The invention provides a comprehensive protecting and treating method of a water-containing easily-weathered rock bedding slope. The method comprises the following steps that 1, positions of bedding joints, water isolating layers, rock crushing zones and water guide channels are explored and determined on site; 2, steps from the first to the Nth are formed in an exploited manner, a water drainageditch is constructed in the bottom of a slope face, water drainage holes are constructed in the slope face, thus water accumulated in the steps is drained away, and a water intercepting ditch is constructed in the slope top; 3, slurry injecting holes are constructed in the slope face to enable the rock crushing zones to be combined into a whole; 4, mixed clay is used for being laid on the slope top, and then grinding is carried out; 5, short anchoring rods are constructed on the slope face, and the method of full-hole slurry injecting is used for anchoring; and 6, concrete is adopted for carrying out net hanging and slope spraying. According to the method, the stability of the slope is improved fundamentally, contact between easily-weathered rocks and atmosphere, sunlight and water is isolated, weathering damage to slope rock mass is prevented, the strength of the rock mass is given into play, the key effect of the water in slope slippage is eliminated, and long-term stability of the slope is improved.