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Bone scaffold material, with shape memory function, for jaw repair and preparation method thereof

A bone scaffold and jawbone technology, applied in the field of bone scaffold material with shape memory function and its preparation, can solve the problems of low radiation cross-linking efficiency, PCL tensile strength and elongation at break and other mechanical properties decline

Active Publication Date: 2015-02-18
DALIAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some current research reports point out that the radiation cross-linking efficiency of PCL is relatively low, while the cross-linking, cracking is also going on, and occupies a dominant position.
When the radiation dose is high, it will also cause a significant decline in the mechanical properties of PCL such as tensile strength and elongation at break.

Method used

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  • Bone scaffold material, with shape memory function, for jaw repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Bone Scaffold Preparation

[0024] 1) Stir and dissolve PCL, PBS and PLGA in dioxane, stir at 40°C at high speed to dissolve fully, and obtain a clear solution; the total concentration of PCL, PBS and PLGA is 0.2g / ml;

[0025] 2) Make TCP powder, NaCl particles with a particle size (diameter) of 450-500 μm and NaHCO with a particle size (diameter) of 75-100 μm 3 Add the particles to the solution in step 1, ultrasonically disperse the inorganic matter evenly, and freeze overnight at -20°C to obtain a solid; porogens are NaCl and NaHCO 3 , the weight ratio is 1:1, the total weight of PCL, PBS and PLGA is 1 / 4 of the porogen;

[0026] 3) Place the solid in an absolute ethanol solution at -20°C for 12 hours and in a hydrochloric acid solution with a pH of 5 for 24 hours, and finally immerse the solid in double distilled water, change the water every 12 hours, take it out after 6 days, and freeze Serve dry. In the bone scaffold material, PCL is 100 parts by weight, PBS is ...

Embodiment 2

[0029] Bone Scaffold Preparation

[0030] 1) Stir and dissolve PCL, PBS and PLGA in dioxane, stir at 40°C at high speed to dissolve fully, and obtain a clear solution; the total concentration of PCL, PBS and PLGA is 0.2g / ml;

[0031] 2) Make TCP powder, NaCl particles with a particle size (diameter) of 450-500 μm and NaHCO with a particle size (diameter) of 75-100 μm 3 Add the particles to the solution in step 1, ultrasonically disperse the inorganic matter evenly, and freeze overnight at -20°C to obtain a solid; porogens are NaCl and NaHCO 3 , the weight ratio is 1:1, the total weight of PCL, PBS and PLGA is 1 / 4 of the porogen;

[0032]3) Place the solid in an absolute ethanol solution at -20°C for 12 hours and in a hydrochloric acid solution with a pH of 5 for 24 hours, and finally immerse the solid in double distilled water, change the water every 12 hours, take it out after 6 days, and freeze Serve dry. In the bone scaffold material, PCL is 100 parts by weight, PBS is 3...

Embodiment 3

[0035] Effect of different weight ratios of PCL / PBS / PLGA / TCP on bone scaffold materials

[0036] Using PCL / PBS / PLGA / TCP with different weight ratios, bone scaffold materials were prepared respectively according to the method of Example 1, and the specific ratios were as follows:

[0037] parts by weight

PCL

PBS

PLGA

TCP

Comparative example 1

100

50

40

60

Comparative example 2

100

10

10

30

Comparative example 3

100

50

10

60

Comparative example 4

190

0

0

0

Comparative example 5

38

152

0

0

[0038] The tensile properties (tensile strength and bending strength) and shape recovery rate of bone scaffold materials were measured respectively:

[0039] Tensile properties refer to the national standard GB / T528-2009;

[0040] The method of measuring the shape recovery rate is to take a 10mm interval on the spline, mark it as L0, fix it for 12...

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Abstract

The invention belongs to the field of biology, and particularly relates to bone scaffold material, with a shape memory function, for jaw repair and a preparation method thereof. The bone scaffold material comprises the following raw materials in part by weight: 5 to 100 parts of polycaprolactone (PLC), 5 to 100 parts of poly butylenes succinate (PBS), 5 to 100 parts of poly (lactic-co-glycolic acid) (PLGA), and 5 to 100 parts of tertiary calcium phosphate (TCP). The bone scaffold material comprises the following raw materials in part by weight: 80 to 100 parts of polycaprolactone (PLC), 10 to 50 parts of poly butylenes succinate (PBS), 10 to 50 parts of poly (lactic-co-glycolic acid) (PLGA), and 30 to 60 parts of tertiary calcium phosphate (TCP). The method also provides a method for preparing the bone scaffold.

Description

technical field [0001] The invention belongs to the field of biology, and in particular relates to a bone support material with a shape memory function for jaw bone repair and a preparation method thereof. Background technique [0002] The repair of jaw defects has always been a difficult problem in oral and maxillofacial surgery and plastic surgery. Many patients suffer from jaw defects due to trauma, tumor resection, congenital diseases, etc. It is a common and frequently-occurring disease in oral and maxillofacial surgery, which seriously affects the physical and mental health of patients. Conventional treatment methods include: biomaterials, polymer compounds, allogeneic bone, autologous bone and other methods of repair. Allogeneic bone, biomaterials, and polymer compounds are prone to rejection when implanted in the body, and their osteogenic ability is uncertain. Autologous bone is a more commonly used method in clinical practice, such as ilium, rib, radius, and meta...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/16A61L27/12A61L27/56
Inventor 张静莹
Owner DALIAN UNIVERSITY
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