46 results about "Placental disc" patented technology

It is an object of the present invention to effectively promote growth of granulation tissue at a dermal defect or a subcutaneous tissue defect caused by a severe burn. To achieve this object, burn treatment cells for use in treatment of burns are composed of placenta-derived cells of an animal and promote healing.

A method for treating cartilage defects including providing a placental membrane preparation that comprises ground or minced placental membranes and optionally, a ground or minced cartilage and / or biocompatible glue, and introducing the preparation to a cartilage defect within a skeletal joint. The cartilage defect may comprise a hyaline cartilage defect, such as a chondral defect, or meniscal defect. The treatment may be provided in combination with other treatments such as marrow stimulation treatments and surgical repair treatments using sutures or other fixation techniques. The preparation promotes the regeneration of cartilage within the skeletal joint.

The invention belongs to the field of medical image processing, and provides an improved deep learning model based on U-Net for a placenta automatic segmentation task in a magnetic resonance imaging (MRI) image. Technical improvement key points are as follows: a convolutional block attention mechanism module (CBAM) is embedded in a down-sampling path, and the key channel and spatial feature extraction capability is enhanced; meanwhile, an edge perception enhancement module (BPM) is embedded, so that the edge distinction degree of the placenta and the uterus tissue is enhanced; in addition, an attention gating module (AG) is additionally arranged on an up-sampling path, the semantic distinguishing capability of a placenta target area and a background is improved, and background noise interference is reduced. Experimental verification shows that the segmentation precision of the model in a placenta MRI automatic segmentation task is obviously superior to that of an existing method.

The invention relates to the field of computer vision and medical images, in particular to a placental lesion tissue detection method and system based on artificial intelligence, and the method comprises the following steps: collecting and fusing multi-modal data, and obtaining the multi-modal data of placental lesion tissues by adopting an imaging technology; after the multi-modal data are aligned, lesion tissue labeling is carried out on the visible light image, and a reference label is obtained; and based on a cross-modal space mapping relationship, migrating the reference label to other modals to support multi-modal cooperative training. A software module of the system receives encrypted original data from a hardware module, a containerization technology is adopted to package a model and an operation environment thereof into independent units for deployment and operation, the detection method is realized, and the system is integrated with an external medical information system. According to the method, the detection rate of lesions is remarkably increased, the false detection rate is reduced, the detection performance is remarkably improved, and the detection environment deployment cost of a hospital is greatly reduced.

Disclosed herein are methods of reducing pathological inflammation and effects thereof through administration of tissues associated with regenerative and / or tolerogenic activity. In some embodiments, such tissues can include placental, ocular, testicular, and osseous tissues. Augmentation of therapeutic effects of said tissues may be achieved through contact with Injury Mimetics.

Provided herein is an ionizable lipid and a lipid nanoparticle composition including the ionizable lipid. The ionizable lipid and lipid nanoparticle composition are hypoxia responsive. Provided herein are also methods of delivering an agent to hypoxic tissue and treating disorders associated with hypoxia using the ionizable lipid and lipid nanoparticle composition. Such methods include treatment of placental related disorders.

The invention belongs to the technical field of medical diagnosis, and provides a biomarker of complete grape tire. The biomarker comprises RASA1, and the biomarker shows obvious differential expression in normal and complete grape tire trophoblast stem cells and normal and complete grape tire tissues; the method can be used for distinguishing complete grape tire, extremely early complete grape tire, non-grape tire villus edema and normal placenta tissue, and shows good robustness. Compared with the serum beta-hCG level, the expression level of the RASA1 shows higher diagnostic efficacy on complete grape tire detection. The biomarker disclosed by the invention provides a basis for developing targeted diagnosis and treatment in the future.

The invention relates to the technical field of auxiliary turning-over frames, in particular to an auxiliary turning-over device for gynaecology and obstetrics examination. An auxiliary pad is arranged at the upper end of a sickbed, two driving assemblies are arranged at the lower end of the auxiliary pad, a shoulder supporting assembly is rotationally installed at the upper end of one driving assembly, and a first rotating groove is formed in the auxiliary pad; a sectional type small-angle gradual turning mode is adopted, air bag buffering is matched, the lumbar vertebra twisting moment and abdomen compression during turning can be reduced, the risks of lumbar vertebra injury, placenta early peeling and the like are reduced, the comfort is high, and the effect is good. The shoulder supporting air bag fits the body shape of a pregnant woman in a net bag type wrapping design, the leg supporting assembly and the abdomen supporting assembly are automatically lifted through transmission of silica gel extruded by the air bags, the lower limbs are lifted to promote venous return, the abdomen is attached to reduce suspension compression, and the comfort degree of the pregnant woman during turning over is improved.

The invention relates to a placenta tissue collecting bag and application. The placenta tissue collecting bag comprises a protective layer, a one-way exhaust valve, a first sealing strip, a second sealing strip, an antioxidant bag and a contact layer. The collection bag is of a double-layer structure, the leakage risk can be remarkably reduced, biological safety protection is improved, the antioxidant sealing bag and the one-way exhaust valve are additionally arranged, the air content in the collection bag can be greatly reduced, and therefore the oxidation rate of placenta tissue is reduced, and cell activity is kept.

The invention relates to a placenta umbilical cord insertion opening standard section automatic measurement method based on a multi-task model, and the method comprises the steps: inputting a placenta image into a YOLO multi-task model, and carrying out the recognition of a detection frame and corresponding confidence of each target structure in a placenta umbilical cord insertion opening section, and a placenta mask of the placenta umbilical cord insertion opening section; analyzing according to the detection frame of the target structure and the corresponding confidence, and determining a placenta umbilical cord insertion opening standard section and a corresponding placenta mask; according to the placenta mask of the placenta umbilical cord insertion opening standard section, obtaining the central axis and the contour line of the mask and the fan-shaped region boundary of the original image; analysis and measurement are carried out based on the central axis and the contour line of the mask and the sector region boundary of the original image to obtain an optimal placenta measurement line, and efficient and accurate placenta umbilical cord insertion opening standard tangent plane automatic measurement can be realized.

The inventions relates to Immunoglobulin A (IgA) or a pharmaceutical composition comprising IgA for use in the treatment of an infectious disease of or in an immune privileged organ, such as the eye, fetus, placenta, central nervous system (CNS) and / or testicles caused by a bacterial, fungal, viral or parasitic infection, in particular caused by bacteria of the human microbiome. IgA-coated pathogens can be addressed by FCAR+ and / or CD11c+ innate immune cells, for example by phagocytosis, or by activation of the complement system. The use of IgA or a pharmaceutical composition comprising IgA in immune privileged sites is advantageous because in contrast to IgG, IgA-coated pathogens do not trigger activation of C1q, a protein used for the controlled pruning of synapses. This prevents neuronal damage in said immune privileged organ(s), while at the same time allowing an antibody-mediated immune response in said organs.

The present invention relates to a microfluidic device configured to study epithelial and / or endothelial barrier function in a human 3D cell microtissue model, while simultaneously allowing for the application of mechanical stimuli such as luminal flow and / or lateral flow. Embodiments include three cultures representing the maternal-fetal interface (placental barrier): human umbilical vein endothelial cells (HUVEC), human placental fibroblasts (HPF), and human placental pericytes (HPP), as well as a ductal interface composed of human primary mammary gland-derived endothelial cells, fibroblasts, and epithelial layer (MCF10). The model is expandable to include tumors (cell line-derived or patient-derived). The present invention further relates to a method for fabricating a human 3D vascular microtissue model using a microfluidic device according to the present invention, and to the use of a human 3D vascular microtissue model for, for example, studying the effects of cell barrier function (solute permeability), interstitial flow, luminal flow and / or lateral flow, and epithelial and / or endothelial barrier function (solute permeability), and extravascular matrix properties (diffusivity, stiffness, transport of molecules, antibodies and / or cells, and matrix proteins). The present invention further relates to a method for presenting a pre-eclampsia (disease) model of the placental barrier, and means for testing drug therapies.

This invention relates to the fields of computer vision and medical imaging, specifically to an artificial intelligence-based method and system for detecting placental lesions. The method includes the following steps: multimodal data acquisition and fusion; acquiring multimodal data of placental lesions using imaging technology; aligning the multimodal data and labeling the lesions on visible light images to obtain baseline labels; and migrating the baseline labels to other modalities based on cross-modal spatial mapping relationships to support multimodal collaborative training. The system's software module receives encrypted raw data from the hardware module and uses containerization technology to encapsulate the model and its operating environment into independent units for deployment and operation, realizing the detection method and integrating it with external medical information systems. This invention significantly improves the detection rate of lesions and reduces the false detection rate, resulting in a significant improvement in detection performance and greatly reducing the deployment cost of hospital detection environments.

FIELD: oncology.SUBSTANCE: used to treat malignant embryonic tumors. The method involves pharmacological inhibition of factors that support tumor growth. A progesterone receptor antagonist is administered and immunological activation of the body's response against progesterone-induced blocking factor (PIBF), placental growth factor (PIGF) and trophoblastic β 1-glycoprotein.EFFECT: increased treatment reliability due to a comprehensive and selective effect on the tumor, simultaneous influence on both the primary tumor site and metastases, a reduction in the likelihood of relapse due to the destruction of the tumor vascular network, and a reduction in the overall toxic load on the patient's body during treatment.7 cl, 1 tbl, 5 ex

This invention is directed in one main aspect to a cell composition comprising a population of engineered mucosal-associated invariant T (MAIT) cells derived from placental tissue expressing an exogenous chimeric antigen receptor (CAR). The invention further discloses a unique placental MAIT cell population, cell compositions comprising the MAIT cell population, and methods of use.

1. Name of the product in this design: Packaging straps (placental pieces). 2. Purpose of this design: This product is used for bundling medicine packaging boxes. 3. The key design features of this product are its pattern and the combination of pattern and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color. 6. This design is for a thin product, therefore the left view, right view, top view, and bottom view are omitted.

To provide an improved porcine scaffold comprising decellularized porcine placental extracellular matrix. Further provided are methods of preparing the improved decellularized porcine placental extracellular matrix as well as methods of treatment.SOLUTION: Provided are porcine scaffolds comprising a decellularized porcine placental extracellular matrix, wherein the porcine scaffold comprises at least about 0.5% w / w hyaluronic acid based on the total weight of the porcine scaffold, and methods of preparing the porcine scaffolds.SELECTED DRAWING: Figure 9

Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

The present invention relates to a biomarker for diagnosing neuromyelitis optica and its use. Specifically, the present invention relates to a biomarker composition for diagnosing neuromyelitis optica comprising one or more genes selected from the group consisting of Plac8 (placenta-specific 8), Klra2 (killer cell lectin-like receptor, subfamily A, member 2) and Mcoln2 (mucolipin 2) or a protein expressed from said genes; a composition for diagnosing neuromyelitis optica comprising a substance for measuring the mRNA level of said genes or the protein level thereof; a diagnostic kit for neuromyelitis optica comprising said composition; and a method for providing information for predicting and diagnosing neuromyelitis optica.

This invention provides a method for performing a placental assessment. The method includes obtaining a 3D ultrasound image of the uterus (210) and segmenting the placenta (220). A 3D map (200) of the uterus is then generated, wherein the generation includes: identifying the location of the placenta within the uterus relative to anatomical structures such as the cervix (250); obtaining anatomical reference data regarding potential risks associated with the location of the placenta within the uterus; and comparing the location of the placenta with the anatomical reference data. Generating the 3D map of the uterus includes a 3D map of the placenta marked with indicators that change based on the comparison of the placenta's location with the anatomical reference data. The appearance of the indicators can be changed according to, for example, risk type / severity.

1. Name of the product in this design: Label (Placenta Piece). 2. Purpose of this design: This product is used to wrap medicine packaging bottles. 3. The key design features of this product are its pattern and the combination of pattern and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color. 6. This design is a two-dimensional product, so the left view, right view, top view, and bottom view are omitted; since there is no design content on the back of this product, the rear view is omitted.

A dehydrated, partially perforated, placental tissue allograft that can be used in the treatment of wounds. Specifically, the dehydrated, partially perforated placental allograft has the property of being able to be cleaned during processing without disrupting the grafts structural integrity or decreasing the concentration of growth factors found within the finished graft. The dehydrated, partially perforated, placental tissue allograft is reconstituted prior to applying it to the subject and is substantially free of undesirable maternal blood contaminants.

1. Name of the product in this design: Packaging straps (placental pieces). 2. Purpose of this design: This product is used for bundling medicine packaging boxes. 3. The key design features of this product are its pattern and the combination of pattern and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color. 6. This design is for a thin product, therefore the left view, right view, top view, and bottom view are omitted.

The invention relates to the technical field of amniotic fluid puncture examination, and particularly discloses a semi-automatic negative-pressure amniotic fluid puncture device which comprises a B-ultrasonic probe and a puncture assembly, and a locking assembly is arranged on the B-ultrasonic probe; the locking assembly comprises a transverse plate, a bottom plate is fixedly connected to the bottom of the transverse plate, a limiting seat is fixedly connected to the top of the bottom plate, a through hole is formed in the limiting seat, and locking rotary knobs are symmetrically installed on the two sides of the through hole; through the design of the locking assembly and the puncture assembly, during amniotic fluid puncture inspection, after a puncture point is detected and determined by means of a B-mode ultrasound probe, a through hole in the top of a bottom plate limiting seat is accurately aligned with the puncture point by moving the B-mode ultrasound probe, clear and fixed path guidance is provided for puncture operation, and the positioning mode is combined with a subsequent locking mechanism, so that the puncture accuracy is improved. Position deviation caused by external factors in the puncture process can be effectively avoided, it is ensured that the puncture needle accurately reaches the target position, and the risk of mistakenly puncturing a fetus or an umbilical cord or a placenta is greatly reduced.

The invention is directed to a composition of soluble placental ECM in storage solution and the methods of manufacture related thereto. The solubilized placental ECM solution is manufactured through a process of partitioning placental ECM from the placental tissue in a high acidic pH environment and performing an ultrafiltration step and diafiltration step through a tangential flow filtration system to increase the pH. The soluble placental ECM retains the native characteristics of placental ECM components and includes collagens (types I, III, V, VI, IX, and X), elastin, laminin, and fibronectin.

This invention is directed in one main aspect to a cell composition comprising a population of engineered mucosal-associated invariant T (MAIT) cells derived from placental tissue expressing an exogenous chimeric antigen receptor (CAR). The invention further discloses a unique placental MAIT cell population, cell compositions comprising the MAIT cell population, and methods of use.

The present invention provides a birth tissue derived implant for treating a subject. The birth tissue derived implant comprises a birth tissue and an agent exogenous to the birth tissue. The birth tissue is isolated from an amniotic sac, an umbilical cord or a placental plate. A method is also provided for repairing a defective tissue in a subject. The repair method comprises delivering the birth tissue derived implant to a surface of the defective tissue in the subject. The defective tissue may be an ocular membrane, a synovium, tendon, ligament, nerve, a cartilage or a bone. A method is further provided for preparing the birth tissue derived implant. The preparation method may comprise devitalizing or decellularizing a birth tissue from an amniotic sac, an umbilical cord or a placental plate, and adding an agent to the devitalized or decellularized birth tissue.

The invention relates to the technical field of biological medicine, in particular to an autophagosome for promoting hair growth and an extraction method and application thereof. Comprising the following steps: inoculating human umbilical vein endothelial cells or human placenta mesenchymal cells into a DMEM (Dulbecco Modified Eagle Medium) complete medium, and culturing until the cell fusion degree reaches 80-90%; replacing the DMEM complete culture medium with a serum-free DMEM culture medium, collecting supernate after culture is completed, and centrifuging the supernate to obtain a crude extract containing the autophagosome; and resuspending the crude extract by using PBS, adding an LC3 antibody, and finely extracting by using a paramagnetic particle method to obtain the autophagosome. The method has the advantages of simple operation process, no need of other inducers in the process of inducing the formation of the autophagosome, no too high requirements on laboratories, and high yield of the autophagosome, and provides an efficient, convenient, economical and practical treatment means for alopecia patients.

The invention relates to the technical field of stem cells, in particular to a preparation method of human placenta amnion pluripotent stem cells. The method specifically comprises the following steps: S1, tissue pretreatment and physical pre-layering; s2, carrying out mechanical-enzymatic synergistic dynamic dissociation; s3, gradient purification and washing; s4, performing soft matrix phenotype maintenance culture; according to the method disclosed by the invention, the separation efficiency of amniotic epithelial cells is improved and the enzyme exposure load is reduced through synergistic enzymolysis of Dispase II and Trypsin in combination with weak shearing force generated by the magnetic beads. Meanwhile, SB431542 blocks a signal channel to prevent EMT, a GelMA soft matrix maintains cell phenotypes, and Percoll density gradient centrifugation is matched to improve cell purity.

A sterile micronized composition prepared from intact human placental tissue that is configured for wound healing. The sterile micronized composition includes micronized human amnion; micronized human chorion; and micronized human intermediate spongy layer. In certain aspects, the composition is prepared from intact placental tissue comprising a human amnion layer, human chorion layer, and an intact human intermediate spongy layer positioned between the human amnion layer and human chorion layer such that immediately before micronization the human amnion layer and the human chorion layer are not separated from one another.