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Method for preparing porous bone scaffold by laser and increasing performance by adding zinc oxide

A performance, laser sintering technology, applied in the field of bone tissue engineering, can solve the problems of fast biodegradation, inability to match the rate, limited use, etc., to achieve the effect of promoting proliferation, refining grain size, and enhancing mechanical properties

Inactive Publication Date: 2014-06-11
CENT SOUTH UNIV
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Problems solved by technology

However, β-TCP has shortcomings such as high brittleness and low strength, which limit its use in the weight-bearing parts of the human body.
And the biodegradation rate is fast and difficult to control, which cannot match the rate of new tissue generation

Method used

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  • Method for preparing porous bone scaffold by laser and increasing performance by adding zinc oxide
  • Method for preparing porous bone scaffold by laser and increasing performance by adding zinc oxide
  • Method for preparing porous bone scaffold by laser and increasing performance by adding zinc oxide

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Embodiment Construction

[0028] The specific implementation manner of the present invention will be further described below in conjunction with an embodiment, but the content of the present invention is not limited thereto.

[0029] 1) A small amount of ZnO powder was added to β-TCP powder, and mixed uniformly by mechanical mixing method to prepare β-TCP / ZnO mixed powder with a ZnO mass fraction of 2.5%.

[0030] 2) Place the obtained mixed powder in the self-developed SLS system. Under the control of the computer, the laser selectively sinters the powder according to the interface profile information. After one layer is completed, the next layer is sintered, and finally a product with Three-dimensional interconnected porous β-TCP scaffold. The porous β-TCP scaffold by selective laser sintering is shown in the attached figure 1 , which shows that the selective laser sintering technique can prepare porous β-TCP scaffolds with three-dimensional interconnection.

[0031] 3) The mechanical properties of...

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Abstract

The invention relates to a method for preparing a porous bone scaffold by laser and increasing mechanical and biological performances of the porous bone scaffold by adding zinc oxide with little amount, which belongs to the bone tissue engineering field. Aiming at uncontrollable performances of aperture distribution, shape, space direction and connectivity in the preparation method of a traditional bone scaffold, and aiming at the disadvantages of poor mechanical property and fast resolving rate existed in tricalcium phosphate (beta-TCP), the invention provides the method for preparing the porous bone scaffold by using a selective laser sintering (SLS) technology, and provides the method for increasing performance by adding zinc oxide (ZnO). The method for preparing the porous bone scaffold has the advantages that the porous scaffold which enables three-dimensional interconnection is prepared by SLS, zinc oxide with little amount is added for introducing into a liquid phase, the particles densification can be promoted, crystal grain is refined, and the mechanical performance is improved, simultaneously, cell compatibility is increased, the degradation rate is reduced, and the biological performance is increased, so that the interconnected porous beta-TCP bone scaffold with enhanced mechanical performance and good biological performance can be finally prepared. The method has the advantages of simple preparation technology, convenient operation, low cost, easy control of technical parameter and the like.

Description

technical field [0001] The invention relates to a three-dimensional interconnected porous bone scaffold prepared by selective laser sintering (SLS) technology, and a small amount of zinc oxide (ZnO) is added to increase tricalcium phosphate (β-Ca 3 (PO 4 ) 2 , a method for the mechanical and biological properties of a β-TCP) scaffold, belonging to the field of bone tissue engineering. Background technique [0002] Tissue engineering is a discipline in which cells are planted on a three-dimensional scaffold with a certain spatial structure. Cells grow, proliferate, differentiate and build biological substitutes on the scaffold, and then transplanted to the tissue defect site to restore tissue function. Bone tissue engineering scaffolds not only provide support for the construction of tissue cells, but also provide a suitable external environment for cell growth, so as to facilitate the adhesion, proliferation and differentiation of bone cells. This requires the scaffold to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/12A61L27/02
Inventor 帅词俊彭淑平冯佩
Owner CENT SOUTH UNIV
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