Digital coralline hydroxyapatite artificial bone scaffold and preparation method thereof

A technology of coral hydroxyapatite and artificial bone, which is applied in the field of medical devices, can solve the problem that it is difficult to manufacture the outline of bones, and achieves the effect of a simple preparation method.

Inactive Publication Date: 2010-10-13
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional stent manufacturing methods include phase separation / emulsification method, fiber bonding method, solution casting / particle leaching method, melt forming method, gas foaming method, etc., but there are fatal shortcomings, mainly manifested in the manual operation of the manufacturing process and the use of toxic materials. organic solvents, it is difficult to manufacture a shape that matches the bone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0028] The digitized coral hydroxyapatite artificial bone scaffold described in this embodiment is composed of coral hydroxyapatite artificial bone particles and L-polylactic acid mixed into a base material, and the mass ratio of coral hydroxyapatite artificial bone particles and L-polylactic acid is 3 : 1; carry out thin-layer CT scan through the bone segment, shape the artificial bone scaffold by an automatic molding machine and laser sinter, and make the above-mentioned mixture into a base material and sinter to form a digital coral hydroxyapatite artificial bone scaffold.

[0029] The coral hydroxyapatite is referred to as CHA, and the L-polylactic acid is referred to as L-PLA.

[0030] The preparation method of the present embodiment is as follows:

[0031] 1) Preparation of artificial bone blank

[0032] After cutting, Porites corals are ground into cubes with a size of about 1.5 cm, rinsed with 5% sodium hypochlorite solution for 3 days, soaked and rinsed with deionize...

specific Embodiment

[0050] The main features of other specific embodiments of the present invention are: the diameter of coral hydroxyapatite particles can be 300 μm, 400 μm, 500 μm, etc.; in each step of its preparation method:

[0051] The 1st) step prepares artificial bone blank, its size is the cube of 1.0 or 2.0cm, first rinses with 2%, 4%, 6% or 8% sodium hypochlorite solution for 3 days, 6 days or 8 days, repeats with deionized water Ultrasonic soaking and washing, putting it into a vacuum drying oven at a temperature of 100°C or 110°C for 20 hours, 23 hours, 28 hours or 30 hours, and drying to make artificial bone blanks;

[0052] Step 2) Prepare coral hydroxyapatite bone strips at a temperature of 220°C, 228°C or 230°C, and perform hydrothermal exchange treatment for 10 hours, 11 hours or 12 hours;

[0053] The 4th step is sintered and formed, and then cut out with a thickness of 0.10mm, 0.15mm, 0.20mm, 0.25mm or 0.3mm.

[0054] All the other are with specific embodiment 1.

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Abstract

The invention relates to a digital coralline hydroxyapatite artificial bone scaffold and a preparation method thereof. The preparation method is characterized by comprising the following steps: 1) mixing coralline hydroxyapatite artificial bone particles and poly-L-lactic acid into a base material based on the mass ratio of 3:1; and 2) carrying out thin-layer CT scanning on bone sections, forming the shape of the artificial bone scaffold by utilizing an automatic molding machine and then carrying out laser sintering on the mixed base material to obtain the digital coralline hydroxyapatite artificial bone scaffold. The invention overcomes the complicated technology for preparing micropores in a rapid forming process and the defects that the coralline hydroxyapatite artificial bone is difficult to be prepared into the bone scaffold in a specific shape according to the clinical need; and the prepared digital coralline hydroxyapatite artificial bone scaffold can fully remain the natural micropore structure and good biocompatibility of coralline hydroxyapatite (CHA), and can be prepared into various specific shapes according to the clinical need.

Description

technical field [0001] The invention relates to a coral hydroxyapatite artificial bone support and a preparation method thereof, which can be made into a digital coral hydroxyapatite artificial bone support widely used in repair and reconstruction operations in plastic surgery, trauma orthopedics and spinal surgery. It belongs to the technical field of medical equipment. Background technique [0002] Due to trauma, infection, bone tumors, and abnormal development of large bone defects, it is necessary to repair the defect in clinical practice, but it is a major problem that plagues clinical medicine. In the prior art, clinically used repair materials include autologous bone, allogeneic bone, tissue engineered bone, and the like. The advantage of using autologous bone is that there is no immune reaction, but there are disadvantages such as chronic pain and other complications at the bone harvesting site, and the amount of bone harvesting is limited, and its size and shape ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/18A61L27/12
Inventor 尹庆水林山张余
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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