill the purchases; and fulfilling the purchases by having the buyer members buy the products from the retailer members, deliver the products to the consumer members to a location within the club member area within approximately thirty (30) minutes of the purchase, and collect a payment from the consumer members.
Owner:CHERRY RICHARD SUTTON
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