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Method of preparing hydroxyapatite

A technology of hydroxyapatite and a new method, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as expensive, difficult to control size and size uniformity, and achieve good biological activity

Inactive Publication Date: 2007-07-18
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods are still unsatisfactory: some require expensive raw materials, such as the sol-gel method, and some are difficult to control the size and uniformity of the size, such as the co-precipitation method; some require more sophisticated equipment, e.g. airgel decomposition

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  • Method of preparing hydroxyapatite
  • Method of preparing hydroxyapatite
  • Method of preparing hydroxyapatite

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Embodiment Construction

[0034] Different from other wet methods for preparing hydroxyapatite, the preparation process of this method is to prepare calcium-containing glass with various initial raw materials. The glass has a large solubility in the solution. In the phosphorus-containing solution, no matter how much the phosphorus content is, (such as medical phosphate buffer solution, human physiological simulation solution, or even in the reaction solution of physiological saline without phosphorus, The phosphorus in the glass is dissolved, and the reaction solution changes from a phosphorus-free solution to a phosphorus-containing solution, that is, a secondary phosphorus-containing solution). When the pH of the solution is greater than 7, at 37 ° C, it can Formation of hydroxyapatite. That is to say, under the physiological environment of the human body, the glass can dissolve and form hydroxyapatite, which is the first characteristic of this method. The second is that since the dissolution rate o...

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Abstract

The invention will have a certain shape of vitreous immersed in the solution, adjusting the pH more than 7, stirring constantly, and depositing nanometer-scale hydroxyapatite on the glass surface. When dissolved all the glass, the glass in situ formed same size hydroxyapatite physical as the glass exterior. Soluble glass network is constituted oxide B2O3 or P2O5 or both, or part of both SiO2. Except CaO, glass networks gap oxides also contain one or more of the other monovalence, bivalence, tervalence, quadrivalence metal oxides, to regulate the speed of the solubility. The process is simple, easy to operate and low cost. Under the temperature of close proximity to human body, glass particles which contain calcium can combine with phosphorus in the body fluids to form inorganic mineral components, carbonic acid hydroxyapatite ceramic, which is closer to human bone tissue. Thus, this method has broad aspects of the application in the preparation of materials for hard tissue repair and bone in vitro tissue for culturing cells in bone scaffolds.

Description

technical field [0001] The invention belongs to the field of biomaterials, and relates to a method for preparing main scaffold materials that can be used for bone cell growth in tissue engineering. Background technique [0002] Hydroxyapatite is an important inorganic mineral component of human and animal bones and teeth. It has good biocompatibility and bioactivity, and can form a strong chemical bond with human or animal bone tissue. Under the action of body fluids, partial degradation and absorption will occur, and some calcium and phosphorus ions will be leached out, which will be absorbed and utilized by human or animal tissues. New tissue grows, thereby producing bone tissue conduction. Therefore, synthetic hydroxyapatite plays an important role in the field of hard tissue repair and replacement. [0003] There are sol-gel method, acid-base reaction method, aerosol decomposition method and so on to synthesize hydroxyapatite. For example, Chinese patents 97103827.9, 9...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
Inventor 黄文旵王德平周萘
Owner TONGJI UNIV
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